Pleun A.M. Engbers

Live-cell imaging 53BP1 foci

Pleun A.M. Engbers, Tijmen H. de Wolf, Guillermo Garrido-Hernandez, Stefan van Alen et autres

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Live-cell imaging 53BP1 foci

Pleun A.M. Engbers, Tijmen H. de Wolf, Guillermo Garrido-Hernandez, Stefan van Alen et autres

nl (code pays fourni par la source)

LiFT: Live foci tracking for quantitative analysis of DNA damage dynamics

Tijmen H. de Wolf, Pleun A.M. Engbers, Justine Perrin, Krijn H. van der Steen et autres

ABSTRACT Quantitative analysis of radiation induced DNA double strand breaks (DSBs) and their repair is essential for understanding and eventually contributing to improving radiation-based cancer therapies. Using live-cell microscopy, the formation and resolution of DSBs over time can be followed in individual …

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SSTR2 receptor states and cellular metabolism modulate 177Lu-DOTATATE binding affinity

Sara Lundsten, Pleun A.M. Engbers, Julie Nonnekens, Sina Bondza

G protein-coupled receptors (GPCRs) are the target for approximately 36% of approved drugs and control many cell signaling pathways. Among these is the somatostatin receptor 2 (SSTR2), which can be targeted by the radiolabeled somatostatin analog [ 177 Lu]Lu-DOTA-Tyr 3 -octreotate ( …

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Cellular responses to targeted radionuclide therapy: rethinking radiobiology under continuous low dose rates

Pleun A.M. Engbers, Julie Nonnekens, Mariangela Sabatella

Targeted radionuclide therapy (TRT) delivers ionizing radiation directly to cancer cells through radio molecules that bind tumor-associated targets. Clinically successful examples include somatostatin receptor-directed TRT for neuroendocrine tumors, and prostate specific membrane antigen-targeted TRT for prostate cancer. Despite these advances, therapeutic efficacy …

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SSTR2 Receptor States and Cellular Metabolism Modulate 177Lu-DOTATATE binding affinity

Sara Lundsten Salomonsson, Pleun A.M. Engbers, Julie Nonnekens, Sina Bondza

G protein coupled receptors (GPCRs) are the target for approximately 36% of approved drugs and control many cell signaling pathways. Among these is the somatostatin receptor 2 (SSTR2), which can be targeted by the radiolabeled somatostatin analog [ 177 Lu]Lu-DOTA-Tyr 3 -octreotate …

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Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

BACKGROUND: ]octreotate has been established as treatment for patients with metastatic neuroendocrine tumors (NETs) that overexpress the somatostatin receptor (SSTR). While PRRT improves survival and quality of life, curative responses remain rare. One way to enhance PRRT efficacy is to combine it …

nl (code pays fourni par la source)

Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

nl (code pays fourni par la source)

Additional file 1 of Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Supplementary Material 1.

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Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Abstract Background Peptide receptor radionuclide therapy (PRRT) employing [177Lu]Lu-[DOTA-Tyr3]octreotate has been established as treatment for patients with metastatic neuroendocrine tumors (NETs) that overexpress the somatostatin receptor (SSTR). While PRRT improves survival and quality of life, curative responses remain rare. One way to …

nl (code pays fourni par la source)

Additional file 1 of Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Supplementary Material 1.

nl (code pays fourni par la source)

Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

Pleun A.M. Engbers, Thom G. A. Reuvers, José María Heredia‐Genestar, Jiang Chang et autres

Abstract Background Peptide receptor radionuclide therapy (PRRT) employing [177Lu]Lu-[DOTA-Tyr3]octreotate has been established as treatment for patients with metastatic neuroendocrine tumors (NETs) that overexpress the somatostatin receptor (SSTR). While PRRT improves survival and quality of life, curative responses remain rare. One way to …

nl (code pays fourni par la source)