Meihua Bao

Environmental toxicant exposure and diabetes risk: An exposome-wide association study integrating mixture effects and molecular mechanisms

Qing-Shuang Yang, Jia-Qi Xu, Ruiling Liu, Jiao Zheng et autres

Environmental toxicant exposure has emerged as a potential contributor to diabetes, yet systematic investigations integrating multiple chemicals and biological mechanisms remain limited. This study employed a hypothesis-generating, exposome-toxicogenomic framework to examine the associations between diverse environmental toxicants and diabetes risk and to …

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Investigating the association between systemic immune-inflammation index and female fertility: a retrospective cohort study

Qi Yao, Ruiling Liu, Yiyan Zeng, Xing-Yu Lv et autres

BACKGROUND: Inflammation has been linked to female fertility, yet its impact on ovarian reserve and response remains unclear. This study investigates the associations between systemic inflammatory markers, ovarian reserve—assessed by anti-Müllerian hormone (AMH) and antral follicle count (AFC)—and ovarian response, measured by …

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Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits

Bin Zeng, Shuling Xu, Dongqi Zhou, Rumeng Chen et autres

Intervertebral disc degeneration (IVDD) is a main contributor to low back pain, often considered a chronic condition. This highlights the importance of early identification of potential risk factors and implementation of preventive measures. Therefore, comprehending the causal factors underlying IVDD is crucial. …

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Interpretable machine learning model for predicting MII oocyte retrieved following controlled ovarian stimulation: a retrospective cohort study of 24,976 IVF/ICSI cycles

Lu Zhang, Lijuan Fu, Yu‐Ling Hu, Hao Yu et autres

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Apelin-13-Mediated Upregulation of METTL3 Ameliorates Alzheimer’s Disease via Inhibiting Neuroinflammation Through m6A-Dependent Regulation of lncRNA BDNF-AS

Li Han, Rong Wang, Yiran Liu, Yi Zhong et autres

Apelin-13, a neuropeptide, has been recognized for its neuroprotective properties. Our previous study found apelin-13 improves cognitive function in Alzheimer's disease (AD) rats by inhibiting neuroinflammation through upregulation of BDNF/TrkB signaling pathway. However, the precise mechanism by which apelin-13 modulates BDNF remains …

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Association of HPT axis hormones with metabolic comorbidities among individuals with and without anxiety: A population-based study

Rumeng Chen, Zhiwei Zheng, Menghua Liu, Yining Ding et autres

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Unraveling the influence of body mass index on complex diseases in East Asians: Insights from Mendelian randomization phenome-wide association study

Ben Wu, Weixin Li, Shuling Xu, Rumeng Chen et autres

Studies on the relationship between body mass index (BMI) and different disease phenotypes have either not included systematic causal inference or have mostly focused on European populations. This highlights the importance of conducting Mendelian randomization (MR) phenome-wide association study to explore the …

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Effects of Astaxanthin Supplement on Cardiovascular Health: A Systematic Review and Meta-Analysis

Yongjie Liu, Wing Yin Mo, H Ye, Meihua Bao et autres

Background: The objective of this study was to evaluate the effects of astaxanthin intake on the cardiovascular disease-related indicators. Materials and Methods: Fives databases, including PUBMED, CNKI, WEIPU, WAN FANG and Clinical Trials were searched up to June 30, 2023. The random-effects …

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Efficacy and safety of Shenfu injection on bradyarrhythmia: A systematic review and meta-analysis

Yongfang Wei, Meihui Yan, Rumeng Chen, Yining Ding et autres

BACKGROUND: Bradyarrhythmia is a form of arrhythmia commonly seen in clinical settings. This study aims to investigate the efficacy and safety of the Shenfu injection (SFI) in the treatment of bradyarrhythmia. METHODS: A comprehensive search was conducted in seven databases for randomized …

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Impact of Endometrial Polyps on Pregnancy Outcomes in Patients with Endometriosis and Infertility: A Systematic Review and Meta-analysis.

Liang Zhang, Qian Han, Meihua Bao, Ying Wu

Objective: To evaluate the impact of endometrial polyps (EP) on postoperative pregnancy outcomes in infertile women with endometriosis (EMs). Methods: PubMed, Embase, The Cochrane Library, CNKI, VIP, SinoMed, and WanFang Data databases were searched to include clinical studies on the effect of …

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Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations

Li Han, Shuling Xu, Rumeng Chen, Zhiwei Zheng et autres

Most analyses of hemoglobin A1c (HbA1c) and multiple common diseases have focused on European populations, thus there is a need for Mendelian randomization phenome-wide association study (MR-PheWAS) in East Asian populations. We used MR-PheWAS to investigate the potential causal associations between HbA1c …

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Causal associations of self-reported walking pace with respiratory diseases: A Mendelian randomization analysis

Chunxia Huang, Yining Ding, Shuling Xu, Rumeng Chen et autres

Although studies have indicated causality between brisk walking and various diseases, the relationships between walking pace and respiratory diseases lack thorough investigation. The underlying relationships between walking pace and various respiratory diseases were examined through univariable Mendelian randomization (MR) analyses. Furthermore, we …

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