Ryo Koyama‐Nasu

Hyodeoxycholic acid suppresses hepatic steatosis in a PPARα-dependent manner via distinct GLP-1- and iNKT cell-mediated pathways

Eunyoung Lee, Ryo Hatano, Mariko Takami, Masanori Fujimoto et autres

Hepatosteatosis is a common metabolic disorder. Bile acids influence hepatosteatosis, immune function, and incretin secretion. However, whether bile acids mediate hepatosteatosis through these immune or endocrine pathways remain unknown. Here, we identify supplementation with hyodeoxycholic acid (HDCA) in high-fat diet-fed mice increases …

jp, gb, tw (code pays fourni par la source)

Hyodeoxycholic acid suppresses hepatic steatosis in a PPARα-dependent manner via distinct GLP-1- and iNKT cell-mediated pathways.

Eunyoung Lee, Ryo Hatano, Mariko Takami, Masanori Fujimoto et autres

Distinct thymic pDC populations promote tumor immune tolerance through complementary mechanisms

Yangsong Wang, Ryo Koyama‐Nasu, Yukihiro Endo, Ichita Hasegawa et autres

Thymic central tolerance is crucial for preventing autoimmunity, but its contribution to tumor immune evasion remains poorly understood. Here, we demonstrate that plasmacytoid dendritic cells (pDCs) in the thymus have two distinct subsets, accumulating in the thymus of tumor-bearing mice, contributing to …

jp (code pays fourni par la source)

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Tsutomu Ikawa, Tomokatsu Ikawa, Ryo Yanagiya et autres

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (miR-195) transduction let …

jp, in, de (code pays fourni par la source)

Table S2 from CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes

Ryo Koyama‐Nasu, Motoko Yagi Kimura, Masahiro Kiuchi, Ami Aoki et autres

Table S2

Table S1 from CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes

Ryo Koyama‐Nasu, Motoko Yagi Kimura, Masahiro Kiuchi, Ami Aoki et autres

Table S1

Figure S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11 from CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes

Ryo Koyama‐Nasu, Motoko Yagi Kimura, Masahiro Kiuchi, Ami Aoki et autres

Figure S1, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11

Table S3 from CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes

Ryo Koyama‐Nasu, Motoko Yagi Kimura, Masahiro Kiuchi, Ami Aoki et autres

Table S3

CCL5 paradoxically regulates glomerular injury by skewing macrophage polarization

Ika Nindya Kadariswantiningsih, Issei Okunaga, Kaho Yamasaki, Maulana Antiyan Empitu et autres

Glomerular inflammation and podocyte loss are the hallmarks of chronic kidney disease (CKD) progression. Understanding how podocytes and their microenvironment regulate inflammation is critical for developing effective therapies. In this study, we identified C-C chemokine ligand 5 (CCL5) as an inflammatory mediator …

jp, id (code pays fourni par la source)

SLAMF6 regulates basal T cell receptor signaling and influences invariant natural killer T cell lineage diversity

Yukihiro Endo, Ichita Hasegawa, Akemi Igi, Atsushi Onodera et autres

Invariant natural killer T (iNKT) cells differentiate into at least three distinct subsets within the thymus, with each subset's frequency varying considerably among mouse strains; however, the molecular mechanisms involved remain unclear. We herein report that iNKT cell lineage diversity results from …

jp, us, ru (code pays fourni par la source)

Differentiation of Cytotoxic CD8+ T Cell Subsets Under Tumor Progression: Can CD69 Be a New Therapeutic Target?

Ryo Koyama‐Nasu, Yangsong Wang, Motoko Yagi Kimura

ABSTRACT Tumor‐specific CD8+ T cells play a pivotal role in anti‐tumor immunity. Here, we review the heterogeneity of CD8+ T cell subsets during tumor progression. While both acute and chronic viral infections induce distinct CD8+ T cell responses, chronic responses are also …

jp (code pays fourni par la source)

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Tomokatsu Ikawa, Ryo Yanagiya, Ryutaro Kotaki et autres

Abstract Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (miR-195) transduction …

jp, in, de (code pays fourni par la source)