Yukiko Muramoto

Anticipated regret suppresses option collection: a breadth–depth framework for pre-decisional search

Rio Sumida, Yukiko Muramoto

Although anticipated regret is known to regulate choice from a given set of options, its role in actively collecting those options remains largely unknown. This study proposed and tested a framework distinguishing regret over insufficient breadth (accelerator) from regret over insufficient depth …

Anticipated regret suppresses option collection: a breadth–depth framework for pre-decisional search

Rio Sumida, Yukiko Muramoto

Although anticipated regret is known to regulate choice from a given set of options, its role in actively collecting those options remains largely unknown. This study proposed and tested a framework distinguishing regret over insufficient breadth (accelerator) from regret over insufficient depth …

jp (code pays fourni par la source)

Anticipated regret suppresses option collection: a breadth–depth framework for pre-decisional search

Rio Sumida, Yukiko Muramoto

Although anticipated regret is known to regulate choice from a given set of options, its role in actively collecting those options remains largely unknown. This study proposed and tested a framework distinguishing regret over insufficient breadth (accelerator) from regret over insufficient depth …

Two functions of anticipated regret in active option search: An accelerator to ensure the quantity of options and a brake to improve their quality

Rio Sumida, Yukiko Muramoto

Runtime-steered ultrashort molecular dynamics enables million-pose protein–ligand screening

Natsuki Kanazawa, Junta Asano, Mitsugu Araki, Shingo Okuno et autres

Applying molecular dynamics (MD) at discovery scale is limited by the cost of evaluating thousands to millions of candidate poses. We present a docking-to-dynamics workflow that makes MD compatible with screening-scale evaluation by applying ensembles of ultrashort trajectories (0.1–5 ns) to each …

jp, us, es (code pays fourni par la source)

Multimerization of secretory IgA enhances antiviral activity by aggregating influenza A virus particles

Koji Yamauchi, Yukiko Muramoto, Yoko Fujita, Ai Hirabayashi et autres

Secretory immunoglobulin A (sIgA), the first line of defense against mucosal epithelial infections, is a multimer. Although multimeric sIgA shows higher antiviral activity than monomeric IgA, the mechanism underlying this enhancement and the functional differences among IgA subclasses remain unclear. Here, we …

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Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia

Keiko Yasuda, Junichi Aoki, Kotaro Tanaka, Shintaro Shichinohe et autres

The innate immune response to viral infection needs to be tightly regulated to ensure effective pathogen clearance while avoiding excessive immune activation. During SARS-CoV-2 infection, however, the immune system often fails to elicit appropriate responses, resulting in cytokine-release syndrome in patients with …

jp (code pays fourni par la source)

Clarifying the ideal point: Can it reduce regret?

Rio Sumida, Yukiko Muramoto

Although a considerable number of options increases the likelihood of encountering an ideal choice, it also imposes excessive cognitive load, making it difficult to compare options thoroughly and thereby leading to stronger regret and lower satisfaction. This phenomenon, known as the choice …

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Influenza A virus circumvents the innate immune response through the sequestration of double-stranded RNA

Masahiro Nakano, Shô Miyamoto, Chiho Ohnishi, Chiharu Nogami et autres

ABSTRACT Double-stranded RNA (dsRNA), which induces an innate immune response against viral infections, is rarely detected in influenza A virus (IAV)-infected cells. Nevertheless, we previously reported that the influenza A viral ribonucleoprotein (vRNP) complex generates looped dsRNAs during RNA synthesis in vitro …

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Isogenic induced-pluripotent-stem-cell-derived airway- and alveolus-on-chip models reveal specific innate immune responses

Sachin Yadav, Kazuya Fujimoto, Toru Takenaga, Senye Takahashi et autres

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Reputation promotes COVID ‐19 infection prevention behaviours especially among unvaccinated people and those who perceived a lower risk

Shuma Iwatani, Yukiko Muramoto

Abstract The global COVID‐19 outbreak caused severe physical and economic damage. This study focused on the interpersonal factors among Japanese people and attempted to elucidate why the impact in Japan was milder than that in other countries. Previous studies have demonstrated that …

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Structural basis for Ebola virus nucleocapsid assembly and function regulated by VP24

Yoko Fujita, Shangfan Hu, Ai Hirabayashi, Yuki Takamatsu et autres

The Ebola virus, a member of the Filoviridae family, causes severe hemorrhagic fever in humans. Filamentous virions contain a helical nucleocapsid responsible for genome transcription, replication, and packaging into progeny virions. The nucleocapsid consists of a helical nucleoprotein (NP)–viral genomic RNA complex …

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