Christian Alexander Vedeler

Dynamics of IgM and IgG responses in Lyme neuroborreliosis – a Norwegian longitudinal study

Ingerid Skarstein, Anne Marit Solheim, Åslaug Rudjord Lorentzen, Unn Ljøstad et autres

PURPOSE: We investigated longitudinal antibody responses against 13 different Borrelia burgdorferi (Bb) antigens in patients with Lyme neuroborreliosis (LNB) and explored whether antibody profiles were linked to length of symptoms and burden of symptoms prior to and after initiation of treatment. METHODS: …

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Biomarking MELAS with neurofilament light chain and circulating cell free mitochondrial DNA

Alessandra Maresca, Monica Moresco, Giulia Amore, Chiara La Morgia et autres

Mitochondrial diseases are genetic disorders caused either by nuclear or mitochondrial DNA (mtDNA) alterations and characterized by high genetic and phenotypic variability. The common mtDNA m.3243 A > G variant in the MT-TL1 gene leads to clinical manifestations ranging from the classical …

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RFC1 Spectrum Disorder in a Norwegian CANVAS Cohort

Sjur Prestsæter, Jeanette Koht, Siren Berland, Helle Høyer et autres

Background Late‐onset cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a progressive neurodegenerative disorder defined by sensory neuropathy, cerebellar ataxia, and bilateral vestibulopathy. While each symptom impairs balance, their combination causes substantial disability. The most common cause is a biallelic …

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En mann i 70-årene med svekket kraft og følelse i beina

Magne Solberg Nes, Jogrim Søyland, Mette Haugen, Christian Alexander Vedeler

Background: Over the last decade, antibodies targeting proteins at the node of Ranvier have been described in a subgroup of patients with autoimmune neuropathies, known as nodopathies. These disorders present an important differential diagnosis to chronic inflammatory demyelinating polyneuropathy (CIDP) due to …

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Altered exosomal miRNA profiles in patients with paraneoplastic cerebellar degeneration

Eirik Tveit Solheim, Liv Cecilie Vestrheim Thomsen, Line Bjørge, Shamundeeswari Anandan et autres

OBJECTIVE: Patients with ovarian cancer (OC) may develop anti-Yo-associated paraneoplastic cerebellar degeneration (PCD)-a cerebellar ataxia associated with tumor-induced autoimmunity against CDR2 and CDR2L proteins. Dysregulation of circulating exosomal microRNAs (miRNAs) occur in OC. Here, we investigated whether PCD is associated with changes …

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Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L

Eirik Tveit Solheim, Yola Gerking, Torbjørn Kråkenes, Ida Herdlevær et autres

BACKGROUND: Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) - a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens resulting in degeneration of Purkinje neurons in the cerebellum. The pathogenesis of PCD is unknown, in large part …

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General Effect Modelling (GEM) -- Part 3. GEM applied on proteome data of cerebrospinal fluid of multiple sclerosis and clinically isolated syndrome

Ellen F. Mosleth, Kjell‐Morten Myhr, Christian Alexander Vedeler, Frode S. Berven et autres

The novel data analytical platform General Effect Modelling (GEM), is an umbrella platform covering different data analytical methods that handle data with multiple design variables (or pseudo design variables) and multivariate responses. GEM is here demonstrated in an analysis of proteome data …

Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway

Ingerid Skarstein, Elling Ulvestad, Anne Marit Solheim, Christian Alexander Vedeler et autres

OBJECTIVES: Serum neurofilament light chain (sNfL), an indicator of neuronal damage, is increasingly recognized as a potential biomarker for disease activity in neurodegenerative disorders. In this study, we wanted to investigate sNfL as a prognostic marker in a large, well-defined population of …

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Paraneoplastic cerebellar and brainstem disorders

Justin Abbatemarco, Christian Alexander Vedeler, John Greenlee

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Case Report: Limbic encephalitis following treatment with durvalumab for small-cell lung cancer

Thomas T. Moss, Knut Stavem, Astrid Aandahl, Anne S. Gløersen et autres

Background Durvalumab is an immune checkpoint Inhibitor (ICIs) that is used in the treatment of malignant tumors, such as lung cancer and melanoma. ICIs are associated with immune-related adverse events including autoimmune encephalitis, although both paraneoplastic phenomena and ICI treatment may lead …

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Case report: Seropositive myasthenia gravis complicated by limbic encephalitis positive for antibodies to AMPAR and Lgi1

Magne Solberg Nes, Mette Haugen, Hans Kristian Haugland, Nils Erik Gilhus et autres

Objectives: Autoantibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and leucine-rich glioma-inactivated 1 (Lgi1) are associated with autoimmune encephalitis. We described an acetylcholine receptor (AChR)-positive patient with myasthenia gravis who developed limbic encephalitis with antibodies to AMPAR and Lgi1. Methods: A single-case report …

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Palatal tremor

Magne Solberg Nes, Christian Alexander Vedeler, Gaute Kjellevold Wathle

Førde sentralsjukehus Magne Solberg Nes er lege i spesialisering i nevrologi

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