Sadie P. Antine

The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond

Jill Chrencik, Hua-Poo Su, Yacob Gómez Llorente, R.L. Palte et autres

Structural biology has fundamentally influenced pharmaceutical research and development at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, progressing from pioneering macromolecular crystallography in the 1980s to a fully integrated platform that today encompasses X-ray crystallography, cryo-electron microscopy, micro-electron diffraction and …

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Nuclease–NTPase antiphage defence systems use conserved molecular features to control bacterial immunity

Adelyn E. Ragucci, Sadie P. Antine, Ethan M. Leviss, Sarah E. Mooney et autres

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Nuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense

Adelyn E. Ragucci, Sadie P. Antine, Ethan M. Leviss, Sarah E. Mooney et autres

Nuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense

Adelyn E. Ragucci, Sadie P. Antine, Ethan M. Leviss, Sarah E. Mooney et autres

A prophage-encoded abortive infection protein preserves host and prophage spread

Molly R. Sargen, Sadie P. Antine, Grzegorz Jan Grabe, Gabriella Antonellis et autres

Most bacterial pathogens are polylysogens, harbouring multiple vertically transmitted prophages1–3. These prophages enhance bacterial pathogenicity and survival by encoding virulence factors and anti-phage defence systems while retaining the capacity for horizontal transfer. Thus, prophage-encoded anti-phage defences must block propagation of external phages …

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Nuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense

Adelyn E. Ragucci, Sadie P. Antine, Ethan M. Leviss, Sarah E. Mooney et autres

Bacteria encode an enormous diversity of defense systems including restriction-modification and CRISPR-Cas that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate many recently identified anti-phage defense operons are comprised of a predicted nuclease and an accessory NTPase protein, suggesting …

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Phages overcome bacterial immunity via diverse anti-defence proteins

Erez Yirmiya, Azita Leavitt, Allen P. Lu, Adelyn E. Ragucci et autres

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Structural basis of Gabija anti-phage defence and viral immune evasion

Sadie P. Antine, Alex G. Johnson, Sarah E. Mooney, Azita Leavitt et autres

Abstract Bacteria encode hundreds of diverse defence systems that protect them from viral infection and inhibit phage propagation 1–5 . Gabija is one of the most prevalent anti-phage defence systems, occurring in more than 15% of all sequenced bacterial and archaeal genomes …

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Phages overcome bacterial immunity via diverse anti-defense proteins

Erez Yirmiya, Azita Leavitt, Allen P. Lu, Carmel Avraham et autres

Abstract It was recently shown that bacteria employ, apart from CRISPR-Cas and restriction systems, a considerable diversity of phage resistance systems, but it is largely unknown how phages cope with this multilayered bacterial immunity. Here, we analyzed groups of closely related Bacillus …

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Structural basis of Gabija anti-phage defense and viral immune evasion

Sadie P. Antine, Alex G. Johnson, Sarah E. Mooney, Azita Leavitt et autres

Bacteria encode hundreds of diverse defense systems that protect from viral infection and inhibit phage propagation 1–5 . Gabija is one of the most prevalent anti-phage defense systems, occurring in >15% of all sequenced bacterial and archaeal genomes 1,6,7 , but the …

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Viruses inhibit TIR gcADPR signalling to overcome bacterial defence

Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen P. Lu et autres

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Moonlighting translation factors: multifunctionality drives diverse gene regulation

Dorian Farache, Sadie P. Antine, Amy S.Y. Lee

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