Takuya Hosoda

Clinical and Molecular Characteristics of Streptococcus dysgalactiae subsp. equisimilis Bacteremia in Japan

Takahiro Matsuno, Masahiro Suzuki, Takuya Hosoda, Yohei Doi

Abstract Background Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of invasive infection, particularly in aging populations. We investigated the clinical and genomic characteristics of SDSE bacteremia at a Japanese medical center serving a large older-adult population. Methods We retrospectively analyzed …

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Phenotypic screening of hypervirulent Klebsiella pneumoniae using tellurite resistance and carbohydrate fermentation testing

Koji Ohyama, Akiko Sei, Takuya Hosoda, Sohei Harada et autres

ABSTRACT Phenotypic identification of hypervirulent Klebsiella pneumoniae in routine laboratories remains challenging. We evaluated tellurite resistance and selected carbohydrate fermentation tests as phenotypic tools for screening hypervirulent strains and improving lineage identification. A total of 193 K. pneumoniae species complex strains with …

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Difficult-to-treat resistance (DTR), treatment, and outcomes of carbapenem-resistant Enterobacterales infections in the setting of IMP-type carbapenemase predominance in Japan

Koji Ohyama, Kohei Uemura, Yasufumi Matsumura, Ryota Hase et autres

ABSTRACT Carbapenem-resistant Enterobacterales (CRE) pose a global threat due to limited treatment options and high mortality. Difficult-to-treat resistance (DTR), defined as non-susceptibility to all conventional β-lactams and fluoroquinolones, has primarily been applied to Pseudomonas aeruginosa . However, its relevance for Enterobacterales remains …

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In vitro activity of cefiderocol against carbapenem-resistant Gram-negative pathogens in Japan

Kenjiro Matsui, Aki Sakurai, Yasufumi Matsumura, Takuya Hosoda et autres

INTRODUCTION: Carbapenem-resistant Gram-negative bacteria (CRGNB) pose a major clinical threat. This study evaluated the in vitro activity of cefiderocol and other recently approved β-lactam/β-lactamase inhibitor combinations against major CRGNB. MATERIALS AND METHODS: A total of 292 CRGNB clinical isolates were analyzed, comprising …

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Limitations of MALDI-TOF MS in identifying anaerobic bacteremia: challenges in polymicrobial infections and the role of whole-genome sequencing

Takuya Hosoda, Masahiro Suzuki, Takahiro Matsuno, Koji Ohyama et autres

With the widespread use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), the number of identifiable bacterial species has increased. However, anaerobic bacteremia remains challenging to accurately diagnose due to the diverse range of anaerobic bacteria and the frequent occurrence …

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Transmission of NDM-5-Producing and OXA-48-Producing Escherichia coli Sequence Type 648 by International Visitors without Previous Medical Exposure

Sohei Harada, Masahiro Suzuki, Toshiharu Sasaki, Aki Sakurai et autres

(CPE) is endemic but have no history of local hospitalization contribute to the transmission of CPE. In this study, NDM-5-producing and OXA-48-producing Escherichia coli sequence type (ST) 648, a recently recognized high-risk, multidrug-resistant clone, were detected from two overseas visitors without previous …

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Emergence of Salmonella Strain That Produces IMP-1-Type Metallo-^|^beta;-Lactamase in a Japanese Patient

Takuya Hosoda, Mitsutaka Wakuda, Junnichi Ishii, Ikuya Tsuge et autres

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