Shumei Zhao

Body mass index modifies the major adverse cardiovascular and cerebral events risk of NT-proBNP in patients with acute coronary syndrome

Xizi He, Xiaojing Fang, Jiali Wang, Shumei Zhao et autres

Little is known about the relationship between body mass index (BMI) and the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute coronary syndrome (ACS). This study aimed to investigate how BMI modifies the association between NT-proBNP levels and …

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Enhancing Pseudomonas syringae pv. Actinidiae sensitivity in kiwifruit by repressing the NBS-LRR genes through miRNA-215-3p and miRNA-29-3p identification

Chengyao Jiang, Xiaoying Zhang, Jiahui Rao, Shu Luo et autres

(PSA), poses a grave threat to the global kiwifruit industry. In this study, we examined the role of microRNAs (miRNAs) in kiwifruit's response to PSA. Kiwifruit seedlings subjected to PSA treatment showed significant changes in both miRNA and gene expression compared to …

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Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

Zongyong Ai, Yu Yin, Lifeng Xiang, Gaohui Shi et autres

Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscure. Using 3D-cultured human embryos, herein we report a complete cell atlas of the early post-implantation lineages and …

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Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

Zongyong Ai, Yu Yin, Lifeng Xiang, Gaohui Shi et autres

Abstract Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage developments as well as underlying mechanisms remain obscure. Using 3D-cultured human embryos, herein we report a complete cell atlas of the early post-implantation lineages …

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Hydrogel encapsulated stem cells facilitate successful repair after spinal cord injury in rats and monkeys

Tianqing Li, Pengfei Li, Hao Yuan, Yanyin chen et autres

Abstract Promoting axonal regeneration to form nascent circuits after spinal cord injury (SCI) is a considerable challenge. While cell-based transplantation is considered a top candidate for SCI therapeutics, limited anatomical structure repair and slight functional recovery have prevented translation to the clinic. …

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miR-199a-5p Relieves Obstructive Sleep Apnea Syndrome-Related Hypertension by Targeting HIF-1α

Chunyan Guo, Minghui Zhang, Wei Su, Min Xu et autres

Introduction. Obstructive sleep apnea syndrome (OSAS) is related to hypertension. Vascular remodeling is both the pathogenesis and the structural change basis of OSAS-related hypertension. Exploring miRNA functioning in OSAS-related hypertension may offer novel diagnostic and therapeutic targets for controlling hypertension-associated cardiovascular diseases. …

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BRN2 as a key gene drives the early primate telencephalon development

Xiaoqing Zhu, Yicheng Guo, Chu Chu, Dahai Liu et autres

Evolutionary mutations in primate-specific genes drove primate cortex expansion. However, whether conserved genes with previously unidentified functions also play a key role in primate brain expansion remains unknown. Here, we focus on BRN2 ( POU3F2 ), a gene encoding a neural transcription …

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Effect of Kechuanting Acupoint Sticking Therapy On Asthma Control And Serum Metabolite Characteristics In Asthma Patients Treated With Long-Term Inhaled Corticosteroid-Formoterol

Shumei Zhao, Cong Zhang, Kuan Di, Xiaoyan Gong et autres

Abstract Background: Despite the availability of inhaled corticosteroid-formoterol treatment, asthma in some patients is poorly controlled. Kechuanting acupoint sticking therapy may regulate immunological functions to improve asthma. In this study, we focused on the effect of Kechuanting acupoint sticking therapy on disease …

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A systematic review and meta-analysis of acupoint application combined with western medicine therapy in the treatment of bronchial asthma

Jun Hu, Cong Zhang, Shumei Zhao, Kaiwen Ge et autres

BACKGROUND: This study aimed to evaluate and compare the efficacy and safety of acupoint application therapy (AAT) with conventional western medicine therapy (CWMT) and CWMT in the treatment of bronchial asthma. Since there are several researches reporting AAT with CWMT for bronchial …

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The Long Terminal Repeats of ERV6 Are Activated in Pre-Implantation Embryos of Cynomolgus Monkey

Kui Duan, Chenyang Si, Shumei Zhao, Zongyong Ai et autres

Precise gene regulation is critical during embryo development. Long terminal repeat elements (LTRs) of endogenous retroviruses (ERVs) are dynamically expressed in blastocysts of mammalian embryos. However, the expression pattern of LTRs in monkey blastocyst is still unknown. By single-cell RNA-sequencing (seq) data …

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Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis

Wenshu Zhou, Marta Silva, Chun Lei Feng, Shumei Zhao et autres

Abstract Background Spinal cord injury (SCI) is a debilitating medical condition that can result in the irreversible loss of sensorimotor function. Current therapies fail to provide an effective recovery being crucial to develop more effective approaches. Mesenchymal stem cell (MSC) exosomes have …

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Reconstitution of Human Peri-Implantation Embryogenesis With Integrated Stem Cell-Based Embryo Models

Zongyong Ai, Yu Yin, Kui Duan, Lifeng Xiang et autres

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