Patricia Lepage

S01-04 Environmental exposures to phenols, phthalates, and PFAS, gut microbiota, and neurodevelopment

A. Davias, S. Lyon-Caen, M. Rolland, N. Iszatt et autres

us, fr, no, Burundi (code pays fourni par la source)

Cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain long-term drug-free remission in paediatric Crohn's disease (CD-HOPE): an open-label, endpoint-blinded, randomised controlled trial

Bénédicte Pigneur, Christine Martinez‐Vinson, Aurélie Bourmaud, Alain Dabadie et autres

fr (code pays fourni par la source)

Associations between the gut microbiota at one-year and neurodevelopment in children from the SEPAGES cohort

Aline Davias, Sarah Lyon-Caen, Nina Iszatt, Céline Monot et autres

Fundamental research indicates a communication between the gut microbiota and the central nervous system, referred to as the microbiota-gut-brain axis. This link is little characterized in humans in the general population. We prospectively investigated the relationships between the gut microbiota composition of …

fr, no, ca (code pays fourni par la source)

A randomized controlled trial of antibiotics targeting adherent and invasive Escherichia coli versus placebo in Crohn’s disease: the TEOREM trial

Franck Carbonnel, Nicolas Barnich, Patricia Lepage, Xavier Hébuterne et autres

BACKGROUND: A subset of patients with ileal Crohn's disease (CD) are colonized with adherent-invasive Escherichia coli (AIEC). OBJECTIVE: This prospective trial tested the efficacy of antibiotics for endoscopic response in CD patients colonized with AIEC. DESIGN: Patients with endoscopically active, ileal CD, …

fr, us (code pays fourni par la source)

Very preterm gut microbiota development from the first week of life to 3.5 years of age: a prospective longitudinal multicenter study

Gaël Toubon, Constance Patin, Johanne Delannoy, Jean‐Christophe Rozé et autres

= 1,307) from 596 PN. Samples were collected at one week after birth, at one month, at the neonatal intensive care unit discharge, and at 3.5 years of age. Over time, the intestinal microbiota of the infants matured progressively, with increasing alpha …

fr (code pays fourni par la source)

Associations between pre- and post-natal exposure to phthalate and DINCH metabolites and gut microbiota in one-year old children

Aline Davias, Sarah Lyon-Caen, Matthieu Rolland, Nina Iszatt et autres

The gut microbiota is a collection of symbiotic microorganisms in the gastrointestinal tract. Its sensitivity to chemicals with widespread exposure, such as phthalates, is little known. We aimed to investigate the impact of perinatal exposure to phthalates on the infant gut microbiota …

fr, no (code pays fourni par la source)

Perinatal Exposure to Phenols and Poly- and Perfluoroalkyl Substances and Gut Microbiota in One-Year-Old Children

Aline Davias, Sarah Lyon-Caen, Matthieu Rolland, Nina Iszatt et autres

The role of the gut microbiota in human health calls for a better understanding of its determinants. In particular, the possible effects of chemicals with widespread exposure other than pharmaceuticals are little known. Our aim was to characterize the sensitivity of the …

fr, no (code pays fourni par la source)

The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis

Patrick J. Gleeson, Nicolas Benech, Jonathan Chemouny, Eleftheria Theodora Metallinou et autres

Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where deglycosylated IgA1 (IgA subclass 1) auto-antigens are recognized by IgG auto-antibodies, forming immune complexes that are deposited in the kidneys, leading …

fr, ie (code pays fourni par la source)

A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome

Claude Bhérer, Robert Eveleigh, Katerina Trajanoska, Janick St-Cyr et autres

Whole genome sequencing (WGS) at high-depth (30X) allows the accurate discovery of variants in the coding and non-coding DNA regions and helps elucidate the genetic underpinnings of human health and diseases. Yet, due to the prohibitive cost of high-depth WGS, most large-scale …

ca, ch, de (code pays fourni par la source)

P900 A PROOF-OF-CONCEPT, PLACEBO-RANDOMIZED CONTROLLED TRIAL TARGETING ADHERENT AND INVASIVE ESCHERICHIA COLI (AIEC) WITH ANTIBIOTICS IN CROHN’S DISEASE: the TEOREM TRIAL

Franck Carbonnel, Nicolas Barnich, Xavier Hébuterne, Patricia Lepage et autres

Abstract Background Adherent-invasive E. coli (AIEC) are found in the ileal mucosa of 21-63% of patients with ileal Crohn’s disease (CD) vs 0-16% of controls. This trial tested the efficacy of antibiotics targeting AIEC in CD patients with ileal involvement, colonized by …

fr, us (code pays fourni par la source)

Longitudinal exposure to antiseizure medications shape gut-derived microbiome, resistome, and metabolome landscape

Camille Dop, Stéphane Auvin, Stanislas Mondot, Patricia Lepage et autres

Abstract The influence of chronically administered host-targeted drugs on the gut microbiome remains less understood compared to antibiotics. We investigated repetitive exposure effects of three common antiseizure medications [carbamazepine (CBZ), valproic acid, and levetiracetam] on the gut microbial composition, resistome, and metabolome …

fr (code pays fourni par la source)

Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress

Magali Monnoye, Catherine Philippe, Sophie Holowacz, Sylvie Rabot et autres

The effect of supplementation with Lactobacillus strains to prevent the consequences of chronic stress on anxiety in mouse strains sensitive to stress and the consequences on gut microbiota have been relatively unexplored. Thus, we administered a Lacticaseibacillus casei LA205 and Lacticaseibacillus paracasei …

fr (code pays fourni par la source)