Rutger Jan Röring

Systemic Inflammation and Molar Incisor Hypomineralisation: A Cohort Study

S. Shields, T. Chen, F S Crombie, David John Manton et autres

Molar incisor hypomineralisation (MIH) is a common developmental dental defect of unknown etiology and considerable morbidity. Observational and experimental studies suggest systemic inflammation as a key mechanism, but there are no prospective human data. This study aimed to describe how the prevalence …

au, nl (code pays fourni par la source)

QTL statistics for all stimuli

Rutger Jan Röring

QTL results for all stimuli, for all analytes that were well-detectable (>50% of samples within detectable range). Not truncated, but only autosomal variants >5% MAF as described in methods.

au (code pays fourni par la source)

Code used for analysis/figures in manuscript

Rutger Jan Röring

Code used for performing analyses and creating figures in this manuscript. Most data cannot be made available due to ethics agreement of BIS.

au (code pays fourni par la source)

QTL statistics for all stimuli

Rutger Jan Röring

QTL results for all stimuli, for all analytes that were well-detectable (>50% of samples within detectable range). Not truncated, but only autosomal variants >5% MAF as described in methods.

au (code pays fourni par la source)

Code used for analysis/figures in manuscript

Rutger Jan Röring

Code used for performing analyses and creating figures in this manuscript. Most data cannot be made available due to ethics agreement of BIS.

au (code pays fourni par la source)

Genetic, intrinsic, and environmental determinants of innate immune cytokine responses in healthy four-year-old children

Rutger Jan Röring, Luba Sominsky, Katherine Lange, Aaron L. Weinman et autres

Abstract/Summary Innate immune responses are crucial for host defence but vary markedly between individuals. Although determinants of this variation are well characterised in adults, data from healthy children remain scarce. We therefore profiled whole-blood cytokine responses to innate immune stimulation in 286 …

au, fi, gb, se, de, nl (code pays fourni par la source)

Evaluating the non-specific effects of BCG vaccination on the immune system and serological response to influenza vaccination in the elderly: A randomised controlled trial

Anne Marie Rosendahl Madsen, Frederik Schaltz‐Buchholzer, Ramona Trebbien, Rutger Jan Röring et autres

OBJECTIVES: The Bacillus Calmette-Guerin (BCG) vaccine has beneficial effects on the immune system, which may lead to non-specific protection against non-tuberculous infections and increase the response to subsequent vaccinations. Seasonal influenza vaccination is used to protect senior citizens against influenza, but the …

dk, Guinée-Bissau, nl (code pays fourni par la source)

Interferon gamma rebalances immunopathological signatures in chronic granulomatous disease through metabolic rewiring

Mariolina Bruno, Charlotte Kröger, Anaísa V. Ferreira, Bo-Wen Zhang et autres

ABSTRACT: Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent life-threatening infections and hyperinflammatory complications. It is caused by mutations in the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and the consequent loss of reactive oxygen species (ROS) production. …

nl, de, cn, au, gb, es, ro, ch, pt (code pays fourni par la source)

Effect of Saccharomyces cerevisiae β-glucan on the T helper cytokine profile

Patricia Vuscan, Rutger Jan Röring, Brenda Kischkel, María Tintoré et autres

ABBi16 is a high-complexity blend of β-1,3/1,6-glucans from Saccharomyces cerevisiae with strong immunomodulatory activities, that have been recently shown to support anti-tumoral immune responses through the induction of trained immunity. Whether ABBi16 also modulates the balance between the various T helper (Th) …

nl, ro (code pays fourni par la source)

Evaluating the Non-Specific Effects of Bcg Vaccination on the Immune System and Serological Response to Influenza Vaccination in the Elderly: A Randomised Controlled Trial

Anne Marie Rosendahl Madsen, Frederik Schaltz‐Buchholzer, Ramona Trebbien, Rutger Jan Röring et autres

dk, Guinée-Bissau, nl, us (code pays fourni par la source)

Long‐term effects of influenza and Bacille Calmette–Guérin vaccination on systemic inflammation

Priya A. Debisarun, Rutger Jan Röring, Ozlem Pinar Bulut, Thijs ten Doesschate et autres

Objective: Chronic systemic inflammation can lead to metabolic, cardiovascular and neurodegenerative complications, but the factors influencing it are incompletely understood. In this study, we evaluated several factors, including Bacille Calmette-Guérin (BCG) and influenza vaccination, SARS-CoV-2 infection and sex, that may impact systemic …

nl, au, ro, de (code pays fourni par la source)

Interleukin-10 inhibits important components of trained immunity in human monocytes

Rutger Jan Röring, Flavia Scognamiglio, Lisanne C. de Jong, Laszlo A. Groh et autres

Trained immunity induces antigen-agnostic enhancement of host defense and protection against secondary infections, but inappropriate activation can contribute to the pathophysiology of inflammatory diseases. Tight regulation of trained immunity is therefore needed to avoid pathology, but little is known about the endogenous …

au, nl, us, ro, de (code pays fourni par la source)