Dynamics of IgM and IgG responses in Lyme neuroborreliosis – a Norwegian longitudinal study
Rattachement africain : no. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
PURPOSE: We investigated longitudinal antibody responses against 13 different Borrelia burgdorferi (Bb) antigens in patients with Lyme neuroborreliosis (LNB) and explored whether antibody profiles were linked to length of symptoms and burden of symptoms prior to and after initiation of treatment. METHODS: A well-characterized cohort of 106 patients of whom 85% had definite LNB were followed for twelve months, with serum and cerebrospinal fluid (CSF) sampled at baseline, six- and twelve-months follow-up. Antibodies were measured by the recomBead Borrelia IgG and IgM assay, with a subgroup examined for oligoclonal IgG production restricted to CSF. RESULTS: Antibody levels in both serum and CSF declined gradually after antibiotic treatment, with most of the reduction occurring within the first six months after treatment. Higher baseline IgM reactivity against p18 in both serum and CSF was associated with higher symptom burden prior to treatment. We found no differences in CSF antibody reactivity between patients with short (< 42 days) and long (≥ 42 days) symptom duration prior to treatment. In serum, patients with short symptom duration prior to treatment had higher IgM reactivity against p58 and higher IgG reactivity against OspC and p18. At baseline, 68% exhibited oligoclonal IgG production, falling to 41% six months after treatment. There was no correlation between oligoclonal IgG production and symptom burden. CONCLUSION: Both specific antibody production against a variety of antigens and intrathecal oligoclonal IgG production decreased after treatment for LNB, reflecting reduced antigenic load and thus reduced neuroinflammation. IgM and IgG reactivity against p18 were indicative of a shorter symptom duration and higher symptom burden prior to treatment.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Dynamics of IgM and IgG responses in Lyme neuroborreliosis – a Norwegian longitudinal study
- Date Crossref
- 20/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Haukeland University Hospital Department of Microbiology pays non établi dans la noticeÉtablissement de santé
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University of Bergen Department of Clinical Science pays non établi dans la noticeUniversité ou école supérieure
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University of Oslo Institute of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Sørlandet Sykehus pays non établi dans la noticeÉtablissement de santé
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University of Agder pays non établi dans la noticeUniversité ou école supérieure
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Western Norway University of Applied Sciences Department of Safety pays non établi dans la noticeUniversité ou école supérieure
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Norwegian Institute of Public Health Department of Research pays non établi dans la noticeOrganisme public
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Cancer Registry of Norway pays non établi dans la noticeInstitution
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Sørlandet Hospital Trust Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Faculty of Health and Sport Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Microbiology — Haukeland University Hospital, Department of Clinical Science — University of Bergen et Institute of Clinical Medicine — University of Oslo, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.