Jiang Chang

MDA5 regulates BCR signaling and B-cell function via NF-κB-mediated DNM1

Li Luo, Yi Wang, Guofeng Fang, Jiang Chang et autres

cn (code pays fourni par la source)

AIM2 positively regulates B cell activation and function through the SNX9-PI3K-WASP axis

Yanmei Huang, Pengyue Gao, Li Luo, Yuxin Bai et autres

cn (code pays fourni par la source)

Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

BACKGROUND: ]octreotate has been established as treatment for patients with metastatic neuroendocrine tumors (NETs) that overexpress the somatostatin receptor (SSTR). While PRRT improves survival and quality of life, curative responses remain rare. One way to enhance PRRT efficacy is to combine it …

nl (code pays fourni par la source)

Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

nl (code pays fourni par la source)

Comprehensive analysis of the functional and immunological significance of ETV4 in pan-cancer and its validation in digestive tumors

Lingli Huang, Xujia Li, Silan Huang, Qi Jiang et autres

Background The E26 transformation-specific (ETS) transcription factor family is widely expressed and implicated in tumorigenesis. Among them, ETV4 plays a crucial role in cancer progression. However, its broader impact on prognosis and immune regulation across different malignancies remains insufficiently understood. Methods Based …

cn (code pays fourni par la source)

NRXN3 regulates pyroptosis in intrahepatic cholangiocarcinoma via mediating the phospho-dependent ubiquitination and degradation of caspase-3

Tao Zhou, Yaodong Zhang, Tianlin Wang, Jiang Chang et autres

INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) remains one of the most lethal malignancies with an increasing incidence worldwide. Gemcitabine has been considered the standard first-line chemotherapeutic agent for ICC but the therapeutic response is unsatisfactory due to the development of chemoresistance. Caspase-3-mediated pyroptosis has …

cn (code pays fourni par la source)

Abstract 2816 CRISPR screens identify GSR as a vulnerability for KEAP1/NRF2 mutant NSCLC

Yun Huang, Ting Chao, Jiang Chang

OBJECTIVE: The study aims to identify key antioxidant enzymes whose inhibition reverses the profound resistance of non-small-cell lung cancer (NSCLC) with KEAP1/NRF2 mutations to oxidative stress, a key mediator of chemo/radiation therapy.METHODS: We conducted negative selection CRISPR-based screens using an antioxidant enzyme-focused …

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Mathematical Model of Cell Death as a Consequence of DNA Damage

Marko Rašeta, Jacinta van de Grint, Shannon Dealy, Jiang Chang et autres

de (code pays fourni par la source)

Additional file 1 of Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Supplementary Material 1.

nl (code pays fourni par la source)

Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Abstract Background Peptide receptor radionuclide therapy (PRRT) employing [177Lu]Lu-[DOTA-Tyr3]octreotate has been established as treatment for patients with metastatic neuroendocrine tumors (NETs) that overexpress the somatostatin receptor (SSTR). While PRRT improves survival and quality of life, curative responses remain rare. One way to …

nl (code pays fourni par la source)

Additional file 1 of Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Supplementary Material 1.

nl (code pays fourni par la source)

Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Abstract Background Peptide receptor radionuclide therapy (PRRT) employing [177Lu]Lu-[DOTA-Tyr3]octreotate has been established as treatment for patients with metastatic neuroendocrine tumors (NETs) that overexpress the somatostatin receptor (SSTR). While PRRT improves survival and quality of life, curative responses remain rare. One way to …

nl (code pays fourni par la source)