Accès ouvert
2026
article
OpenAlex
Katrin Nussbaumer, Max Hübner, Raul Da Costa, Daniel Petersheim et autres
Neutrophils are the most abundant circulating leukocytes in humans and act as key effectors of innate immunity. Severe congenital neutropenia (SCN) encompasses a heterogeneous group of disorders characterized by early onset of recurrent infections. Mutations in Jagunal homolog 1 (Jagn1) cause SCN, …
de, at, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Katrin Nussbaumer, Jamey D. Marth, Markus Sperandio
Neutrophils are essential components of the innate immune system, playing a critical role in responding to infections and inflammation. Their recruitment from blood circulation to affected tissues follows a well-coordinated multistep adhesion and activation cascade. Recent studies highlight the importance of posttranslational …
de, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Roland Immler, Katrin Nussbaumer, Axel Doerner, Omar El Bounkari et autres
Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase St3gal4 −/− mice. We found a marked decrease in eosinophil extravasation into CCL11-stimulated cremaster muscles and into the inflamed peritoneal …
de, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Monika Pruenster, Roland Immler, Jonas Roth, Thomas Bromberger et autres
Abstract S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during inflammation …
de, ch, sk
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Ping Shen, Sebastian Serve, Peihua Wu, Xiaohui Liu et autres
Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain. Although age and joint trauma are prominently associated with OA occurrence, the trigger and signaling pathways propagating their pathogenic aspects are ill defined. Following long-term catabolic activity and traumatic cartilage …
de, cn
(code pays fourni par la source)