Accès ouvert
2026
article
OpenAlex
Yingying Wu, Kotaro Hiraoka, Berihu Mesfin, Asuka Kikuchi et autres
Abstract Purpose Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer’s disease (AD) brain tissue; however, their spatiotemporal dynamics in vivo remain poorly understood. This multicenter study aimed to investigate the progression of astrocyte reactivity across the AD continuum, including healthy …
jp
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Accès ouvert
2026
article
OpenAlex
Masanori Kurihara, Ryoko Ihara, Gen Yoshii, Ryosuke Shimasaki et autres
BACKGROUND: While amyloid-β (Aβ) biomarker positivity is sufficient before initiating anti-Aβ antibody therapy, recent revised criteria also highlight the importance of other biomarkers (ATNIVS) to understand heterogeneity in AD. DESIGN, SETTING, AND PARTICIPANTS: F-MK6240). MRI was assessed using Fazekas score. Remaining samples …
jp, fr
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Accès ouvert
2026
article
OpenAlex
Kai Funakawa, Masanori Kurihara, Kensuke Takahashi, Ryoko Ihara et autres
The patient was a 36-year-old woman with normal birth and development. The patient experienced gradual memory loss from the age of 29 years old. The patient showed irritability at 35, convulsion at 36, and was diagnosed to have early-onset dementia. Family history …
jp
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Accès ouvert
2025
preprint
OpenAlex
Masanori Kurihara, Ryoko Ihara, Gen Yoshii, Ryosuke Shimasaki et autres
Abstract Background While amyloid-β (Aβ) biomarker positivity is sufficient before initiating anti-Aβ antibody therapy, recent revised criteria also highlight the importance of other biomarkers (ATNIVS) to understand heterogeneity in AD. Design, Setting, and Participants We reviewed patients who attended our specialty clinic …
jp, fr
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Accès ouvert
2025
article
OpenAlex
Masanori Kurihara, Nicholas Ashton, Przemyslaw Radoslaw Kac, Giovanni De Santis et autres
BACKGROUND: Now that plasma tau assays show excellent diagnostic accuracy for AD, clinical implementation is important. Although renal function is known to affect values in some assays, it was unknown whether the effect size differs between assays in reference to CSF values. …
jp, se
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Accès ouvert
2025
article
OpenAlex
Masaki Ikeda, Kenji Ishibashi, Masakuni Amari, Masaru Matsumura et autres
We report neuroimaging findings from a 74-year-old right-handed male with Alzheimer’s disease (AD) and lesions of cerebral amyloid angiopathy (CAA), utilizing 11 C-PiB-PET, 18 F-THK5351-PET, and 18 F-MK-6240-PET. 11 C-PiB-PET showed positive findings consistent with AD. 18 F-THK5351 accumulated in regions of …
jp
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Accès ouvert
2025
article
OpenAlex
Kenji Ishibashi, Masanori Kurihara, Ryoko Ihara
To the Editor: We have recently highlighted the potential pitfalls of amyloid-beta (Aβ) PET, suggesting that both Aβ and tau assessments are necessary to relate clinical symptoms to Alzheimer disease (AD) pathology.1 Herein, we would like to present 3 additional cases related …
jp
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Accès ouvert
2025
article
OpenAlex
Ryosuke Shimasaki, Masanori Kurihara, Kenji Ishibashi, Aya M. Tokumaru et autres
Diagnosing frontal variant Alzheimer's disease (fvAD) is difficult and could be even more difficult when amyloid-beta (Aβ) PET retention is low. A 63-year-old woman presenting with a 3-year history of apathy and memory impairment showed executive dysfunction, memory impairment, and severe bilateral …
jp
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Accès ouvert
2025
article
OpenAlex
Risa Kotani, Keiko Hatano, Kenji Ishibashi, Atsushi Iwata
This manuscript complements the clinical course of the first case of neurosyphilis in our previous report (Kotani. et al. Clin Nuc Med 2024) which highlighted the utility of 18F-THK5351 positron emission tomography (PET), a marker of astrogliosis, to visualize neuroinflammation. The patient …
jp
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Accès ouvert
2024
article
OpenAlex
Yuta Komori, Masanori Kurihara, Ryoji Goto, Maki Obata et autres
Objective: Previous studies of topographical disorientation have focused on cerebrovascular diseases. However, a detailed assessment of patients with neurodegenerative diseases may aid our understanding of spatial navigation. We report the case of a patient with right temporal variant frontotemporal dementia (rtvFTD) initially …
jp
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Accès ouvert
2024
article
OpenAlex
Masashi Kameyama, Muneyuki Sakata, Kenji Ishibashi, Tetsuro Tago et autres
Abstract Background The method of obtaining pseudo‐cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites …
jp
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Accès ouvert
2024
article
OpenAlex
Masashi Kameyama, Muneyuki Sakata, Kenji Ishibashi, Tetsuro Tago et autres
Abstract Background The method of obtaining pseudo‐cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites …
jp
(code pays fourni par la source)