Anna A. Shabalova

Selenoprotein P deletion ameliorates metabolic stress-associated anxiety-like behavior in male mice

Guzel Gafiyatullina, Anna A. Shabalova, Hisanori Goto, Hein Ko Oo et autres

CONTEXT: Diabetes-associated metabolic stress and anxiety reciprocally influence one another's onset and course. We previously linked excessive selenoprotein P (SeP, encoded by SELENOP in humans) to pathological conditions frequently observed in individuals with diabetes. OBJECTIVE: The present study aimed to clarify the …

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Increase in Comforting Behavior (Allogrooming) During Social Interaction in Male Mice Deficient for the Slp Gene of Complement Component C4

Yasuhiko Yamamoto, Anpei Zhang, Anna A. Shabalova, Ai Harashima et autres

Background: Oxytocin (OT) is a nonapeptide hormone produced in the hypothalamus, released into the brain and peripheral circulation, and plays a key role in social behavior. Recent studies indicate that complement component C4a is an OT-binding protein, which modulates plasma OT concentrations …

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Complement component C4a binds to oxytocin and modulates plasma oxytocin concentrations and social behavior in male mice

Yasuhiko Yamamoto, Anpei Zhang, Teruko Yuhi, Ai Harashima et autres

Oxytocin (OT) is a hormone with a short half-life that is released from the posterior pituitary gland into the bloodstream. It plays an important role in childbirth, breastfeeding, and social behavior in humans and animals. However, the endogenous OT system, including plasma …

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Complement Component C4a Shapes Prosociality via Binding of Oxytocin

Yasuhiko Yamamoto, Teruko Yuhi, Anpei Zhang, Ai Harashima et autres

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Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Haruhiro Higashida, Kazumi Furuhara, Olga L. Lopatina, Maria Gerasimenko et autres

Investigating the neurocircuit and synaptic sites of action of oxytocin (OT) in the brain is critical to the role of OT in social memory and behavior. To the same degree, it is important to understand how OT is transported to the brain …

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Oral Supplementation with L-Carnosine Attenuates Social Recognition Deficits in CD157KO Mice via Oxytocin Release

Takahiro Tsuji, Kazumi Furuhara, Maria Gerasimenko, Anna A. Shabalova et autres

The outcomes of supplementation with L-carnosine have been investigated in clinical trials in children with autism spectrum disorder (ASD). However, reports on the effects of L-carnosine in humans have been inconsistent, and the efficacy of L-carnosine supplementation for improving ASD symptoms has …

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An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice

Stanislav M. Cherepanov, Maria Gerasimenko, Teruko Yuhi, Anna A. Shabalova et autres

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Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging

Maria Gerasimenko, Olga L. Lopatina, Anna A. Shabalova, Stanislav M. Cherepanov et autres

The ability of CD38 and CD157 to utilize nicotinamide adenine dinucleotide (NAD) has received much attention because the aging-induced elevation of CD38 expression plays a role in the senescence-related decline in NAD levels. Therefore, it is of interest to examine and compare …

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Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging

Maria Gerasimenko, Olga L. Lopatina, Anna A. Shabalova, Stanislav M. Cherepanov et autres

Abstract The ability of CD38 and CD157 to consume nicotinamide adenine dinucleotide (NAD) has received much attention because aging-induced elevation of CD38 expression plays a role in the senescence-related decline in NAD levels. Therefore, it is of interest to examine and compare …

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Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

Maria Gerasimenko, Stanislav M. Cherepanov, Kazumi Furuhara, Olga L. Lopatina et autres

Oxytocin (OT) is a critical molecule for social recognition and memory that mediates social and emotional behaviours. In addition, OT acts as an anxiolytic factor and is released during stress. Based on the activity of CD38 as an enzyme that produces the …

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Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice

Anna A. Shabalova, Mingkun Liang, Jing Zhong, Zhiqi Huang et autres

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CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Haruhiro Higashida, Minako Hashii, Yukië Tanaka, Shigeru Matsukawa et autres

Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-nucleotide polymorphisms of the CD38 and …

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