Ika Nindya Kadariswantiningsih

Faktor-Faktor yang Mempengaruhi Ketidakpatuhan Minum Obat pada Pasien Multidrug-Resistant Tuberculosis (MDR-TB): Systematic Review Studi Kohort dan Kasus Kontrol

Devina Aisha Salsabila, Damba Bestari, Ika Nindya Kadariswantiningsih

Multidrug-Resistant Tuberculosis (MDR-TB) is a global health challenge because its treatment involves a long duration and severe drug-related adverse effects. Medication non-adherence is one of the major factors contributing to treatment failure and the development of further drug resistance. This study aimed …

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WCN26-4914 Dual roles of CCL5 on podocytes and macrophages in glomerular injury

Issei Okunaga, Ika Nindya Kadariswantiningsih, Maulana Antiyan Empitu, Kaho Yamasaki et autres

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Efficacy and safety of antifungal prophylaxis in surgical intensive care unit patients: A systematic review and meta‑analysis of randomized controlled trials

Ika Nindya Kadariswantiningsih, Maulana Antiyan Empitu, Edwin Danardono, Ivan Rahmatullah et autres

Invasive fungal infections (IFIs) are serious complications among surgical intensive care unit (ICU) patients, leading to substantial morbidity and mortality. Antifungal prophylaxis and pre-emptive strategies are employed to reduce the risk of such infections, although their effectiveness and safety remain subjects of …

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Metabolic adaptation without microbiome remodelling: Rethinking early host–microbiome dynamics

Ika Nindya Kadariswantiningsih, Rishab Jayanthi, Ekram Arima

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Cardiorenal safety and efficacy of angiotensin receptor‑neprilysin inhibitors in heart failure across the ejection fraction spectrum: A meta‑analysis and meta‑regression of RCTs with 28,001 patients

Derren David Christian Homenta Rampengan, Stevanus Christian Surya, Kevin Christian Tjandra, Lele Ji et autres

Angiotensin receptor-neprilysin inhibitors (ARNIs), including sacubitril/valsartan, exert blood pressure-lowering and organ-protective effects in patients with heart failure (HF). However, differences of these effects across HF phenotypes and their impact on renal outcomes remain unclear. The present systematic review aimed to evaluate the …

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CCL5 paradoxically regulates glomerular injury by skewing macrophage polarization

Ika Nindya Kadariswantiningsih, Issei Okunaga, Kaho Yamasaki, Maulana Antiyan Empitu et autres

Glomerular inflammation and podocyte loss are the hallmarks of chronic kidney disease (CKD) progression. Understanding how podocytes and their microenvironment regulate inflammation is critical for developing effective therapies. In this study, we identified C-C chemokine ligand 5 (CCL5) as an inflammatory mediator …

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Antifungal resistance: Emerging mechanisms and implications (Review)

Ika Nindya Kadariswantiningsih, Maulana Antiyan Empitu, Timotius Santosa, Yikelamu Alimu

Antifungal resistance is a growing concern in clinical medicine, driven by the increasing incidence of fungal infections and the limited arsenal of effective antifungal drugs. This resistance is achieved by intrinsic mechanisms, such as ineffective drug‑target binding, high efflux pump activity and …

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Prevalence of extrapulmonary tuberculosis in Indonesia: protocol for systematic review and meta-analysis

Ika Nindya Kadariswantiningsih, Roy Novri Ramadhan, Derren David Christian Homenta Rampengan

BACKGROUND: Extrapulmonary tuberculosis (EPTB) is a significant public health issue in Indonesia, a country with a high tuberculosis burden. EPTB accounts for 15%-20% of global TB cases, with the proportion rising in populations co-infected with HIV. In Indonesia, estimates of EPTB prevalence …

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Pharmacological strategies for targeting biofilms in otorhinolaryngologic infections and overcoming antimicrobial resistance (Review)

Maulana Antiyan Empitu, Ika Nindya Kadariswantiningsih, Nadhirah Mohd Shakri

Biofilm formation is a key factor in the persistence and recurrence of otorhinolaryngology (ORL) infections, driving antimicrobial resistance and treatment failure. Chronic conditions, such as rhinosinusitis, otitis media and tonsillitis, are linked to biofilm-producing pathogens, forming protective extracellular matrices that shield bacteria …

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Carbapenem-resistant Enterobacterales (CRE) in Indonesia: protocol for systematic review and meta-analysis

Ika Nindya Kadariswantiningsih, Maulana Antiyan Empitu, Bulat Idrisov, Derren David Christian Homenta Rampengan et autres

Background: Carbapenem-resistant Enterobacterales (CRE) pose a significant global health threat, with increasing prevalence worldwide, including in Indonesia. Despite the public health impact, comprehensive data on the burden of CRE in Indonesia remains fragmented. This protocol outlines a systematic review and meta-analysis aiming …

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Antibiotic resistance in Indonesia: A systematic review and meta‐analysis of extended‐spectrum beta‐lactamase‐producing bacteria (2008–2024)

Ika Nindya Kadariswantiningsih, Derren David Christian Homenta Rampengan, Roy Novri Ramadhan, Alina Idrisova et autres

OBJECTIVE: Extended-spectrum beta-lactamase-producing bacteria pose a significant threat to public health due to their resistance to commonly used antibiotics. This meta-analysis aims to determine the prevalence and distribution of extended-spectrum beta-lactamase-producing bacteria in Indonesia. METHODS: This systematic review and meta-analysis adhere to …

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Antifungals Combination in Pediatric Patients with Invasive Fungal Infections: A Systematic Review and Meta-Analysis

Roy Novri Ramadhan, Derren David Christian Homenta Rampengan, Felicia Angelica Gunawan, Nathanael Jonathan Tjipta et autres