Sarah T. Diepstraten

A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts, Amy Heidersbach et autres

CRISPR activation (CRISPRa) enables precise up-regulation of gene expression for ex vivo and in vivo applications. However, a lack of scalable, high-coverage tools has limited comprehensive genetic screening in murine models. Here, we introduce Partita, a next-generation mouse whole-genome CRISPRa sgRNA platform, …

au, cn (code pays fourni par la source)

γδ T cells modulate anti-tumor immunity in small cell lung cancer

Jin Ng, Yue You, Tina Z. Zhang, Jonas B. Hess et autres

Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, which is likely caused by the epigenetic silencing of MHC-I. Elucidating MHC-I-independent immune recognition mechanisms is therefore crucial for enhancing treatment responses and improving clinical outcomes …

au, de, us, gb (code pays fourni par la source)

Abstract SY35-01: Enhancing BH3 mimetic drug induced killing of malignant cells for cancer therapy

Sarah T. Diepstraten, John E. La Marca, Yin Yuan, Fiona C. Brown et autres

Abstract BH3 mimetic drugs are showing great success in the clinic, particularly in hematological cancers. However, p53-mutant hematological cancers remain a major clinical challenge and BH3 mimetic drugs have not shown marked single-agent effects in solid cancers. BH3-mimetic drugs inhibit BCL-2 pro-survival …

au (code pays fourni par la source)

What is a ‘cancer gene’? How genetic mutations lead to cancer

Sarah T. Diepstraten, John Marca

au (code pays fourni par la source)

Can blood tests really detect cancer?

John Marca, Sarah T. Diepstraten, Cameron Lewis

au (code pays fourni par la source)

3151 – PUTTING THE STING BACK INTO THERAPY FOR P53 MUTANT BLOOD CANCERS

Sarah T. Diepstraten, John E. La Marca, Yin Yuan, Savannah Young et autres

au (code pays fourni par la source)

3107 – ADVANCED CRISPR KNOCKOUT AND ACTIVATION MOUSE MODELS AS TOOLS FOR INVESTIGATING HEMATOLOGY AND HEMATOLOGICAL MALIGNANCIES

John E. La Marca, Sarah T. Diepstraten, Wei Jin, Yexuan Deng et autres

au (code pays fourni par la source)

Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

Margaret A. Potts, Shinsuke Mizutani, Yexuan Deng, Srimayee Vaidyanathan et autres

Identifying tumor suppressor genes is predicted to inform on the development of novel strategies for cancer therapy. To identify new lymphoma driving processes that cooperate with oncogenic MYC, which is abnormally highly expressed in ~70% of human cancers, we use a genome-wide …

au, jp, cn, sg, us (code pays fourni par la source)

MNT: a new target for AML

Karla C. Fischer, Véronique Litalien, Sarah T. Diepstraten, Michelle Jahja et autres

Deregulated expression of the transcription factor c-MYC is well-established as a primary driver of diverse tumour types. Here, for the first time, we show that mouse and human myeloid leukaemias provoked by oncogenic MLL (mixed lineage leukaemia) fusion proteins are dependent on …

au (code pays fourni par la source)

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts, Amy J. Heidersbach et autres

Abstract CRISPR activation (CRISPRa) enables precise, locus-specific upregulation of gene expression, offering potential for both ex vivo and in vivo applications. However, the lack of scalable, high-coverage tools has limited its use in comprehensive genetic screens, particularly in murine models. Here, we …

au, cn, ca (code pays fourni par la source)

Are chemicals to blame for cancer in young people? Here’s what the evidence says

Sarah T. Diepstraten, John E. La Marca

au (code pays fourni par la source)

What is mantle cell lymphoma? Magda Szubanski’s ‘rare and fast-moving’ cancer, explained

John E. La Marca, Sarah T. Diepstraten

au (code pays fourni par la source)