Accès ouvert
2026
article
OpenAlex
Carlos J Rodriguez Hernandez, Alonso Cruz-Cruz, Chandra L. Shrestha, Marina Terekhova et autres
Physical interactions with bacterial colonizers at mucosal barrier surfaces can have beneficial or detrimental effects on viral infectivity and transmission. The oropharyngeal mucosal surface is a major portal of entry for many pathogenic respiratory viruses, such as respiratory syncytial virus (RSV), and …
us
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Accès ouvert
2025
article
OpenAlex
Kendall S. Stocke, Satya Deo Pandey, Shunying Jin, John D. Perpich et autres
Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and effector mechanisms are not well understood. Flux through the one-carbon metabolism (OCM) pathway can modulate …
us, pl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xiangan Liu, John D. Perpich, Liqiang Song, Christian Cambillau et autres
ABSTRACT The type IX secretion system (T9SS) is a protein secretion machinery unique to the Bacteroidetes-Chlorobi-Fibrobacteres superphylum, which plays crucial roles in bacterial pathogenesis and gliding motility. It is composed of >15 proteins, including the proton-motive force-dependent PorLM motor, the PorKN ring …
us, ie, fr
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Accès ouvert
2025
preprint
OpenAlex
Carlos J. Rodriguez-Hernandez, Marina Terekhova, Phylip Chen, John D. Perpich et autres
ABSTRACT We demonstrate that proteases produced by the oro-pharyngeal bacterial colonizer Porphyromonas gingivalis (Pg) reduce viral burden and modulate host interferon responses during respiratory syncytial virus (RSV) infection. Several oral bacteria, including Pg , have been shown to translocate to the upper …
us
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Accès ouvert
2025
preprint
OpenAlex
Kendall S. Stocke, Satya Deo Pandey, Shunying Jin, John D. Perpich et autres
Abstract Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and effector mechanisms are not well understood. Flux through the One Carbon Metabolism (OCM) pathway …
us, pl
(code pays fourni par la source)
2024
article
OpenAlex
William C. Beckerson, Jennifer Ellen Anderson, Siddhesh Kulkarni, John D. Perpich et autres
Active learning is the new standard for teaching in higher education. As more faculty seek to expand their teaching practices by including active-learning activities that promote higher levels of learning, many are doing so in small doses by temporarily postponing traditional lectures …
us
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Accès ouvert
2023
article
OpenAlex
Satya Deo Pandey, John D. Perpich, Kendall S. Stocke, Jillian M. Mansfield et autres
Bacteria responsible for diseases originating at oral mucosal membranes assemble into polymicrobial communities. However, we know little regarding the fitness determinants of the organisms that initiate community formation. Here, we show that the extracellular polysaccharide of Streptococcus gordonii, while important for streptococcal …
us
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Accès ouvert
2022
article
OpenAlex
John D. Perpich, Lan Yakoumatos, Kendall S. Stocke, Gina R. Lewin et autres
, encoding an internalin family surface protein. Ptk1, but not InlJ, is required for community development with S. gordonii, and we found that the action of this kinase is similarly required for P. gingivalis to accumulate in a community with F. nucleatum. …
us
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Accès ouvert
2022
article
OpenAlex
Liqiang Song, John D. Perpich, Chenggang Wu, Thierry Doan et autres
The Porphyromonas gingivalis type IX secretion system (T9SS) promotes periodontal disease by secreting gingipains and other virulence factors. By in situ cryoelectron tomography, we report that the P. gingivalis T9SS consists of 18 PorM dimers arranged as a large, caged ring in …
us, fr, pl
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Olivier Huck, Hannah Mulhall, GEORGE L. RUBIN, Zev Kizelnik et autres
Non peer reviewed
fr, us, be, fi, nl
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Accès ouvert
2021
article
OpenAlex
John D. Perpich, Lan Yakoumatos, Parker Johns, Kendall S. Stocke et autres
Phosphorylation of proteins is a key component of bacterial signaling systems that can control important functions such as community development and virulence. We report here the identification of a Ubiquitous bacterial Kinase (UbK) family member, designated UbK1, in the anaerobic periodontal pathogen, …
us
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Accès ouvert
2020
article
OpenAlex
Daonan Shen, John D. Perpich, Kendall S. Stocke, Lan Yakoumatos et autres
Porphyromonas gingivalis expresses a limited number of two-component systems, including RprY, an orphan response regulator which lacks a cognate sensor kinase. In this study, we examined cross-phosphorylation of RprY on tyrosine residues and its importance for RprY function. We show that RprY …
us
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