Marisol Salgado-Albarrán

Streamlining and generalizing network-based drug discovery with NeDRex and Drugst.One

Fernando M. Delgado-Chaves, Sepideh Sadegh, James Skelton, Andreas Maier et autres

NeDRex (Network-based Drug Repurposing Explorer) (Sadegh et al. 2021, 2022) is a network-based computational tool used for drug repurposing. The NeDRex database houses a rich collection of data on Protein-Protein and Drug-Protein (target) interactions and integrates diverse data sources. The outcome is …

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Streamlining and generalizing network-based drug discovery with NeDRex and Drugst.One

Fernando M. Delgado-Chaves, Sepideh Sadegh, James Skelton, Andreas Maier et autres

NeDRex (Network-based Drug Repurposing Explorer) (Sadegh et al. 2021, 2022) is a network-based computational tool used for drug repurposing. The NeDRex database houses a rich collection of data on Protein-Protein and Drug-Protein (target) interactions and integrates diverse data sources. The outcome is …

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CTCF and Its Multi-Partner Network for Chromatin Regulation

Aylin Del Moral‐Morales, Marisol Salgado-Albarrán, Yesennia Sánchez-Pérez, Nina K. Wenke et autres

Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D structure of chromatin. Because of its multivalent properties and plasticity …

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Targeting infectious diseases: The CoVex example

Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez et autres

In a pandemic, such as the one caused by the coronavirus in 2020, fast action is required to provide insights into the disease mechanisms and to find potential drug targets to slow the progress of the disease and lower mortality. We developed …

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Transcriptomic and Drug Discovery Analyses Reveal Natural Compounds Targeting the KDM4 Subfamily as Promising Adjuvant Treatments in Cancer

Aylin Del Moral‐Morales, Marisol Salgado-Albarrán, Elizabeth Ortiz-Gutiérrez, Gerardo Pérez‐Hernández et autres

KDM4 proteins are a subfamily of histone demethylases that target the trimethylation of lysines 9 and 36 of histone H3, which are associated with transcriptional repression and elongation respectively. Their deregulation in cancer may lead to chromatin structure alteration and transcriptional defects …

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CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy

Marisol Salgado-Albarrán, Julian Späth, Rodrigo González‐Barrios, Jan Baumbach et autres

High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy due to the lack of reliable biomarkers, effective treatment, and chemoresistance. Improving the diagnosis and the development of targeted therapies is still needed. The molecular pathomechanisms driving HGSC progression are not …

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Example dataset for DASiRe

Marisol Salgado-Albarrán, Chit Tong Lio, Amit Fenn

Direct Alternative Splicing Regulator predictor (DASiRe) is a web application that allows non-expert users to perform different types of splicing analysis from RNA-seq experiments and also incorporates ChIP-seq data of a DNA-binding protein of interest to evaluate whether its presence is associated …

Example dataset for DASiRe

Marisol Salgado-Albarrán, Chit Tong Lio, Amit Fenn

Direct Alternative Splicing Regulator predictor (DASiRe) is a web application that allows non-expert users to perform different types of splicing analysis from RNA-seq experiments and also incorporates ChIP-seq data of a DNA-binding protein of interest to evaluate whether its presence is associated …

Network medicine for disease module identification and drug repurposing with the NeDRex platform

Sepideh Sadegh, James Skelton, Elisa Anastasi, Judith Bernett et autres

Traditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs provides an alternative with lower costs and faster drug development timelines. However, the data necessary for the identification of disease modules, i.e. pathways and sub-networks describing the mechanisms of complex …

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Bioinformatics of Transcription Factor Binding Prediction

Erick I. Navarro‐Delgado, Marisol Salgado-Albarrán, Karla Torres‐Arciga, Nicolás Alcaraz et autres

Transcription Factors (TFs) are crucial proteins that regulate gene expression in the cell. They bind to regulatory sequences and promote the transcription of genomic elements. The identification of TFs binding sites is often the first step towards a detailed understanding of their …

The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis

Doglas Parise, Mariana Teixeira Dornelles Parise, Anne Cybelle Pinto Gomide, Flávia Figueira Aburjaile et autres

Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis (UL) in horses, and caseous lymphadenitis (CLA) in …

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Lessons from the COVID-19 pandemic for advancing computational drug repurposing strategies

Gihanna Galindez, Julian Matschinske, Tim Rose, Sepideh Sadegh et autres

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