Very preterm gut microbiota development from the first week of life to 3.5 years of age: a prospective longitudinal multicenter study
Rattachement africain : fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
= 1,307) from 596 PN. Samples were collected at one week after birth, at one month, at the neonatal intensive care unit discharge, and at 3.5 years of age. Over time, the intestinal microbiota of the infants matured progressively, with increasing alpha diversity and decreasing beta diversity. Based on a Dirichlet multinomial mixture clustering approach (DMM), during hospitalization, infants progressed among ten different clusters. At 3.5 years of age, only three clusters were identified. The influence of the gestational age, the neonatal antibiotic administration, and the maternal antibiotic therapy during delivery on the gut microbiota varied over time and depended on the sampling period. Preconceptional maternal body mass index (BMI) was associated with the gut microbiota of infants during the hospitalization period and at 3.5 years of age. Infants with a lower gestational age or those born by Cesarean section shifted between clusters more frequently. Using PICRUSt2, the inferred metabolic pathways revealed a change in the functional capacities of the intestinal microbiota over time. We found that preconceptional maternal BMI was the only consistent perinatal factor influencing the development of the gut microbiota over time. After hospital discharge, infants exhibited a transition toward a microbiota community similar to that of adults by 3.5 years of age, in accordance with the functional metabolic pathways of the gut microbiota.IMPORTANCEThis study is among the very few reports analyzing the gut microbiota development in very preterm infants over time in a large, multicenter population of 596 children from a well-described nationwide birth cohort, with a follow-up until the age of 3.5 years. The maturation of the intestinal microbiota was confirmed to occur over time, with increased alpha diversity and decreased beta diversity. Specifically, 13 microbiota clusters were identified during the hospitalization period, while and only three clusters were observed at 3.5 years. Infants born prematurely or via Cesarean section exhibited a less stable microbiota, frequently shifting clusters. A number of perinatal factors were identified as influencing the development of the microbiota. Among these, the preconceptional maternal BMI emerged as the only consistent factor up to 3.5 years. The metabolic pathways of the microbiota evolved over time, in accordance with the maturation of the gut microbiota.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Very preterm gut microbiota development from the first week of life to 3.5 years of age: a prospective longitudinal multicenter study
- Date Crossref
- 01/04/2025
- Éditeur
- American Society for Microbiology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Inserm pays non établi dans la noticeOrganisme public
-
Université Paris Cité Physiopathologie et Pharmacotoxicologie Placentaire Humaine Microbiote Pré & Postnatal pays non établi dans la noticeUniversité ou école supérieure
-
Sorbonne Paris Cité pays non établi dans la noticeInstitution
-
Centre de Recherche Épidémiologie et Statistique pays non établi dans la noticeStructure de recherche
-
Physiopathologie et pharmacotoxicologie placentaire humaine : Microbiote pré & post natal pays non établi dans la noticeStructure de recherche
-
ParisTech pays non établi dans la noticeUniversité ou école supérieure
-
Université Paris-Saclay Institut Micalis pays non établi dans la noticeUniversité ou école supérieure
-
Microbiologie de l’alimentation au service de la santé pays non établi dans la noticeStructure de recherche
-
Institut National de Recherche pour l'Agriculture pays non établi dans la noticeOrganisme public
-
PhysioPathologie des Adaptations Nutritionnelles pays non établi dans la noticeStructure de recherche
-
Nantes Université pays non établi dans la noticeUniversité ou école supérieure
-
FHU PREMA pays non établi dans la noticeInstitution
Inserm, Physiopathologie et Pharmacotoxicologie Placentaire Humaine Microbiote Pré & Postnatal — Université Paris Cité et Sorbonne Paris Cité, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.