Anaísa V. Ferreira

Data from: Lunar and Martian Regolith Simulants Compromise Airway Barrier Function and Trigger Inflammation

Özlem Bulut, Mario Pérez-Diego, Tommaso Zaccaria, Anaísa V. Ferreira et autres

The data and steps to reproduce described here refer to the study titled: Lunar and Martian Regolith Simulants Compromise Airway Barried Function and Trigger Inflammation. The data includes quantification of cytokines and chemokines, cytotoxicity assay, transepithelial electrical resistance measurements, Paracellular FITC-Dextran flux …

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Identification of a robust metabolic signature associated with hospital-acquired pneumonia and response to interferon-gamma treatment in critically ill patients

Mélanie Petrier, Debajyoti Sinha, Florian P. Martin, Cécile Poulain et autres

AIM: Our objective was to increase our understanding of the effects of the time course of metabolic alterations on the risk of hospital-acquired pneumonia (HAP) and response to treatment in critically ill patients. METHODS: We first studied the blood metabolome at day …

fr, nl, au, es, gb, gr, de (code pays fourni par la source)

Data from: Lunar and Martian Regolith Simulants Compromise Airway Barrier Function and Trigger Inflammation

Özlem Bulut, Mario Pérez-Diego, Tommaso Zaccaria, Anaísa V. Ferreira et autres

The data and steps to reproduce described here refer to the study titled: Lunar and Martian Regolith Simulants Compromise Airway Barried Function and Trigger Inflammation. The data includes quantification of cytokines and chemokines, cytotoxicity assay, transepithelial electrical resistance measurements, Paracellular FITC-Dextran flux …

es, de (code pays fourni par la source)

Metabolic Memory Resides in the Hematopoietic Marrow and in Arterial Resident Leukocytes

Anaísa V. Ferreira, Matthias Nahrendorf

us (code pays fourni par la source)

Bacillus Calmette–Guérin-induced trained immunity potentiates TH17 responses in vitro

Leonie S. Helder, Laszlo A. Groh, Vasiliki Matzaraki, Rob ter Horst et autres

Trained immunity amplifies innate immune responses in an antigen-independent manner. This study explored the ability of trained human primary macrophages to modulate the phenotype and function of T cells. Macrophages play an important role in antigen presentation, resulting in T-cell activation and …

nl, us, at, ro, de (code pays fourni par la source)

Effects of simulated Martian environmental stressors on specific human pathogen–immune system interactions

Tommaso Zaccaria, Ozlem Pinar Bulut, Anaísa V. Ferreira, Margo Dona et autres

ABSTRACT The identification of health risks associated with long-term crewed missions to Mars is critical for mission planning and crew safety. Human-associated pathogens can be part of the microbiome and are likely to be transported during these missions. This study examines the …

nl, us, de, jp (code pays fourni par la source)

Interferon gamma rebalances immunopathological signatures in chronic granulomatous disease through metabolic rewiring

Mariolina Bruno, Charlotte Kröger, Anaísa V. Ferreira, Bo-Wen Zhang et autres

ABSTRACT: Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent life-threatening infections and hyperinflammatory complications. It is caused by mutations in the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and the consequent loss of reactive oxygen species (ROS) production. …

nl, de, cn, au, gb, es, ro, ch, pt (code pays fourni par la source)

Arginine metabolism supports metabolic reprogramming in trained immunity

Laura M. Merlo Pich, Athanasios Ziogas, Anaísa V. Ferreira, Nicholas A. Sumpter et autres

Trained immunity, also termed innate immune memory, is supported by the metabolic rewiring of innate immune cells, altering their bioenergetic profile and ultimately their functions. While amino acids such as arginine are known to possess immunomodulatory properties, their role in trained immunity …

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Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

Athanasios Ziogas, Boris Novakovic, Lorenzo Ventriglia, Noriko Galang et autres

nl, au, it, ca, de, ro (code pays fourni par la source)

Immune responses to human pathogens exposed to simulated Mars conditions

Tommaso Zaccaria, Ozlem Pinar Bulut, Anaísa V. Ferreira, Margo Dona et autres

Abstract The identification of health risks associated with long-term crewed missions to Mars is critical for mission planning and crew safety. Human-associated pathogens can be part of the microbiome and are likely to be transported during these missions. This study examines the …

nl, de (code pays fourni par la source)

RORα negatively regulates BCG-induced trained immunity

Gizem Kılıç, Vasiliki Matzaraki, Ozlem Pinar Bulut, İlayda Baydemir et autres

Trained immunity is a long-lasting change in the responsiveness of innate immune cells, leading to a stronger response upon an unrelated secondary challenge. Epigenetic, transcriptional, and metabolic reprogramming contribute to the development of trained immunity. By investigating the impact of gene variants …

nl, ro (code pays fourni par la source)

Metabolic Regulation in the Induction of Trained Immunity

Anaísa V. Ferreira, Jorge Domínguez‐Andrés, Laura M. Merlo Pich, Leo A. B. Joosten et autres

The innate immune system exhibits features of memory, termed trained immunity, which promote faster and more robust responsiveness to heterologous challenges. Innate immune memory is sustained through epigenetic modifications, affecting gene accessibility, and promoting a tailored gene transcription for an enhanced immune …

nl, ro, de (code pays fourni par la source)