Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations
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Le résumé fourni par la source
Most analyses of hemoglobin A1c (HbA1c) and multiple common diseases have focused on European populations, thus there is a need for Mendelian randomization phenome-wide association study (MR-PheWAS) in East Asian populations. We used MR-PheWAS to investigate the potential causal associations between HbA1c and 159 types of diseases in the Biobank Japan dataset, employing the inverse variance weighted as the primary statistical approach, supplemented by MR-Egger and weighted median analyses. Additionally, multiple sensitivity analyses were conducted to assess heterogeneity and pleiotropy. High HbA1c levels are associated with an increased risk of type 1 diabetes (odds ratio [OR] = 4.07; 95% confidence interval [CI]: 2.34~7.07), type 2 diabetes (OR = 4.76; 95% CI: 3.01~7.55), cataract (OR = 1.33; 95% CI: 1.18~1.51), diabetic nephropathy (OR = 5.70; 95% CI: 2.24~14.46), and peripheral arterial disease (OR = 1.62; 95% CI: 1.29~2.04). Conversely, elevated HbA1c levels are associated with a reduced risk of asthma (OR = 0.76; 95% CI: 0.67~0.86), breast cancer (OR = 0.75; 95% CI: 0.65~0.87), and cerebral aneurysm (OR = 0.71; 95% CI: 0.57~0.88). The results of the causal association between HbA1c and numerous diseases in East Asian populations provides insights for the region's specialized glycemic control and disease prevention programs, as well as new preventive and treatment options.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations
- Date Crossref
- 14/03/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Changsha Medical University The Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics pays non établi dans la noticeUniversité ou école supérieure
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Beijing University of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmaceutical Science Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations pays non établi dans la noticeUniversité ou école supérieure
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104:11(e41861) pays non établi dans la noticeInstitution
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Bao M. Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations. Medicine 2025 He B pays non établi dans la noticeOrganisation à but non lucratif
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School of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
The Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics — Changsha Medical University, Beijing University of Chinese Medicine et Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations — School of Pharmaceutical Science, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.