Jixian Wang

IFN ‐ γ ‐Responsive Microglia‐Derived Extracellular Vesicles Impair White Matter Repair After Stroke Through a miR ‐9‐5p/ NEDD4 ‐Dependent Mechanism

Dongliang Qian, Tongtong Xu, Yiyan Guo, Shiyu Deng et autres

Promoting white matter repair is crucial for functional recovery after ischemic stroke. Our previous study has identified an IFN-γ-responsive microglia phenotype in the brain after stroke. However, its role in white matter repair remains poorly understood. Herein, we find that extracellular vesicles …

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Load-dependent Motor Cortical Activation Assessed by fNIRS Is Partially Preserved After Stroke

Zeyu Wang, Zhi Chen, Jin Yan, Siqi Yang et autres

OBJECTIVE: The aim of this study was to investigate whether patients with stroke retain proportional hemodynamic cortical responses to increasing mechanical loading during upper limb exercise. DESIGN: Twelve patients with stroke and twelve healthy control subjects participated in this cross-sectional comparative study. …

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Dissecting the TMEM132A-EGFR Dependency to Unlock Translational Therapeutic Opportunities for Pan-Solid Tumor

Yaru Fu, Qiqi Ni, Junhao Wang, Mingyu Wu et autres

Abstract Solid tumors remain refractory to conventional treatments, yet cell surface proteins, by virtue of their extracellular accessibility and critical roles in tumor signaling, represent an attractive class of targets for precision-targeted therapy. Here, we report that transmembrane protein 132A (TMEM132A) is …

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Lisocabtagene maraleucel combined with ibrutinib in R/R CLL or SLL: primary results from TRANSCEND CLL 004

William G. Wierda, Kathleen Anne Dorritie, Jordan Gauthier, Rajneesh Nath et autres

Patients in the liso-cel plus ibrutinib cohort of the phase 1/2, open-label TRANSCEND CLL 004 study had relapsed/refractory chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and received liso-cel (50×106 [dose level (DL)1] or 100×106 [DL2] chimeric antigen receptor-positive T cells) with concurrent …

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Soft Lower-Limb Exoskeleton for Rehabilitation Training in Older Stroke Patients

Jiaxin Bai, Hengyue Chen, Jixian Wang, Guoyuan Yang et autres

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Pinch restoration in post-stroke hemiplegia rehabilitation: A case report of motor task-synchronized precision repetitive transcranial magnetic stimulation

Yang Liu, Jieshi He, Ying Wang, Zhiwei Xu et autres

Upper limb motor impairment, particularly hand dysfunction, remains a prevalent and debilitating sequela of stroke. Although conventional rehabilitation is widely applied, recovery of fine motor skills such as pinch function remains challenging [1]. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in …

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Targeted Inhibition of MEGF10 ‐Mediated Astrogliosis Reduces Glial Scar Formation and Promotes Neurofunction Recovery in Mice After Stroke

Jing-Jing Xu, Tongtong Xu, Lin Gan, Shiyu Deng et autres

The formation of glial scar at the chronic stage of neurological disease is mainly attributed to the activation and proliferation of astrocytes, termed astrogliosis. It is documented that astrogliosis-induced glial scar formation following stroke severely impairs neurological recovery. However, the mechanisms underlying …

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Interferon‐γ–Responsive Microglia‐Derived Extracellular Vesicles Inhibited Neurogenesis After Stroke via MicroRNA‐199a‐5p/ SIRT1 Axis

Tongtong Xu, Dongliang Qian, Shiyu Deng, Yiyan Guo et autres

Background Previous studies have reported the presence of interferon‐responsive microglia in the brain after central nervous system injury. However, their roles and the underlying mechanisms in neurological function recovery remain poorly understood. Methods Adult male mice were subjected to 90‐minute transient middle …

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Immuno‐Training Remodeled Vascular Microenvironment via Peptide‐Functionalized Hydrogel Microspheres for Neural Repair

Lin Gan, Tongtong Xu, Dandan Zheng, Ning Zhu et autres

ABSTRACT The vascular hyperinflammatory microenvironment significantly influences the regeneration and repair of central nervous system (CNS) following injury. Training immune behavior of immune cells under stress conditions is crucial for maintaining vascular microenvironment homeostasis and restoring vascular function. In this study, we …

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Investigating repetitive transcranial magnetic stimulation–induced interhemispheric changes in stroke: a transcranial magnetic stimulation and fNIRS study

Siqi Yang, Yaomei Li, Fen Zhang, Geert Verheyden et autres

Significance: Interhemispheric imbalance after stroke impedes motor recovery.Although repetitive transcranial magnetic stimulation (rTMS) shows therapeutic potential, the neural mechanisms underlying its effects-particularly on cortical excitability and interhemispheric interaction-remain unclear.Understanding these mechanisms is essential for optimizing personalized neuromodulation strategies in stroke rehabilitation.Aim: To …

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Single-Cell RNA Sequencing Characterizes Microglial Phenotypic Heterogeneity Across Different Stroke Subtypes

Yiyan Guo, Tongtong Xu, Chang Liu, Shiyu Deng et autres

Microglia-mediated neuroinflammation is a key contributor to secondary brain injury across diverse cerebrovascular pathologies, yet the precise transcriptomic diversity and temporal evolution of microglial states across different stroke subtypes remain to be fully elucidated. We utilized single-cell RNA sequencing to profile the …

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C-reactive protein-albumin-lymphocyte (CALLY) index predicts overall survival in elderly Japanese patients with dysphagia: a retrospective cohort study

Wenxiu Pan, Ya‐Wen Yang, Xiaohui Song, Jixian Wang et autres

Background: The C-reactive protein-albumin-lymphocyte (CALLY) index serves as an established prognostic biomarker across multiple severe disease cohorts. Nevertheless, limited research has examined its relationship with overall survival among elderly Japanese individuals experiencing dysphagia. Objective: To evaluate the prognostic utility of the CALLY …

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