Guzel Gafiyatullina

Selenoprotein P deletion ameliorates metabolic stress-associated anxiety-like behavior in male mice

Guzel Gafiyatullina, Anna A. Shabalova, Hisanori Goto, Hein Ko Oo et autres

CONTEXT: Diabetes-associated metabolic stress and anxiety reciprocally influence one another's onset and course. We previously linked excessive selenoprotein P (SeP, encoded by SELENOP in humans) to pathological conditions frequently observed in individuals with diabetes. OBJECTIVE: The present study aimed to clarify the …

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PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO–Atrogene Axis

Qifang Li, Kiyo‐aki Ishii, Kyoko Kamoshita, Kenta Takahashi et autres

Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function and its role in the skeletal muscles remains underinvestigated. Here, …

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Supplemental materials for PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis

Qifang Li, Kiyo‐aki Ishii, Kyoko Kamoshita, Kenta Takahashi et autres

Supplemental materials, including gene set enrichment analysis data and others. Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function …

Supplemental materials for PAC1 deficiency protects immobilization-induced muscle atrophy in obese male mice by suppressing FoxO-atrogene axis.docx

Qifang Li, Kiyo‐aki Ishii, Kyoko Kamoshita, Kenta Takahashi et autres

Supplemental materials, including gene set enrichment analysis data and others. Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function …

Supplemental materials for PAC1 deficiency protects immobilization-induced muscle atrophy in obese male mice by suppressing FoxO-atrogene axis.docx

Qifang Li, Kiyo‐aki Ishii, Kyoko Kamoshita, Kenta Takahashi et autres

Supplemental materials, including gene set enrichment analysis data and others. Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function …

Lauric acid impairs insulin-induced Akt phosphorylation by upregulating SELENOP expression via HNF4α induction

Kyoko Kamoshita, Hirohiko Tsugane, Kiyo‐aki Ishii, Hiroaki Takayama et autres

Selenoprotein P (SeP; encoded by SELENOP in humans, Selenop in rodents) is a hepatokine that is upregulated in the liver of humans with type 2 diabetes. Excess SeP contributes to the onset of insulin resistance and various type 2 diabetes-related complications. We …

jp (code pays fourni par la source)

A Machine Learning Approach to Classification of Drug Reviews in Russian

Ilseyar Alimova, Elena Viktorovna Tutubalina, Julia Alferova, Guzel Gafiyatullina

The automatic extraction of drug side effects from social media has gained popularity in pharmacovigilance. Information extraction methods tailored to medical subjects are essential for the task of drug repurposing and finding drug reactions. In this article, we focus on extracting information …

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Pathohistological assessment of skeletal muscle after direct gene therapy with vegf165 of patients with peripheral arterial diseases

Mikhail O. Mavlikeev, M. V Plotnikov, alexander v . MaKsiMov, Guzel Gafiyatullina et autres

The aim was to elucidate impact of gene therapy with plasmid encoding vegf165 on the muscle tissue pathohistology of patients with peripheral arterial diseases. Twice repeated intramuscular injections of plasmid («Neovaskulgen», RN LP-000671 from 28.09.2011) were performed to 6 patients (ischemia grade …

ru (code pays fourni par la source)