Katharina Mauel

Canonical Notch2 signaling regulates development and maintenance of iron-recycling macrophages and iron homeostasis

Frauline Nicole Schroth, Tamar Kapanadze, Stefan Sablotny, Yuangao Xu et autres

Abstract Red pulp macrophages (RPM) and bone marrow macrophages (BMM) are iron-recycling cells, involved in iron homeostasis and erythropoiesis. Here we show, by conditional deletion strategies using Cx3cr1Cre-mediated targeting to inactivate Notch signalling components in mice, that canonical Notch2 signalling regulates the …

CD163+ red pulp macrophages interact with marginal metallophilic macrophages during blood-stage malaria to maintain splenic architecture

Katharina Mauel, DORIS J. HIRSCHMANN, Nelli Blank-Stein, Marie-Louise Diefenbach-Wilke et autres

The spleen harbors distinct macrophage subsets that support circulatory homeostasis and initiate immune responses, but the ontogeny and long-term dynamics of these populations remain incompletely understood. Here, we identified a transcriptionally and developmentally distinct CD163-expressing red pulp macrophage (CD163 high RPM) population …

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Kupffer cell programming by maternal obesity triggers fatty liver disease

Hao Huang, Nora Reka Balzer, Lea Seep, Iva Šplíchalová et autres

Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis1. Upon liver colonization, KCs rapidly acquire a tissue-specific transcriptional signature, mature alongside the developing liver and adapt to its functions1–3. Throughout development and adulthood, KCs perform distinct core functions …

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Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism

Nikola Makdissi, Maria Francesca Viola, Lisa M Steinheuer, Nelli Blank‐Stein et autres

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CD163 Expression Defines a Red Pulp Macrophage Subset Engaged in Crosstalk with Marginal Metallophilic Macrophages During Blood-Stage Malaria

Katharina Mauel, DORIS J. HIRSCHMANN, Nelli Blank, Marie-Louise Diefenbach-Wilke et autres

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Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

Amir Hossein Kayvanjoo, Iva Šplíchalová, David Alejandro Bejarano, Hao Huang et autres

During embryogenesis, the fetal liver becomes the main hematopoietic organ, where stem and progenitor cells as well as immature and mature immune cells form an intricate cellular network. Hematopoietic stem cells (HSCs) reside in a specialized niche, which is essential for their …

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Author response: Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

Amir Hossein Kayvanjoo, Iva Šplíchalová, David Alejandro Bejarano, Hao Huang et autres

Identification of distinct yolk sac-derived macrophage subpopulations in the fetal liver reveals their crucial role in shaping the hematopoietic niche, impacting erythropoiesis and granulopoiesis through direct interactions with long-term hematopoietic stem cells.

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Fate-Mapping of Hematopoietic Stem Cell-Derived Macrophages

Katharina Mauel, Elvira Mass

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Developmental programming of Kupffer cells by maternal obesity causes fatty liver disease in the offspring

Hao Huang, Iva Šplíchalová, Nora Reka Balzer, Lea Seep et autres

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Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

Amir Hossein Kayvanjoo, Iva Šplíchalová, David Alejandro Bejarano, Hao Huang et autres

Abstract During embryogenesis, the fetal liver becomes the main hematopoietic organ, where stem and progenitor cells as well as immature and mature immune cells form an intricate cellular network. Hematopoietic stem cells (HSCs) reside in a specialized niche, which is essential for …

de, us (code pays fourni par la source)

Mesenchymal Stem Cells Augment the Anti-Bacterial Activity of Neutrophil Granulocytes

Sven Brandau, Mark Jakob, Kirsten Bruderek, Friedrich Bootz et autres

BACKGROUND: Mesenchymal stem cells (MSCs) participate in the regulation of inflammation and innate immunity, for example by responding to pathogen-derived signals and by regulating the function of innate immune cells. MSCs from the bone-marrow and peripheral tissues share common basic cell-biological functions. …

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Interaction with Mesenchymal Stem Cells Provokes Natural Killer Cells for Enhanced IL-12/IL-18-Induced Interferon-Gamma Secretion

H. Hampton Thomas, Markus Jäger, Katharina Mauel, Sven Brandau et autres

Tissue injury induces an inflammatory response accompanied by the recruitment of immune cells and of mesenchymal stem cells (MSC) that contribute to tissue regeneration. After stimulation with interleukin- (IL-) 12 and IL-18 natural killer (NK) cells secrete the proinflammatory cytokine interferon- (IFN-) …

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