Accès ouvert
2026
article
OpenAlex
Yiran Wang, Jindayi Liang, Kimberly S. Lange, Justin Demmerle et autres
TEA domain transcription factor 1 (TEAD1), a Hippo pathway transcription factor important in cellular homeostasis and development, is increasingly implicated in cancer biology. Here we reveal an unexpected role for TEAD1 in organizing nuclear condensates, independent of active transcription. Using high-resolution imaging, …
us
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Accès ouvert
2026
preprint
OpenAlex
Samuel Botterbusch, Vienna Huso, Kyler A. Weingartner, Grétar Tryggvason et autres
Abstract Trans-autophosphorylation is the most common mode of protein kinase activation and involves two copies of the same kinase dimerizing so that one can phosphorylate the activation loop of the other. The diversity among structures of trans -autophosphorylation dimers supported the view …
us, bg, ru
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Jonathan C. Vose, Elizabeth I. Harper, Sheetal Kooduvalli, Joanne T. Kotelawala et autres
Abstract Ovarian cancer is one of the leading causes of cancer related deaths for women. First-line treatment includes surgical resection followed by a regimen of cisplatin. More than 70% of tumors, however, acquire chemoresistance. Our understanding of the molecular mechanisms mediating this …
us
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Yiran Wang, Jindayi Liang, Kimberly Lange, Justin Demmerle et autres
This dataset contain image data of microscopic experiments reported in the paper titled “TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells”. Abstract: TEA domain transcription factor 1 (TEAD1), a Hippo pathway transcription factor important in cellular …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Dezmond Cole, Andrew S. Eneim, Cory J. White, Chelsy R. Eddings et autres
Problem: All trainees, especially those from historically minoritized backgrounds, experience stresses that may reduce their continuation in science, technology, engineering, math, and medicine (STEMM) careers. The Johns Hopkins University School of Medicine is one of ~45 institutions with a National Institutes of …
gb, pl, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kyler A. Weingartner, T. Thao Tran, Katherine W. Tripp, Jennifer M. Kavran
The Hippo pathway controls tissue growth and regulates stem cell fate through the activities of core kinase cassette that begins with the Sterile 20-like kinase MST1/2. Activation of MST1/2 relies on trans-autophosphorylation but the details of the mechanisms regulating that reaction are …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Nelson V Guevara, Zirui Zhu, Esha Jain, Jennifer M. Kavran et autres
Abstract The estrogen receptor-positive (ER+) subtype accounts for 70% of breast cancer, and endocrine therapies that target ER are effective in the early-stage clinical setting. However, endocrine resistance is ubiquitous in late-stage metastatic breast cancer (MBC). The chief mechanism is the acquisition …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Tao-Hsin Chang, Fu-Lien Hsieh, Xiaowu Gu, Philip M. Smallwood et autres
In many organs, small openings across capillary endothelial cells (ECs) allow the diffusion of low-molecular weight compounds and small proteins between the blood and tissue spaces. These openings contain a diaphragm composed of radially arranged fibers, and current evidence suggests that a …
us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Kyler A. Weingartner, T. Thao Tran, Katherine W. Tripp, Jennifer M. Kavran
ABSTRACT The Hippo pathway controls tissue growth and regulates stem cell fate through the activities of core kinase cassette that begins with the Sterile 20-like kinase MST1/2. Activation of MST1/2 relies on trans -autophosphorylation but the details of the mechanisms regulating that …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Teresa Bonello, Danfeng Cai, Georgina Fletcher, Kyler Wiengartner et autres
The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the Warts kinase (Wts; LATS1/2 in mammals). The Hpo kinase is activated by …
au, us, gb
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Thomas J. Koehler, T. Thao Tran, Kyler A. Weingartner, Jennifer M. Kavran
Canonically, MST1/2 functions as a core kinase of the Hippo pathway and noncanonically during both apoptotic signaling and with RASSFs in T-cells. Faithful signal transduction by MST1/2 relies on both appropriate activation and regulated substrate phosphorylation by the activated kinase. Considerable progress …
us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Thomas J. Koehler, T. Thao Tran, Jennifer M. Kavran
ABSTRACT Canonically, MST1/2 functions as a core kinase of the Hippo pathway and non-canonically is both activated during apoptotic signaling and acts in concert with RASSFs in T-cells. Faithful signal transduction relies on both appropriate activation and regulated substrate phosphorylation by the …
us
(code pays fourni par la source)