Grzegorz Jan Grabe

Flagellar system translocates T3SS effectors critical for Salmonella infection, source data and Appendix A

Alona Dreus, Paulina Matheova, Martina Spejzlova, Grzegorz Jan Grabe et autres

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Flagellar system translocates T3SS effectors critical for Salmonella infection, source data and Appendix A

Alona Dreus, Paulina Matheova, Martina Spejzlova, Grzegorz Jan Grabe et autres

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A prophage-encoded abortive infection protein preserves host and prophage spread

Molly R. Sargen, Sadie P. Antine, Grzegorz Jan Grabe, Gabriella Antonellis et autres

Most bacterial pathogens are polylysogens, harbouring multiple vertically transmitted prophages1–3. These prophages enhance bacterial pathogenicity and survival by encoding virulence factors and anti-phage defence systems while retaining the capacity for horizontal transfer. Thus, prophage-encoded anti-phage defences must block propagation of external phages …

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Molecular stripping underpins derepression of a toxin–antitoxin system

Grzegorz Jan Grabe, Rachel T. Giorgio, Miłosz Wieczór, Bridget Gollan et autres

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Stapled Phd Peptides Inhibit Doc Toxin Induced Growth Arrest in Salmonella

Dennis J. Worm, Grzegorz Jan Grabe, Guilherme V. Castro, Sofya Rabinovich et autres

High Resolution Image Download MS PowerPoint Slide Bacterial toxin inhibition is a promising approach to overcoming antibiotic failure. In Salmonella, knockout of the toxin Doc has been shown to significantly reduce the formation of antibiotic-tolerant persisters. Doc is a kinase that is …

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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates Offer Alternative Leukemia Therapy during Hematopoietic Cell Transplantation

Jan Jakub Lica, Mateusz Heldt, Miłosz Wieczór, Paweł Chodnicki et autres

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Characterization of the Key Determinants of Phd Antitoxin Mediated Doc Toxin Inactivation in Salmonella

Guilherme V. Castro, Dennis J. Worm, Grzegorz Jan Grabe, Fiona C. Rowan et autres

High Resolution Image Download MS PowerPoint Slide In the search for novel antimicrobial therapeutics, toxin-antitoxin (TA) modules are promising yet underexplored targets for overcoming antibiotic failure. The bacterial toxin Doc has been associated with the persistence of Salmonella in macrophages, enabling its …

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A Bacterial Cell-Based Assay To Study SARS-CoV-2 Protein-Protein Interactions

Benjamin L. Springstein, Padraig Deighan, Grzegorz Jan Grabe, Ann Hochschild

Understanding how virally encoded proteins interact with one another is essential in elucidating basic viral biology, providing a foundation for therapeutic discovery. Here, we describe the use of a versatile bacterial cell-based system to investigate the interactions of the protein set encoded …

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A bacteria-based assay to study SARS-CoV-2 protein-protein interactions

Benjamin L. Springstein, Padraig Deighan, Grzegorz Jan Grabe, Ann Hochschild

Abstract Methods for detecting and dissecting the interactions of virally encoded proteins are essential for probing basic viral biology and providing a foundation for therapeutic advances. The dearth of targeted therapeutics for the treatment of COVID-19, an ongoing global health crisis, underscores …

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Auxiliary interfaces support the evolution of specific toxin–antitoxin pairing

Grzegorz Jan Grabe, Rachel T. Giorgio, Alexander M. J. Hall, Rhodri M. L. Morgan et autres

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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Jan Jakub Lica, Miłosz Wieczór, Grzegorz Jan Grabe, Marta Jancz et autres

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to …

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Structure of the cytoplasmic domain of SctV (SsaV) from the Salmonella SPI-2 injectisome and implications for a pH sensing mechanism

Teige R. S. Matthews-Palmer, Nayim González-Rodríguez, Thomas Calcraft, Signe Lagercrantz et autres

Bacterial type III secretion systems assemble the axial structures of both injectisomes and flagella. Injectisome type III secretion systems subsequently secrete effector proteins through their hollow needle into a host, requiring co-ordination. In the Salmonella enterica serovar Typhimurium SPI-2 injectisome, this switch …

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