Zhiwei Zheng

Evaluating potential risk factors linked to endometriosis

Zhiwei Zheng, Peipei Hong, Rumeng Chen, Li Han et autres

Earlier examinations of how risk factors relate to endometriosis (EMT) have largely depended on observational designs, which arrived at conflicting conclusions. The present approach seeks to probe the causal association between 108 traits and EMT by means of Mendelian randomization (MR) analysis. …

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Genetically predicted lower FLT3L levels increase the risk of hypertrophic cardiomyopathy partly mediated by phosphate: Evidence from a 2-step Mendelian randomization analysis

Y J Li, Rumeng Chen, Chunyan Hou, Zhiwei Zheng et autres

We performed a 2-step Mendelian randomization (MR) study to investigate the associations of Fms-related tyrosine kinase 3 ligand (FLT3L) and phosphate levels with the risk of hypertrophic cardiomyopathy (HCM). Genetic instruments for 75 circulating inflammatory factors were obtained from the NHGRI-EBI GWAS …

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C-reactive protein-to-lymphocyte ratio and stroke: associations with prevalence and subsequent mortality in NHANES 1999–2010

Yan Miao, Jianxin Chen, Zhiwei Zheng, Yu Zhang et autres

Early risk detection is critical for timely intervention to reduce stroke morbidity and recurrence rate. This study systematically investigated the association between the CRP-to-lymphocyte ratio (CLR) and stroke prevalence, aiming to evaluate whether CLR may serve as a convenient and readily accessible …

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Causal effect of urinary sodium-to-creatinine ratio on gastrointestinal diseases: A two-sample Mendelian randomization study

Yan Jiang, Zhang Zhang, Yining Ding, Shuling Xu et autres

Given the epidemiological evidence suggesting an association between sodium intake and various gastrointestinal (GI) disorders, this study aimed to investigate the causal effect of genetically predicted urinary sodium-to-creatinine ratio (UNaUCr), a proxy for sodium intake, on GI diseases. Employing a Mendelian Randomization …

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The Nonlinear Relationship Between Serum Uric Acid and Cardiovascular Disease Risk: Mechanistic Insights and Clinical Implications

Chunyan Hou, Zhiwei Zheng, Xiaoqian Zheng, Menghua Liu et autres

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RF-Based 3D SLAM Rivaling Vision Approaches

Haowen Lai, Zhiwei Zheng, M. Zhao

This paper presents CartoRadar, a novel RF-based SLAM system that delivers high-fidelity 3D mapping with centimeter-level accuracy. CartoRadar builds on top of the advancements in learning-based RF imaging. However, learning-based systems often exhibit variation in prediction accuracy during inference. To address this …

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Two-Layered Reward Reinforcement Learning in Humanoid Robot Motion Tracking

Jiahong Xu, Zhiwei Zheng, Fangyuan Ren

In reinforcement learning (RL), reward function design is critical to the learning efficiency and final performance of agents. However, in complex tasks such as humanoid motion tracking, traditional static weighted reward functions struggle to adapt to shifting learning priorities across training stages, …

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Association of HPT axis hormones with metabolic comorbidities among individuals with and without anxiety: A population-based study

Rumeng Chen, Zhiwei Zheng, Menghua Liu, Yining Ding et autres

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Identification of novel therapeutic targets for atrial fibrillation through Mendelian randomization analysis of druggable genes

Yining Ding, Rumeng Chen, Zhiwei Zheng, Shuling Xu et autres

BACKGROUND: Innovative therapeutic approaches are essential for treating atrial fibrillation (AF), yet genetic support for AF-specific drug targets remains limited. METHODS: This Mendelian randomization (MR) study employed cis-expression quantitative trait loci (cis-eQTLs) to assess the causal relationships between gene expression and AF. …

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Identification of Novel Therapeutic Targets for Hypertension

Zhiwei Zheng, Rumeng Chen, Menghua Liu, Yining Ding et autres

BACKGROUND: Persistently high blood pressure remains the leading risk factor for mortality worldwide. This study aims to identify potential drug targets for hypertension. METHODS: Mendelian randomization was used to identify therapeutic targets for hypertension. Genome-wide association study summary statistics were obtained from …

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Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations

Li Han, Shuling Xu, Rumeng Chen, Zhiwei Zheng et autres

Most analyses of hemoglobin A1c (HbA1c) and multiple common diseases have focused on European populations, thus there is a need for Mendelian randomization phenome-wide association study (MR-PheWAS) in East Asian populations. We used MR-PheWAS to investigate the potential causal associations between HbA1c …

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Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives

Menghua Liu, Rumeng Chen, Zhiwei Zheng, Shuling Xu et autres

Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular and cellular mechanisms within the inflammatory microenvironment of atherosclerosis, hypertension and diabetic cardiomyopathy. …

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