Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway
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Le résumé fourni par la source
OBJECTIVES: Serum neurofilament light chain (sNfL), an indicator of neuronal damage, is increasingly recognized as a potential biomarker for disease activity in neurodegenerative disorders. In this study, we wanted to investigate sNfL as a prognostic marker in a large, well-defined population of 90 patients with Lyme neuroborreliosis (LNB). In addition, we sought to explore associations between symptoms and sNfL levels during the acute phase of LNB. MATERIALS AND METHODS: Patients diagnosed with definite or possible LNB were recruited from a double-blinded, placebo-controlled, multi-center trial, in which the participants were randomly assigned to 2 or 6 weeks of oral doxycycline treatment. The sNfL levels were measured using a single molecule array assay at both diagnosis and 6-month follow-up, and analysed against clinical parameters, variations in symptom burden and long-term complaints as assessed by a composite clinical score. RESULTS: At the time of diagnosis, approximately 60% of the patients had elevated sNfL levels adjusted for age. Notably, mean sNfL levels were significantly higher at diagnosis (52 pg/ml) compared to 6 months after treatment (12 pg/ml, p < 0.001), when sNfL levels had normalized in the majority of patients. Patients with objective signs of spinal radiculitis had significantly higher baseline sNfL levels compared to patients without spinal radiculitis (p = 0.033). CONCLUSION: Our findings suggest that sNfL can serve as a biomarker for peripheral nerve tissue involvement in the acute phase of LNB. As found in an earlier study, we confirm normalization of sNfL levels in blood after treatment. We found no prognostic value of acute-phase sNfL levels on patient outcome.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway
- Date Crossref
- 26/02/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Haukeland University Hospital Department of Microbiology pays non établi dans la noticeÉtablissement de santé
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University of Bergen Department of Clinical Science pays non établi dans la noticeUniversité ou école supérieure
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Sørlandet Sykehus pays non établi dans la noticeÉtablissement de santé
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Hospital of Southern Norway pays non établi dans la noticeÉtablissement de santé
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University of Agder pays non établi dans la noticeUniversité ou école supérieure
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Oslo University Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Norwegian Institute of Public Health Cancer Registry of Norway pays non établi dans la noticeOrganisme public
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Cancer Registry of Norway pays non établi dans la noticeInstitution
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Sørlandet Hospital Trust Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Faculty of Health and Sport Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Microbiology — Haukeland University Hospital, Department of Clinical Science — University of Bergen et Sørlandet Sykehus, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.