Ernesto Soto‐Reyes

BORIS/CTCFL Reprograms Glioblastoma Transcriptional Networks through the Regulation of Tumor-Associated Genes such as CD36 and FBN2

Gerardo Ramírez-Mejía, Sofía Plata-Burgos, Raquel Cuevas‐Díaz Durán, Adrian Ledesma-Beiza et autres

Objectives: Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation. Brother of the Regulator of Imprinted Sites (BORIS/CTCFL) has been implica... | Find, read and cite all the research you need on Tech Science Press

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Loss of miR-122 promotes cell migration and poor prognosis in triple-negative breast cancer treated by neoadjuvant chemotherapy

Mauricio Flores‐Fortis, Isidro X. Perez‐Añorve, Carlos César Patiño-Morales, Ernesto Soto‐Reyes et autres

BACKGROUND: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. miR-122 is abnormally expressed in breast cancer, functioning as both a tumor suppressor and oncomiR, however, its role in triple-negative breast cancer (TNBC) remains unclear. PURPOSE: In this study we …

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Identification of enhancer chromatin signatures involved in dopaminergic induction through multi-omics analysis

Mayela Giacoman-Lozano, César Meléndez-Ramírez, Adolfo López-Ornelas, Aylin Del Moral‐Morales et autres

Abstract The establishment of precise transcriptional programs during neuronal development depends on a complex and dynamic landscape of regulatory elements. Here, we combined histone modification ChIP-seq, chromatin accessibility profiling, and transcriptomics to map active enhancer repertoires during the differentiation of human embryonic …

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Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl ( Ambystoma mexicanum )

Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes et autres

The axolotl (Ambystoma mexicanum) has a great capacity to regenerate its tissues; however, the fidelity and success of its regenerative process diminish with age. Retrotransposons make up the largest portion of the axolotl genome, and their expression may be involved in this …

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The Role of Folic Acid in DNA Methylation and Breast Cancer

S Guzmán, Brenda Pelayo-Chávez, Andrea Marlene García-Muro, Ernesto Soto‐Reyes et autres

Folate and folic acid (FA) are two forms of vitamin B9, a B-complex nutrient essential for the human body. Folate is the natural form of vitamin B9 and is found in foods such as citrus fruits, leafy green vegetables, and beans. In …

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Integrated Transcriptome Analysis of Radioresistant Cells Revealed Genes and Pathways Predictive Of Tumor Response to Radiotherapy and Chemotherapy in Breast Cancer

Isidro X. Perez‐Añorve, Mauricio Flores‐Fortis, Carlos César Patiño-Morales, Elizabeth Ortiz-Gutiérrez et autres

Abstract Breast cancer cells exposed to radiotherapy frequently develop radiation resistance through molecular and phenotypic changes. While there is evidences of pathways controlling radioresistance, the evolution of diverse cell phenotypes and transcriptional changes as mediators of radioresistance in breast cancer are restricted. …

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Retrotransposon expression is upregulated by aging and suppressed during regeneration of the limb in the axolotl ( Ambystoma mexicanum )

Samuel Ruiz‐Pérez, Karla Torres‐Arciga, Cynthia Sámano, José Antonio Ocampo‐Cervantes et autres

Abstract The axolotl ( Ambystoma mexicanum ) has a great capacity to regenerate its tissues and whole-body parts; however, the fidelity and success of its regenerative process diminish with age. Retrotransposons make up the largest portion of the axolotl genome, and their …

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Key Proteins for Regeneration in A. mexicanum

Aylin Del Moral‐Morales, Cynthia Sámano, José Antonio Ocampo‐Cervantes, Maya Topf et autres

The axolotl, known for its remarkable regenerative abilities, is an excellent model for studying regenerative therapies. Nevertheless, the precise molecular mechanisms governing its regenerative potential remain uncertain. In this study, we collected samples from axolotls of different ages, including 8‐year‐old individuals and …

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Key Proteins for Regeneration in A. mexicanum : Transcriptomic Insights from Aged and Juvenile Limbs

Aylin Del Moral‐Morales, Cynthia Sámano, José Antonio Ocampo‐Cervantes, Maya Topf et autres

Abstract The axolotl is an animal with remarkable regenerative abilities, making it an ideal model for studying potential regenerative therapies in mammals, including humans. However, the molecular mechanisms involved in regeneration remain unclear. We conducted a transcriptomic analysis of juvenile axolotls’ limbs …

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CTCF and Its Multi-Partner Network for Chromatin Regulation

Aylin Del Moral‐Morales, Marisol Salgado-Albarrán, Yesennia Sánchez-Pérez, Nina K. Wenke et autres

Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity …

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Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker

José Alberto Carlos-Escalante, Sonia Iliana Mejía‐Pérez, Ernesto Soto‐Reyes, Lissania Guerra-Calderas et autres

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Airborne particulate matter (PM10) induces cell invasion through Aryl Hydrocarbon Receptor and Activator Protein 1 (AP-1) pathway deregulation in A549 lung epithelial cells

Rocío Morales‐Bárcenas, Yesennia Sánchez-Pérez, Miguel Santibáñez-Andrade, Yolanda I. Chirino et autres

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