Constance R. Chu

Neural Shape Modeling Reveals Early and Progressive Femoral Bone Shape and Cartilage Thickness Changes After Anterior Cruciate Ligament Reconstruction

Anoosha Pai S, McKenzie S. White, Marianne S. Black, Katherine A. Young et autres

ABSTRACT Early and longitudinal shape changes in femoral bone and cartilage after anterior cruciate ligament reconstruction (ACLR) remains poorly understood. It is also unknown whether post traumatic shape changes follow similar trajectory as progressive alterations seen in idiopathic osteoarthritis (OA). Two neural …

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Poster 02. Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Subtle Differences by Sex

Paula A. Hernandez, Constance R. Chu, Chun-Yuan Huang, Chao Xing et autres

Objective: Females have a higher risk to sustain anterior cruciate ligament (ACL) tears and a higher prevalence and incidence of developing knee osteoarthritis (OA) later in life, compared to age-matched males. Anatomical, biomechanical, and hormonal factors are known to be behind these …

Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Differences by Sex

Paula Andrea Velilla Hernández, Constance R. Chu, Chun-Yuan Huang, Chao Xing et autres

ABSTRACT Objective Anterior cruciate ligament (ACL) tears increase the risk for developing posttraumatic osteoarthritis (PTOA). Females have greater risk for both. However, studies defining sex-specific protein responses in human cartilage after ACL injury are lacking. We hypothesize that articular cartilage’s response to …

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Handheld Ultrasound for Personalized All-Soft-Tissue Quadriceps Tendon Anterior Cruciate Ligament Reconstruction

Constance R. Chu, Leina’ala Song, Jade He, Eugene Roh

Background: The use of quadriceps tendon autograft for anterior cruciate ligament (ACL) reconstruction (ACLR) has substantially increased in popularity. Advantages include similar clinical outcomes to other autografts and greater intra-articular tendon volume. However, injury to the quadriceps muscle during graft harvest may …

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BMI and Varus Malalignment Compound to Define a High-Risk Phenotype for Compartment-Specific Knee Osteoarthritis Progression

McKenzie S. White, Feliks Kogan, Scott L. Delp, Constance R. Chu et autres

Objectives: Knee osteoarthritis (KOA) is a leading cause of disability, yet which patients will experience structural decline remains unclear. Body mass index (BMI) and lower limb alignment are established risk factors for KOA, but their independent and interactive effects on compartment-specific cartilage …

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What’s New in Biologics

Constance R. Chu, Farshid Guilak, Johnny Huard, Daniel Grande

At the turn of the twenty-first century, biologics were anticipated to herald substantial advances that could reduce reliance on orthopaedic surgery to treat both acute and chronic musculoskeletal problems. For example, the use of biologics in the form of tumor necrosis factor-alpha …

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A single versus multi-vector approach to treating post-traumatic osteoarthritis using scAAV2 IL-1ra or scAAV2 IL-1ra/IGF-I in an equine preclinical model

Jaiden Oropallo, Parvathy Thampi, J. Phillips, Myra F. Barrett et autres

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Preventing osteoarthritis after anterior cruciate ligament injury: The case for targeting pre-osteoarthritis illness

Matthew S. Harkey, Harvi F. Hart, Christopher M. Kuenze, Grace H. Lo et autres

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Neural Shape Modeling Reveals Early and Progressive Femoral Bone Shape and Cartilage Thickness Changes After Anterior Cruciate Ligament Reconstruction

Anoosha Pai S, McKenzie S. White, Marianne S. Black, Katherine A. Young et autres

ABSTRACT Objectives To assess early and longitudinal post-traumatic osteoarthritis (POTA) changes in the femoral bone and cartilage following after anterior cruciate ligament reconstruction (ACLR). Methods CLR and contralateral knees of 17 subjects (11M, 38±11years), and 17 matched healthy controls underwent 3T-MRI at …

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3D Hybrid Bioprinting for Complex Multi-Tissue Engineering

Hossein Vahid Alizadeh, Andrea S. Flores Pérez, Tomohiro Uno, Richard Sammy Muniz et autres

3D bioprinting has revolutionized tissue engineering, enabling intricate, physiologically relevant constructs unattainable with conventional techniques, yet it remains limited in integrating soft and rigid multifunctional components for complex multi-tissue applications. In this study, we introduce a 3D hybrid bioprinting approach implementing the …

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Daily Step Count 2 Years After Anterior Cruciate Ligament Reconstruction and Associations With Cartilage Health and Knee Symptoms and Function

Britt Elin Øiestad, Ashley A. Williams, Matthew R. Titchenal, Amelie M. Lutz et autres

BACKGROUND: People suffering anterior cruciate ligament (ACL) injuries are at increased risk for development of osteoarthritis (OA). This study investigated associations between daily step count, cartilage degeneration and patient-reported outcomes 2 years after ACL reconstruction (ACLR). HYPOTHESIS: Daily step count is associated …

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Validation of an Automated Open Source Pipeline for Comprehensive Knee MRI Segmentation and Measurement of Quantitative Outcomes

Francesca Belibi, Vyoma Sahani, Yael Vainberg, Ananya Goyal et autres

Motivation: Our motivation was to determine a way to decrease the time dedicated to tissue segmentation and data analysis. Goal(s): Our goal was to test the validity of the DOSMA automated segmentation pipeline for OA analysis. Approach: Building on previous DOSMA frameworks …