Accès ouvert
2026
article
OpenAlex
Katrin Nussbaumer, Max Hübner, Raul Da Costa, Daniel Petersheim et autres
Neutrophils are the most abundant circulating leukocytes in humans and act as key effectors of innate immunity. Severe congenital neutropenia (SCN) encompasses a heterogeneous group of disorders characterized by early onset of recurrent infections. Mutations in Jagunal homolog 1 (Jagn1) cause SCN, …
de, at, us
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Accès ouvert
2024
article
OpenAlex
Francesco Balducci, Mirko Di Rosa, Regina Roller‐Wirnsberger, Gerald Wirnsberger et autres
PURPOSE: In this study, a comprehensive analysis of costs of chronic kidney disease (CKD) was performed, to understand factors associated with the economic burden of the disease in a multicentre international framework. METHODS: The impact on costs of demographics, socio-economics, clinical, and …
it, at, nl, es, pl, il, de, se
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Accès ouvert
2023
article
OpenAlex
Yu Onodera, Jady Liang, Yuchong Li, Bryan D. Griffin et autres
Despite similar infection rates, COVID-19 has resulted in more deaths in men than women. To understand the underlying mechanisms behind this sex-biased difference in disease severity, we infected K18-human angiotensin converting enzyme 2 (ACE2) mice of both sexes with SARS-CoV-2. Our study …
jp, ca, cn, mo, il, us, at
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Accès ouvert
2023
erratum
OpenAlex
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger et autres
The original version of this Article incorrectly used nm length unit to describe the opening of SARS-CoV-2 RBD during interaction with ACE2 receptor. Instead of nm, the length distance should be described using Angstroms (Å). This has now been corrected in both …
at, de, pl, be, se, ca
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Accès ouvert
2022
article
OpenAlex
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger et autres
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby forming up to three tight bonds through its RBDs with ACE2 expressed on …
at, de, pl, be, se, ca
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Accès ouvert
2022
dataset
OpenAlex
Rong Zhou, Daniel Canena, Mateusz Sikora, Miriam Klausberger et autres
Models of SARS-CoV-2 virus spike protein bound to 1-3 of ACE2 receptors embedded in lipid nanodisks. Systems include all files in GROMACS format needed to reproduce simulations performed in the "Force-tuned Avidity of Spike Variant-ACE2 Interactions viewed on the Single-Molecule Level" article. …
at, de, se
(code pays fourni par la source)
Accès ouvert
2022
dataset
OpenAlex
Rong Zhou, Daniel Canena, Mateusz Sikora, Miriam Klausberger et autres
Models of SARS-CoV-2 virus spike protein bound to 1-3 of ACE2 receptors embedded in lipid nanodisks. Systems include all files in GROMACS format needed to reproduce simulations performed in the "Force-tuned Avidity of Spike Variant-ACE2 Interactions viewed on the Single-Molecule Level" article. …
at, de, se
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Christopher W. Fell, Astrid Hagelkrüys, Ana Cicvaric, Marion Horrer et autres
Whole‐exome sequencing of two patients with idiopathic complex neurodevelopmental disorder (NDD) identified biallelic variants of unknown significance within FIBCD1, encoding an endocytic acetyl group‐binding transmembrane receptor with no known function in the central nervous system. We found that FIBCD1 preferentially binds and …
at, us, ru, es, cn, dk, ca
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Accès ouvert
2022
article
OpenAlex
Robert H. Shoemaker, Reynold A. Panettieri, Steven K. Libutti, Howard S. Höchster et autres
As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection in the lung, and mitigate lung damage caused by deregulated signaling in …
us, at, ca
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Accès ouvert
2022
article
OpenAlex
Vanessa Monteil, Brett Eaton, Elena Postnikova, Michael Murphy et autres
The recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is, therefore, paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. Here, we report …
se, us, at, gb, es, ca
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Accès ouvert
2022
article
OpenAlex
Riem Gawish, Philipp Starkl, Lisabeth Pimenov, Anastasiya Hladik et autres
Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16, a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modeling revealed how only three Spike mutations of maVie16 enhanced interaction …
at, us, es, se, nl, ca
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Accès ouvert
2021
preprint
OpenAlex
Vanessa Monteil, Stéphanie Devignot, Jonas Klingström, Charlotte Thålin et autres
Abstract The recent emergence of the SARS-CoV-2 variant Omicron has caused considerable concern due to reduced vaccine efficacy and escape from neutralizing antibody therapeutics. Omicron is spreading rapidly around the globe and is suspected to account for most new COVID-19 cases in …
se, at, es, ca
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