David Alejandro Bejarano

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response

Xinyuan Liu, Filiz Demircik, M. V. Antipova, Emmanouil Stylianakis et autres

Abstract Natural killer and CD8 + T cells are critical in the elimination of blood-borne viruses such as cytomegalovirus (CMV); however, the role of B cells in this process is less clear. Here, using a murine CMV (MCMV) infection model, we demonstrated …

de, cn, nl, ca (code pays fourni par la source)

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

Frederike Westermann, Selma Tuzlak, Victor Linus Kreiner, Aline Ignacio et autres

Granulocyte-macrophage colony-stimulating factor (GM-CSF, Csf2) is a potent proinflammatory cytokine. At steady state, however, GM-CSF has a distinct homeostatic function, being essential for the differentiation and maintenance of alveolar macrophages. Whether macrophage development in nonpulmonary tissues is similarly dependent on GM-CSF is …

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

Frederike Westermann, Selma Tuzlak, Victor Kreiner, Aline Ignacio et autres

ch, ca, de, cn, fr, gb (code pays fourni par la source)

An islet-resident macrophage antioxidant program preserves β cell physiology

Amélie Grosjean, Aude Jalon, Claire Leveau, Marc Diedisheim et autres

Pancreatic islet-resident macrophages (IRMs) display an activated phenotype and contribute to islet development and remodeling, yet their origin, heterogeneity, and functional roles remain poorly understood. Using complementary fate-mapping systems, we show that, in adult mice, around half of IRMs originate from circulating …

fr, de, cn, be (code pays fourni par la source)

Septal LYVE1 + macrophages control adipocyte stem cell adipogenic potential

Xiaotong Yu, Hwee Ying Lim, Ziyi Li, Diego Adhemar Jaitin et autres

Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct localization, turnover, and phenotypes. Septal adipose tissue macrophages (sATMs), marked by CD209b and lymphatic vessel endothelial …

cn, sg, il, fr, de, jp (code pays fourni par la source)

GM-CSF derived from alveolar type 2 cells promotes CD301b + cDC2 generation and allergic airway inflammation

Julia Gschwend, Antonie Lechner, Nikolaos D. Sidiropoulos, Paul Maier et autres

Pulmonary conventional dendritic cells (cDCs) are functionally and phenotypically heterogeneous antigen-presenting cells essential for orchestrating adaptive immune responses in the lung. Here, we define a cell-intrinsic role for granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling in the development of a CD301b + subset of …

ch, de, us (code pays fourni par la source)

GM-CSF derived from alveolar type 2 cells promotes CD301b$^{+}$ cDC2 generation and allergic airway inflammation

Julia Gschwend, Antonie Lechner, Nikolaos D. Sidiropoulos, Paul Maier et autres

Pulmonary conventional dendritic cells (cDCs) are functionally and phenotypically heterogeneous antigen-presenting cells essential for orchestrating adaptive immune responses in the lung. Here, we define a cell-intrinsic role for granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling in the development of a CD301b$^{+}$ subset of terminally …

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8 + T cell response

Filiz Demircik, M. V. Antipova, Emmanouil Stylianakis, Matthias Klein et autres

Abstract Natural killer and CD8 + T cells are critical in the elimination of blood-borne viruses such as cytomegalovirus (CMV); however, the role of B cells in this process is less clear. Here, using the murine CMV (MCMV) infection model, we demonstrated …

de, nl, ca (code pays fourni par la source)

Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes

Domien Vanneste, David Alejandro Bejarano, Joan Abinet, Margot Meunier et autres

Lung interstitial macrophages (IMs) are monocyte-derived parenchymal macrophages whose tissue-supportive functions remain unclear. Despite progress in understanding lung IM diversity and transcriptional regulation, the signals driving their development from monocytes and their functional specification remain unknown. Here, we found that lung endothelial …

be, de, fr (code pays fourni par la source)

Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism

Nikola Makdissi, Maria Francesca Viola, Lisa M Steinheuer, Nelli Blank‐Stein et autres

de, at (code pays fourni par la source)

Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

Frederike Westermann, Selma Tuzlak, Victor Kreiner, David Alejandro Bejarano et autres

Summary Granulocyte-macrophage colony-stimulating factor (GM-CSF) has a non-redundant role in the emergence and maintenance of alveolar macrophages (AMs). However, its role in developmental and steady-state myelopoiesis outside the lung is largely unexplored. Scanning through developing tissues using a Fate-map and reporter of …

ch, cz, de, us, cn, ca, gb, fr (code pays fourni par la source)

Amplification of autoimmune organ damage by NKp46-activated ILC1s

Stylianos-Iason Biniaris-Georgallis, Tom; https://orcid.org/0000-0002-2101-6146 Aschman, Katerina Stergioula, Frauke Schreiber et autres