Yanmei Huang

N-linked glycosylation of GETV envelope proteins affect viral infection and pathogenicity

Hui Meng, Tianyi Wang, Chunxiao Mou, Yanmei Huang et autres

Getah virus (GETV) is an emerging mosquito-borne pathogen with a broad host range, posing a significant threat to livestock and public health. Although putative N-linked glycosylation sites on its envelope proteins have been reported, their precise functional roles remain uncharacterized. In this …

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S100a4 mediated peritoneal B1 lymphocytes play a critical role in host protection against helminth infection

Fei Guan, X Luo, Yanmei Huang, Jiang Chang et autres

BACKGROUND: Trichinellosis is a globally prevalent parasitic disease caused by infection of Trichinella spiralis. B1 cells are critically involved in immune defense against multiple parasitic infections, yet their functional role in trichinellosis remains uncharacterized. METHODS: Wild-type, Btk conditional knockout and S100a4 knockout …

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MDA5 regulates BCR signaling and B-cell function via NF-κB-mediated DNM1

Li Luo, Yi Wang, Guofeng Fang, Jiang Chang et autres

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AIM2 positively regulates B cell activation and function through the SNX9-PI3K-WASP axis

Yanmei Huang, Pengyue Gao, Li Luo, Yuxin Bai et autres

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Detection of Molecular Residual Disease by Circulating Tumor DNA in Early-Stage Node-Negative Rectal Cancers (CCTG CO.28) Using a Tumor-Informed Assay

Jonathan M. Loree, Emma Titmuss, Chris J. O’Callaghan, Carl J. Brown et autres

PURPOSE There is increasing interest in organ preservation for early-stage rectal cancer. Circulating tumor DNA (ctDNA) for detection of molecular residual disease may aid in clinical decision making for these approaches. METHODS The Canadian Cancer Trials Group (CCTG) CO.28 NEO trial was …

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STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1 (CX3CR1) in hyper-IgE syndrome

Ju Liu, Jingzhi Yang, Jianing Tang, Hongxia Tang et autres

Abstract Mutations in the signal transducer and activator of transcription 3 ( STAT3 ) gene are strongly associated with Hyper-IgE Syndrome (HIES), a rare immunodeficiency disorder characterized by elevated levels of IgE and recurrent infections. The molecular mechanisms of how STAT3 dysfunction …

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HMGB1 couples LEF1 to regulate B cell immunity

Qiuyue Chen, Ziyin Zhang, Nanshu Xiang, Li Luo et autres

Secreted high mobility group box protein 1 (HMGB1) regulates the adaptive immune response and acts as a biosensor for cells undergoing necrosis, stress, and inflammatory stimulation. However, its role in B cells remains enigmatic. Here, we demonstrate that HMGB1 is critical for …

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Senescent B cells regulate CD38 expression via FOXO1 in pneumonia resulting from PIK3CD (R437C) mutations

Ju Liu, Yuxin Bai, Jianing Tang, Yanmei Huang et autres

Abstract Activated phosphoinositide 3-kinase delta syndrome (APDS) is a primary immunodeficiency characterized by hyperactivated lymphocytes and recurrent infections. This study presents a 2.5-year-old patient with a novel PIK3CD gene mutation (c.1309C>T; p. R437C) derived from his mother. We explored the immunological consequences …

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B cell dysfunction in thalamus and brainstem involvement and high lactate caused by novel mutation of EARS2 gene

Yu Wen, Yanmei Huang, Wendi Zhang, Ping Chen et autres

PURPOSE: The EARS2 gene, a member of the mt-aaRS family, encodes mitochondrial glutamyl-tRNA synthetase (GluRS), which is involved in the synthesis of mitochondrial proteins. Pathogenic defects in EARS2 may cause mitochondrial OXPHOS deficiency, which is associated with a rare autosomal-recessive mitochondrial disease, …

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B cell dysfunction in thalamus and brainstem involvement and high lactate caused by novel mutation of EARS2 gene

Yu Wen, Yanmei Huang, Wendi Zhang, Ping Chen et autres

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DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells

Heng Gu, Miaomiao Xie, Siyu Zhao, Xudong Luo et autres

DOCK8 deficiency has been shown to affect the migration, function, and survival of immune cells in innate and adaptive immune responses. The immunological mechanisms underlying autosomal recessive (AR) hyper-IgE syndrome (AR-HIES) caused by DOCK8 mutations remain unclear, leading to a lack of …

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Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4+ T cells

Panpan Jiang, Siyu Zhao, Xiaoyu Li, Shiyan Hu et autres

Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a primary immunodeficiency disease caused by mutations in exon 45 of the DOCK8 gene. The clinical signs primarily consist of increased serum IgE levels, eczema, repeated skin infections, allergies, and upper respiratory tract infections. …

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