Johannes Zander

Rising resistance to linezolid among critically ill patients calls for model-informed precision dosing in the empirical setting

Johannes Starp, Antonia Leonhardt, Jette Jung, Maximilian Stoschus et autres

Abstract Linezolid is important for treating infections caused by Gram-positive bacteria resistant to first-line agents. Severe infections often require empirical therapy before pathogen identification and susceptibility testing. This evaluation aims to compare different empirical linezolid dosing strategies in intensive care unit (ICU) …

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The β-lactamase inhibitor concentration-dependent minimum inhibitory concentration (MICcBLI) as methodology to assess the pharmacokinetic/pharmacodynamic relationship of piperacillin/tazobactam for dosing optimization

Malin Andersson, Franz Weber, Ferdinand Anton Weinelt, Nicole Zimmermann et autres

BACKGROUND AND OBJECTIVES: The MIC, determined in vitro using a fixed tazobactam concentration, is used as basis for the pharmacokinetic/pharmacodynamic (PK/PD) index of piperacillin/tazobactam. The β-lactamase inhibitor (BLI) concentration-dependent MIC (MICcBLI) represents a promising alternative PD metric accounting for varying tazobactam concentrations …

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Towards model-informed precision dosing of intravenous linezolid: a multicentre external evaluation of pharmacokinetic models in critically ill adults

Johannes Starp, Antonia Leonhardt, Michael Zöller, Christina Scharf et autres

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A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly

Daming Kong, Jason A. Roberts, Jeffrey Lipman, Fabio Silvio Taccone et autres

The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP ( f UNB_PIP ). This has led to a plethora of subgroup-specific models, increasing …

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Angiopoietin II in Critically Ill Septic Patients: A Post Hoc Analysis of the DRAK Study

Veronika Bucher, Helen Graf, Johannes Zander, Uwe Liebchen et autres

Introduction: Angiopoietin II (Ang-II) plays a pivotal role in the development of microcirculatory dysfunction as it provokes endothelial barrier disruption in patients with sepsis or septic shock. In particular, those with acute kidney injury show high Ang-II concentrations. So far, it is …

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Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting

Sebastian Greppmair, Alexander Brinkmann, Anka C. Roehr, Otto Roman Frey et autres

PURPOSE: Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising to individualize dosing; however, the transferability of published models to external populations is uncertain. This study aimed to externally evaluate the …

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Cefepime Population Pharmacokinetics, Antibacterial Target Attainment, and Estimated Probability of Neurotoxicity in Critically Ill Patients

Muhammad Bilal, Michael Zöller, Uwe Fuhr, Ulrich Jaehde et autres

and a PTA of 90%, a dose of 1,333 mg q8h was found to be related to a probability of neurotoxicity of ≤20% and to cover MICs up to 2 mg/L. Continuous infusion appears to be superior to other dosing regimens by …

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Systematic Evaluation of Voriconazole Pharmacokinetic Models without Pharmacogenetic Information for Bayesian Forecasting in Critically Ill Patients

Simon Kallee, Christina Scharf, Lea Marie Schatz, Michael Paal et autres

Voriconazole (VRC) is used as first line antifungal agent against invasive aspergillosis. Model-based approaches might optimize VRC therapy. This study aimed to investigate the predictive performance of pharmacokinetic models of VRC without pharmacogenetic information for their suitability for model-informed precision dosing. Seven …

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No clinically relevant removal of meropenem by cytokine adsorber CytoSorb® in critically ill patients with sepsis or septic shock

Uwe Liebchen, Christina Scharf, Michael Zöller, Ferdinand Anton Weinelt et autres

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Self-Collected Gargle Lavage Allows Reliable Detection of SARS-CoV-2 in an Outpatient Setting

Johannes Zander, Stephan Scholtes, Maximilian Ottinger, Marcel Kremer et autres

The SARS-CoV-2 pandemic still strains health care systems worldwide. While COVID-19 testing is considered an essential pillar in combating this infectious disease, shortages in supplies and trained health care personnel often limit the procurement of patient samples, in particular in outpatient settings. …

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Comparing posaconazole and itraconazole for antifungal prophylaxis in critically ill lung transplant recipients: Efficacy and plasma concentrations

Simon Kallee, Christina Scharf, Ines Schroeder, Michael Paal et autres

BACKGROUND: Posaconazole and itraconazole are commonly used for systemic antifungal prophylaxis after lung transplantation. The aim of this study on critically ill lung transplant recipients was to assess the rate of adequate plasma concentrations and the frequency of fungal-induced transitions from antifungal …

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A Model‐Based Approach to Assess Unstable Creatinine Clearance in Critically Ill Patients

Sami Ullah, Michael Zöller, Ulrich Jaehde, Mikayil Huseyn‐Zada et autres

Creatinine clearance is an important tool to describe the renal elimination of drugs in pharmacokinetic (PK) evaluations and clinical practice. In critically ill patients, unstable kidney function invalidates the steady-state assumption underlying equations, such as Cockcroft-Gault. Although measured creatinine clearance (mCrCL) is …

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