Johannes Starp

Real-world population pharmacokinetic modeling of elexacaftor, tezacaftor, and ivacaftor

Alexandra K. Kunzelmann, S. Naehrig, Christina Shad, M. Breuling et autres

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Rising resistance to linezolid among critically ill patients calls for model-informed precision dosing in the empirical setting

Johannes Starp, Antonia Leonhardt, Jette Jung, Maximilian Stoschus et autres

Abstract Linezolid is important for treating infections caused by Gram-positive bacteria resistant to first-line agents. Severe infections often require empirical therapy before pathogen identification and susceptibility testing. This evaluation aims to compare different empirical linezolid dosing strategies in intensive care unit (ICU) …

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Towards model-informed precision dosing of intravenous linezolid: a multicentre external evaluation of pharmacokinetic models in critically ill adults

Johannes Starp, Antonia Leonhardt, Michael Zöller, Christina Scharf et autres

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Optimizing phenobarbital dosing in critically ill patients with refractory and superrefractory status epilepticus using a population pharmacokinetic model

Maximilian Stoschus, Moritz L. Schmidbauer, Johannes Starp, Stefan Kunst et autres

OBJECTIVE: Current weight-based dosing fails to account for pharmacokinetic variability in refractory and superrefractory status epilepticus (RSE, SRSE). However, understanding pharmacokinetics in critically ill patients with varying degrees of organ dysfunction can improve both safety and efficacy. Hence, this study aims to …

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Predictive performance of multi-model approaches for model-informed precision dosing of piperacillin in critically ill patients

Lea Marie Schatz, Sebastian Greppmair, Alexandra K. Kunzelmann, Johannes Starp et autres

OBJECTIVES: Piperacillin (PIP)/tazobactam is a frequently prescribed antibiotic; however, over- or underdosing may contribute to toxicity, therapeutic failure, and development of antimicrobial resistance. An external evaluation of 24 published PIP-models demonstrated that model-informed precision dosing (MIPD) can enhance target attainment. Employing various …

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Can linezolid be validly measured in endotracheal aspiration in critically ill patients? A proof-of-concept trial

Diana Rebholz, Uwe Liebchen, Michael Paal, Michael Vogeser et autres

BACKGROUND: Therapeutic drug monitoring (TDM) of anti-infectives such as linezolid is routinely performed in blood of intensive care unit (ICU) patients to optimize target attainment. However, the concentration at the site of infection is considered more important for a successful therapy. Until …

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