Takahiro Matsuno

Respiratory Pathogen Detection in Pediatric Asthma Exacerbations Using the FilmArray Respiratory Panel 2.1

Masato Itano, Yoshiki Kawamura, Takahiro Matsuno, Natsuki Hatakawa et autres

Viral infections, particularly rhinoviruses (RVs) and respiratory syncytial virus (RSV), are major causes of pediatric acute asthma exacerbations. The FilmArray Respiratory Panel 2.1 (FARP2.1) is an automated multiplex PCR tool that is being increasingly used in clinical settings; however, its application in …

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Interstitial palladin is associated with tubulointerstitial chronicity and adverse outcomes in patients with lupus nephritis

Naoki Yamamoto, Norihiko Sakai, Shiori Nakagawa, Daichi Kaikoi et autres

Background Tubulointerstitial lesions predict kidney prognosis in lupus nephritis (LN), but the molecular features of interstitial fibrosis remain incompletely defined. We previously showed that palladin, an actin-associated protein, drives kidney fibrosis through actin dynamics. This study examined whether interstitial palladin expression is …

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Interstitial palladin expression is associated with increased risk of end-stage kidney disease and death in patients with biopsy-proven diabetic kidney disease

Naoki Yamamoto, Norihiko Sakai, Daichi Kaikoi, Takahiro Matsuno et autres

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The diagnostic value of uromodulin protein measurement in autosomal dominant tubulointerstitial kidney disease due to uromodulin mutation (ADTKD-UMOD): serum or urine?

Tamehito Onoe, Mitsuhiro Kawano, I. Mizushima, Kiyoaki Ito et autres

BACKGROUND: Autosomal dominant tubulointerstitial kidney disease caused by uromodulin mutation (ADTKD-UMOD) is a hereditary condition characterized by progressive renal dysfunction, often requiring renal replacement therapy by middle age. A notable feature is a strong family history of chronic kidney disease (CKD) and …

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Probing simulator capable of independently measuring probing force and resting force

Takahiro Matsuno, Atsushi Mitani, Shinichi Hirai

In periodontal examinations, precise probing force and effective stabilization of the probe are critical skills for practitioners. The ability to insert the probe with an appropriate force highlights the importance of comprehensive skill training. To address this need, we designed and developed …

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Fibroblast‐specific palladin drives kidney fibrosis via MRTF – SRF signaling

Naoki Yamamoto, Norihiko Sakai, Yuta Yamamura, Daichi Kaikoi et autres

Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts. However, it has not been …

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CD45 + C1q + CCR8 + Cells as Emerging Indicators of Kidney Disease Severity and Progression Risk

Koichi Sato, Megumi Oshima, Norihiko Sakai, Yu Oshima et autres

AIM: Fibrosis is a common mechanism underlying the progression of kidney and other organ failures. Complement protein C1q and chemokine receptor 8 (CCR8), whose ligand is CCL1, are implicated in fibrosis. This study aimed to evaluate the clinical significance of CD45+ mononuclear …

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Limitations of MALDI-TOF MS in identifying anaerobic bacteremia: challenges in polymicrobial infections and the role of whole-genome sequencing

Takuya Hosoda, Masahiro Suzuki, Takahiro Matsuno, Koji Ohyama et autres

With the widespread use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), the number of identifiable bacterial species has increased. However, anaerobic bacteremia remains challenging to accurately diagnose due to the diverse range of anaerobic bacteria and the frequent occurrence …

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A Snap Mechanism Imitating the Thoracic Joint of a Click Beetle

Takahiro Matsuno, Ryuma Niiyama, Shinichi Hirai

In this study, we focused on the thoracic joint of a click beetle and proposed a two-link type snap mechanism. This mechanism mimics the click beetle's principle for storing and releasing elastic energy, and is composed of links, springs, motors, viscoelastic peg, …

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Development of a Passive Switching Actuator-less Robot Gripper for Grasping and Releasing

Mizuki Okita, Takahiro Matsuno

In this study, we proposed a robot gripper that utilizes bidirectional stability to achieve approach motions and object grasping without the need for actuators. When the gripper extends toward the target object, it passively transitions to a grasping motion after making contact …

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Food samples with built-in sensors for evaluating robot grippers that can estimate the success or failure of pick-and-place

Takahiro Matsuno, Shinichi Hirai

This study proposed food samples built-in sensors for evaluating gripper in food-handling applications. By embedding sensors into food sample, the application can estimate the success or failure of pick-and -place. The process involved scanning the 3D shapes of food items (e.g. daifuku …

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1-3 先端ロボット工学研究センター活動報告

健 黄, 淳也 樹野, 敦 白井, 瑞穂 柴田 et autres

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