Jacinta van de Grint

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1

Alba Muniesa-Vargas, Cristina Ribeiro-Silva, Carlota Davó-Martínez, Anja Raams et autres

The XPG endonuclease is crucial for nucleotide excision repair (NER) and other genome maintenance pathways. Precise regulation of XPG recruitment and activity during DNA repair is essential to avoid erroneous DNA incisions and genomic instability. In this study, we employed live-cell imaging …

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A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Jacinta van de Grint, Mengqi Huang, Ruben Sangers, Hanny Odijk et autres

Senescence is a durable state of cell cycle arrest that can be induced by various stressors, including DNA damage caused by chemotherapeutic agents or ionizing radiation. In the context of cancer, therapy-induced senescence (TIS) plays a dual role: while it effectively halts …

nl (code pays fourni par la source)

Transcriptional stress in aging: integrating experimental data and modeling to quantify DNA damage accumulation

Jacinta van de Grint, Marko Rašeta, Renata M. C. Brandt, Yvette van Loon et autres

Accumulating DNA damage plays a crucial role in aging, particularly in post-mitotic tissues by disrupting transcription and causing transcriptional stress—a state marked by reduced transcriptional productivity. Transcriptional stress disproportionately affects long genes, due to the random distribution of DNA lesions across the …

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Mathematical Model of Cell Death as a Consequence of DNA Damage

Marko Rašeta, Jacinta van de Grint, Shannon Dealy, Jiang Chang et autres

de (code pays fourni par la source)

Mathematical model of transcription loss due to accumulated DNA damage

Marko Rašeta, Shannon Dealy, Jacinta van de Grint, Jiang Chang et autres

Abstract We offer a simple mathematical model of gene transcription loss due to accumulated DNA damage in time based on widely agreed biological axioms. Closed form formulae characterizing the distribution of the underlying stochastic processes representing the transcription loss upon specified number …

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