Lynsie M. Morris

Transcutaneous vagal nerve stimulation improves post-traumatic osteoarthritis pain in mice

Shivmurat Yadav, Lynsie M. Morris, Taylor Conner, Jessica Lumry et autres

Vagus nerve stimulation (VNS) has been shown to improve chronic pain, including fibromyalgia, migraine headaches, and gastrointestinal pain, as well as inflammation in RA. Here, we investigated the efficacy of transcutaneous VNS (tVNS) in providing pain relief in a mouse model of …

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VAGUS NERVE STIMULATION SUPPRESSES SYNOVIAL INFLAMMATION AND SLOWS OSTEOARTHRITIS PROGRESSION IN ACL-RUPTURED MICE

Shivmurat Yadav, Lynsie M. Morris, Gabby Dyson, Montana Renae Barrett et autres

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PO-02-120 TRANSCUTANEOUS VAGUS NERVE STIMULATION: A PERSONALIZED APPROACH TO AUTONOMIC MODULATION

Maria Toumpourleka, Gunjan Kochhar, Seabrook Whyte, Lynsie M. Morris et autres

Vagal Stimulation Rescues HFpEF by Altering Cardiac Resident Macrophage Function

Thamizhiniyan Venkatesan, Maria Toumpourleka, Monika Niewiadomska, Kassem Farhat et autres

BACKGROUND: We previously showed in a rat model of heart failure with preserved ejection fraction (HFpEF) that transcutaneous vagus nerve stimulation (tVNS) reduced cardiac fibrosis and inflammation. However, macrophage-mediated mechanisms through which tVNS rescues cardiac function remain poorly understood. METHODS: We induced …

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Atrial fibrillation-induced autonomic remodeling is reversed by noninvasive vagus nerve stimulation

Maria Toumpourleka, Lynsie M. Morris, Scott Whyte, Kulsoom Farhat et autres

Abstract Background Atrial fibrillation (AF) is the most common sustained arrhythmia, yet its underlying mechanisms remain poorly understood, leaving treatment options often suboptimal. The autonomic nervous system, and particularly the ganglionated plexi (GP) within the heart, may hold a critical role in …

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Targeting CCR2+ macrophages and SPP1 in HFpEF: the promise of vagus nerve stimulation

Maria Toumpourleka, Thirumalai Venkatesan, Monika Niewiadomska, Katja Farhat et autres

Abstract Background Heart failure with preserved ejection fraction (HFpEF) affects around 50% of heart failure patients, and is associated with high morbidity and limited therapeutic options. Immune and inflammatory mechanisms, particularly cardiac resident macrophages (CRM), have been implicated in HFpEF pathology, though …

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BS-499652-004 IMMUNOMODULATORY EFFECTS OF TRANSCUTANEOUS VAGUS NERVE STIMULATION IN HEART FAILURE WITH PRESERVED EJECTION FRACTION

Thamizhiniyan Venkatesan, Maria Toumpourleka, Lynsie M. Morris, Seabrook Whyte et autres

Transcutaneous Vagus Nerve Stimulation Reduces Pain and OA Progression in Mouse Models of Post-Traumatic Osteoarthritis

Shivmurat Yadav, Lynsie M. Morris, Taylor Conner, Jessica Lumry et autres

Abstract Currently, there are no disease-modifying osteoarthritis (OA) drugs (DMOAD) to prevent OA progression and there are limitations on pain relieving therapeutics. Vagus nerve stimulation (VNS) delivered by an implantable device is FDA-approved for refractory epilepsy and severe depression. Here, we investigated …

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MP-470548-001 DIAGNOSTIC ACCURACY OF A MOBILE, ARTIFICIAL INTELLIGENCE-GUIDED, 12-LEAD ECG DEVICE

Seabrook Whyte, Karlie Sample, Irina Mustafina, Lynsie M. Morris et autres

Effect of Low-Level Tragus Stimulation on Cardiac Metabolism in Heart Failure with Preserved Ejection Fraction: A Transcriptomics-Based Analysis

Praloy Chakraborty, Monika Niewiadomska, Kassem Farhat, Lynsie M. Morris et autres

Abnormal cardiac metabolism precedes and contributes to structural changes in heart failure. Low-level tragus stimulation (LLTS) can attenuate structural remodeling in heart failure with preserved ejection fraction (HFpEF). The role of LLTS on cardiac metabolism is not known. Dahl salt-sensitive rats of …

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Vagal Nerve Stimulation Mitigates Pain in Mouse Models of Post-Traumatic Osteoarthritis

Mary Beth Humphrey, Shivmurat Yadav, Monika Niewiadomska, Lynsie M. Morris et autres

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Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome

Praloy Chakraborty, Kassem Farhat, Lynsie M. Morris, Seabrook Whyte et autres

Postural orthostatic tachycardia syndrome (POTS) is a chronic debilitating condition of orthostatic intolerance, predominantly affecting young females. Other than postural tachycardia, symptoms of POTS include a spectrum of non-cardiac, systemic and neuropsychiatric features. Despite the availability of widespread pharmacological and non-pharmacological therapeutic …

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