Zirui Zhu

Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial

Amanda L. Huff, S. Daniel Haldar, Alexander A. Gergis, Hejia Henry Wang et autres

In this phase I study, we test a pooled synthetic long peptide vaccine targeting the six KRAS mutations (G12V, G12A, G12R, G12C, G12D, G13D) with ipilimumab and nivolumab in resected pancreatic adenocarcinoma. Co-primary endpoints include safety and maximal percent change of IFNγ-producing …

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Mechanistic Insights into Wettability Evolution in Palm Leaf Manuscripts: From Natural Architecture to Aged Surfaces

Zirui Zhu, Yanxiao Hu, Shuang Yu, Haohai Yu et autres

Wettability, a fundamental issue in surface science, plays a pivotal role in the degradation behavior and conservation effectiveness of cultural heritages, especially for organic ones. In this research, we present a comprehensive investigation into the wettability evolution of palm leaf manuscripts, a …

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Performance evaluation and application of nano-metakaolin modified natural hydraulic lime for stone cultural heritage restoration

Yanlong Ji, Zirui Zhu, Haitao Yan, Jinhua Wang et autres

Stone cultural heritage suffers from significant degradation due to long-term environmental exposure, necessitating repair materials that exhibit high workability, compatibility, and durability. In this study, a natural hydraulic lime (NHL5)-based composite mortar modified with nano-metakaolin (NMK) was developed. The workability, compatibility, and …

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SAT-396 Scenario Changing and Efficacy of Therapeutic Plasma Exchange in the Treatment of Thyrotoxicosis

Zirui Zhu, Xinran Gao, Ge Bai, Honghua Wu et autres

Abstract Disclosure: Z. Zhu: None. X. Gao: None. G. Bai: None. H. Wu: None. Y. Huang: None. J. Zhang: None. Y. Gao: None. Y. Zhang: None. Background: Current guidelines primarily recommend TPE for thyroid storm, with limited recommendations for other indications of …

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Lattice‐Matched S‐Scheme High‐Entropy Oxide Heterojunction for Efficient Visible‐Light‐Driven CO 2 Photomethanation

Xian Shi, Weidong Dai, Xiaoqian Li, Zirui Zhu et autres

Abstract Constructing S‐scheme heterojunctions provides an efficient approach for promoting spatial separation of photogenerated charge carriers, making it highly advantageous for photocatalytic applications. However, the limited interfacial contact between adjacent phases in S‐scheme heterostructures can hinder efficient charge transport, thereby reducing overall …

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Acute degradation of nucleolin reveals its novel functions in cell cycle progression and cell division in triple negative breast cancer

Joseph Mills, Anna Tessari, Vollter Anastas, Damu Sunilkumar et autres

INTRODUCTION: Nucleoli are large nuclear sub-compartments where vital processes, such as ribosome assembly, take place. Most nucleolar proteins are essential; thus, their abrogation cannot be achieved through conventional approaches. This technical obstacle has limited our understanding of the biological functions of nucleolar …

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Microscopic characteristics and weathering mechanism of pigment layers in Huashan Rock Art, Guangxi, China

Yi Wang, Zirui Zhu, Biao Cui, Jinhua Wang et autres

Huashan Rock Art, located in Guangxi, China, reflects the social, economic, cultural, and artistic aspects of the local ancestors and is included in the World Cultural Heritage list. However, surface cracking and pigment layer detachment have severely affected its value. This study …

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Tag-like cyclic peptides: Modular affinity elements for protein integration and bioengineering applications

Zirui Zhu, Andrew Poweleit, Wenjun Sun, Haowei Ma et autres

Cyclic peptides have emerged as highly versatile compounds in drug development and bioengineering, offering unique structural stability, binding specificity, and reduced susceptibility to proteolysis compared to their linear counterparts. These properties make cyclic peptides valuable in a range of therapeutic applications, from …

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Spermidine attenuates microglial activation, neuroinflammation, and neuronal injury in rat model of vascular dementia

Xinyuan Zhao, Dan Li, Zirui Zhu, Suzhen Li et autres

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Deciphering Metabolic Responses in Traumatic Brain Injury Patients With Different Severity Using 1 H NMR‐Based Serum Metabolomics

Huan‐Xiang Zhou, Dongdong Sun, Dongmei Wang, Zirui Zhu et autres

The analysis of metabolites presents a promising opportunity to gain insight into the neuropathophysiology of individuals affected by traumatic brain injury (TBI). In order to elucidate the underlying pathophysiologic mechanisms and identify serum biomarkers associated with TBI, we conducted a comprehensive investigation …

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Antibody numbering schemes: advances, comparisons and tools for antibody engineering

Zirui Zhu, Hossein Ashrafian, Navid Mohammadian Tabrizi, Emily R Matas et autres

The evolution of antibody engineering has significantly enhanced the development of antibody-based therapeutics, enabling the creation of novel antibody formats tailored for specific applications. Since the introduction of the Kabat numbering scheme in 1977, various schemes have been developed and modified, forming …

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A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72

Reham Hassan, Zirui Zhu, Mingyang Ji, Ziyuan Meng et autres

A camptothecin (CPT)-dilysine nanotube, stabilized with a layer of polydopamine (PDA), was functionalized on the surface with anti-TAG-72 antibody fragments. Cell viability studies showed that the presence of the targeting anti-TAG-72 scFv significantly enhanced cytotoxicity against TAG-72 positive, LS-174T colon cancer cells, …

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