Mary Beth Humphrey

Transcutaneous vagal nerve stimulation improves post-traumatic osteoarthritis pain in mice

Shivmurat Yadav, Lynsie M. Morris, Taylor Conner, Jessica Lumry et autres

Vagus nerve stimulation (VNS) has been shown to improve chronic pain, including fibromyalgia, migraine headaches, and gastrointestinal pain, as well as inflammation in RA. Here, we investigated the efficacy of transcutaneous VNS (tVNS) in providing pain relief in a mouse model of …

us (code pays fourni par la source)

VAGUS NERVE STIMULATION SUPPRESSES SYNOVIAL INFLAMMATION AND SLOWS OSTEOARTHRITIS PROGRESSION IN ACL-RUPTURED MICE

Shivmurat Yadav, Lynsie M. Morris, Gabby Dyson, Montana Renae Barrett et autres

us (code pays fourni par la source)

Emerging Role of TRP Channels in Osteoarthritis Pathogenesis

Shivmurat Yadav, Jyoti Yadav, Mary Beth Humphrey

Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, synovial inflammation, osteophyte formation, joint space narrowing, and persistent pain. During OA progression, synovial inflammation triggers the release of pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6, which activate matrix metalloproteinases (MMPs) …

us, au (code pays fourni par la source)

Osteoimmunology: the little niche with the big impact

Shivmurat Yadav, Jyoti Yadav, Mary Beth Humphrey

us (code pays fourni par la source)

Vagus nerve stimulation as a novel therapeutic approach for musculoskeletal diseases

Shivmurat Yadav, Stavros Stavrakis, Constance R. Chu, Mary Beth Humphrey

us (code pays fourni par la source)

Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice

Timothy M. Griffin, Ravi K. Komaravolu, Erika Barboza Prado Lopes, Padmaja Mehta-D’souza et autres

We hypothesized that daily exercise promotes joint health by upregulating anti-inflammatory mediators via adaptive molecular and metabolic changes in the infrapatellar fat pad (IFP). We tested this hypothesis by conducting time-resolved analyses between 1 and 14 days of voluntary wheel running exercise …

us (code pays fourni par la source)

Transcutaneous Vagus Nerve Stimulation Reduces Pain and OA Progression in Mouse Models of Post-Traumatic Osteoarthritis

Shivmurat Yadav, Lynsie M. Morris, Taylor Conner, Jessica Lumry et autres

Abstract Currently, there are no disease-modifying osteoarthritis (OA) drugs (DMOAD) to prevent OA progression and there are limitations on pain relieving therapeutics. Vagus nerve stimulation (VNS) delivered by an implantable device is FDA-approved for refractory epilepsy and severe depression. Here, we investigated …

us (code pays fourni par la source)

Current Treatment for Glucocorticoid-Induced Osteoporosis: Beyond Bisphosphonates

Mary Beth Humphrey

us (code pays fourni par la source)

Medication-induced fractures: Screening and treatment strategies

Laraib Javed, Aemen Khakwani, Uzair Khan, Mary Beth Humphrey

us (code pays fourni par la source)

Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury

Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall et autres

Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profiles from DKD patients and two DKD …

us, gb, cn (code pays fourni par la source)

SHIP inhibition mediates select TREM2-induced microglial functions

Gautham S Ramakrishnan, William L. Berry, Angela Pacherille, William Garrow Kerr et autres

Microglia play a pivotal role in the pathology of Alzheimer's Disease (AD), with the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) central to their neuroprotective functions. The R47H variant of TREM2 has emerged as a significant genetic risk factor for AD, …

us (code pays fourni par la source)

Vagal Nerve Stimulation Mitigates Pain in Mouse Models of Post-Traumatic Osteoarthritis

Mary Beth Humphrey, Shivmurat Yadav, Monika Niewiadomska, Lynsie M. Morris et autres

us (code pays fourni par la source)