Catherine Philippe

Distinct Adrenal Medulla Activity in Germ‐Free Versus Conventional Male Rats Under Acute and Chronic Stress

Camille Etienne, Claire Bernat, Magali Monnoye, Virginie Andry et autres

It has now been well established that gut microbiota significantly influences emotional and neuroendocrine responses to stress. Specifically, multiple pieces of evidence from various preclinical models indicate that gut microbiota regulates the response of the hypothalamic-pituitary-adrenocortical (HPA) axis to acute and chronic …

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Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism

on behalf of the SysPharmPediA consortium, Naika Prince, Lucia Natalia Peralta Marzal, Léa Roussin et autres

Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD development and severity, recent studies have focused on elucidating the …

Anorexia nervosa symptoms are induced after specific gut microbiota dysbiosis transfer in germ-free mice

Tristan Gabriel-Segard, Christine Heberden, Stanislas Mondot, Maëva Duquesnoy et autres

Anorexia nervosa (AN) is the most severe and life-threatening eating disorder. Its pathophysiology remains largely unknown, and no effective treatment currently exists for severe forms of the disease. Gut microbiota (GM) dysbiosis has been consistently reported in AN; however, no study has …

fr (code pays fourni par la source)

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye et autres

BACKGROUND & AIMS: Alternating periods of excessive and restrained eating results in weight cycling ('yo-yo' effect), a suspected risk factor for eating behavior dysregulation such as binge eating. The hypothesis that recurrent diet alternation alters hedonic feeding regulation by changing either or …

fr (code pays fourni par la source)

Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism

Naika Prince, Lucía N. Peralta Marzal, Léa Roussin, Magali Monnoye et autres

Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD development and severity, recent studies have focused on elucidating the …

nl, fr, fi (code pays fourni par la source)

Yo-yo dieting deregulates feeding behavior in mice via the induction of durable gut dysbiosis

Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye et autres

Abstract Background & Aims Alternating periods of excessive and restrained eating results in weight cycling, a known risk factor for eating behavior dysregulation such as binge eating. Diet alternation also induces changes in intestinal microbiota composition. We tested the hypothesis that recurrent …

fr (code pays fourni par la source)

MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis

Yara El Morr, Mariela Fürstenheim, Martin Mestdagh, Katarzyna Franciszkiewicz et autres

Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors and responds to such changes remains unclear. Here, we describe a protective mechanism by which mucosal-associated invariant T (MAIT) cells detect microbiota metabolites produced upon intestinal inflammation and promote tissue repair. …

fr (code pays fourni par la source)

Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress

Magali Monnoye, Catherine Philippe, Sophie Holowacz, Sylvie Rabot et autres

The effect of supplementation with Lactobacillus strains to prevent the consequences of chronic stress on anxiety in mouse strains sensitive to stress and the consequences on gut microbiota have been relatively unexplored. Thus, we administered a Lacticaseibacillus casei LA205 and Lacticaseibacillus paracasei …

fr (code pays fourni par la source)

Modulation of gut microbiota by antibiotics did not affect anhedonia in a high-fat diet-induced model of depression in male mice

Magali Monnoye, Pauline Flauss, Catherine Philippe, Nathalie Castanon et autres

Background: Long-term consumption of a high-fat diet (HFD) causes obesity and is a risk factor for depression. The HFD has a significant impact on the gut microbiota, and dysbiosis of the microbiota is now associated with certain psychiatric disorders such as anxiety …

fr (code pays fourni par la source)

Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease

Florian Plaza Oñate, Célia Chamignon, Sebastian D. Burz, Nicolas Lapaque et autres

Non-alcoholic fatty liver disease (NAFLD) affects about 20–40% of the adult population in high-income countries and is now a leading indication for liver transplantation and can lead to hepatocellular carcinoma. The link between gut microbiota dysbiosis and NAFLD is now clearly established. …

fr (code pays fourni par la source)

Adlercreutzia equolifaciens Is an Anti-inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease

Florian Plaza-Onate, Célia Chamignon, Sebastian D. Burz, Nicolas Lapaque et autres

Non-alcoholic fatty liver disease (NAFLD) affects about 20–40% of the adult population in high-income countries and is now a leading indication for liver transplantation and can drive to hepatocellular carcinoma. The link between gut microbiota dysbiosis and NAFLD is now clearly established. …

fr (code pays fourni par la source)

Droit et protection de l’enfant victime de violences conjugales

Catherine Philippe