Rumeng Chen

Evaluating potential risk factors linked to endometriosis

Zhiwei Zheng, Peipei Hong, Rumeng Chen, Li Han et autres

Earlier examinations of how risk factors relate to endometriosis (EMT) have largely depended on observational designs, which arrived at conflicting conclusions. The present approach seeks to probe the causal association between 108 traits and EMT by means of Mendelian randomization (MR) analysis. …

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Genetically predicted lower FLT3L levels increase the risk of hypertrophic cardiomyopathy partly mediated by phosphate: Evidence from a 2-step Mendelian randomization analysis

Y J Li, Rumeng Chen, Chunyan Hou, Zhiwei Zheng et autres

We performed a 2-step Mendelian randomization (MR) study to investigate the associations of Fms-related tyrosine kinase 3 ligand (FLT3L) and phosphate levels with the risk of hypertrophic cardiomyopathy (HCM). Genetic instruments for 75 circulating inflammatory factors were obtained from the NHGRI-EBI GWAS …

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Extracellular Vesicle-Based Strategies for the Prevention of Chemotherapy-Induced Cardiotoxicity

Shen Zhaoqin, Jie Qiu, Wei Yu, Rumeng Chen et autres

Chemotherapy-induced cardiotoxicity (CIC) is a major limitation of modern anticancer therapy, particularly with anthracyclines and targeted agents, and contributes to long-term cardiovascular complications in cancer survivors. Extracellular vesicles (EVs) are nanoscale lipid-bilayer particles that mediate intercellular communication through the transfer of proteins, …

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Causal effect of urinary sodium-to-creatinine ratio on gastrointestinal diseases: A two-sample Mendelian randomization study

Yan Jiang, Zhang Zhang, Yining Ding, Shuling Xu et autres

Given the epidemiological evidence suggesting an association between sodium intake and various gastrointestinal (GI) disorders, this study aimed to investigate the causal effect of genetically predicted urinary sodium-to-creatinine ratio (UNaUCr), a proxy for sodium intake, on GI diseases. Employing a Mendelian Randomization …

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Impact of a Nationwide Atrial Fibrillation Center Program on Anticoagulation Care and Clinical Outcomes in China: A Longitudinal Study

Lu Jia, Rumeng Chen, Qiqi Cao, Jinglin Wang et autres

Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits

Bin Zeng, Shuling Xu, Dongqi Zhou, Rumeng Chen et autres

Intervertebral disc degeneration (IVDD) is a main contributor to low back pain, often considered a chronic condition. This highlights the importance of early identification of potential risk factors and implementation of preventive measures. Therefore, comprehending the causal factors underlying IVDD is crucial. …

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Association of HPT axis hormones with metabolic comorbidities among individuals with and without anxiety: A population-based study

Rumeng Chen, Zhiwei Zheng, Menghua Liu, Yining Ding et autres

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Unraveling the influence of body mass index on complex diseases in East Asians: Insights from Mendelian randomization phenome-wide association study

Ben Wu, Weixin Li, Shuling Xu, Rumeng Chen et autres

Studies on the relationship between body mass index (BMI) and different disease phenotypes have either not included systematic causal inference or have mostly focused on European populations. This highlights the importance of conducting Mendelian randomization (MR) phenome-wide association study to explore the …

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Identification of novel therapeutic targets for atrial fibrillation through Mendelian randomization analysis of druggable genes

Yining Ding, Rumeng Chen, Zhiwei Zheng, Shuling Xu et autres

BACKGROUND: Innovative therapeutic approaches are essential for treating atrial fibrillation (AF), yet genetic support for AF-specific drug targets remains limited. METHODS: This Mendelian randomization (MR) study employed cis-expression quantitative trait loci (cis-eQTLs) to assess the causal relationships between gene expression and AF. …

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Efficacy and safety of Shenfu injection on bradyarrhythmia: A systematic review and meta-analysis

Yongfang Wei, Meihui Yan, Rumeng Chen, Yining Ding et autres

BACKGROUND: Bradyarrhythmia is a form of arrhythmia commonly seen in clinical settings. This study aims to investigate the efficacy and safety of the Shenfu injection (SFI) in the treatment of bradyarrhythmia. METHODS: A comprehensive search was conducted in seven databases for randomized …

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Identification of Novel Therapeutic Targets for Hypertension

Zhiwei Zheng, Rumeng Chen, Menghua Liu, Yining Ding et autres

BACKGROUND: Persistently high blood pressure remains the leading risk factor for mortality worldwide. This study aims to identify potential drug targets for hypertension. METHODS: Mendelian randomization was used to identify therapeutic targets for hypertension. Genome-wide association study summary statistics were obtained from …

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Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations

Li Han, Shuling Xu, Rumeng Chen, Zhiwei Zheng et autres

Most analyses of hemoglobin A1c (HbA1c) and multiple common diseases have focused on European populations, thus there is a need for Mendelian randomization phenome-wide association study (MR-PheWAS) in East Asian populations. We used MR-PheWAS to investigate the potential causal associations between HbA1c …

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