Jette Jung

Rising resistance to linezolid among critically ill patients calls for model-informed precision dosing in the empirical setting

Johannes Starp, Antonia Leonhardt, Jette Jung, Maximilian Stoschus et autres

Abstract Linezolid is important for treating infections caused by Gram-positive bacteria resistant to first-line agents. Severe infections often require empirical therapy before pathogen identification and susceptibility testing. This evaluation aims to compare different empirical linezolid dosing strategies in intensive care unit (ICU) …

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The β-lactamase inhibitor concentration-dependent minimum inhibitory concentration (MICcBLI) as methodology to assess the pharmacokinetic/pharmacodynamic relationship of piperacillin/tazobactam for dosing optimization

Malin Andersson, Franz Weber, Ferdinand Anton Weinelt, Nicole Zimmermann et autres

BACKGROUND AND OBJECTIVES: The MIC, determined in vitro using a fixed tazobactam concentration, is used as basis for the pharmacokinetic/pharmacodynamic (PK/PD) index of piperacillin/tazobactam. The β-lactamase inhibitor (BLI) concentration-dependent MIC (MICcBLI) represents a promising alternative PD metric accounting for varying tazobactam concentrations …

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Perioperative Antibiotikaprophylaxe – die neue S3-Leitlinie

Rika Draenert, Alexandra Weber, Jette Jung, Lukas Arenz

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Importance of the neutrophil-to-lymphocyte ratio as a marker for microbiological specimens in critically ill patients after liver or lung transplantation

Steffen B. Wiegand, Michael Paal, Jette Jung, Markus Otto Guba et autres

PURPOSE: The correct and early diagnosis of an infection is pivotal for patients, especially if the patients are immunocompromised. Various infection markers are used in clinics with different advantages and disadvantages. The neutrophil-to-lymphocyte ratio (NLR) is a cost effective parameter easily obtained …

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In vitro activity of cefiderocol against European Enterobacterales, including isolates resistant to meropenem and recentβ-lactam/β-lactamase inhibitor combinations

Anne Santerre Henriksen, Fabio Arena, Marie Attwood, Rafael Cantón et autres

ABSTRACT Carbapenem-resistant Enterobacterales represent a major health threat and have few approved therapeutic options. Enterobacterales isolates were collected from hospitalized inpatients from 49 sites in six European countries (1 January–31 December 2020) and underwent susceptibility testing to cefiderocol and β-lactam/β-lactamase inhibitor combinations. …

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In vitro activity of cefiderocol against European Pseudomonas aeruginosa and Acinetobacter spp., including isolates resistant to meropenem and recent β-lactam/β-lactamase inhibitor combinations

Anne Santerre Henriksen, Katy Jeannot, Antonio Oliver, John David Perry et autres

ABSTRACT Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. represent major threats and have few approved therapeutic options. Non-‍fermenting Gram-negative isolates were collected from hospitalized inpatients from 49 sites in 6 European countries between 01 January 2020 and 31 December 2020 and underwent susceptibility …

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Effect and sustainability of a stepwise implemented multidisciplinary antimicrobial stewardship programme in a university hospital emergency department

Lukas Arenz, Annika Porger, Michaela De Michel, Alexandra Weber et autres

Abstract Objectives To explore effectiveness and sustainability of guideline adherence and antibiotic consumption after establishing treatment guidelines and initiating antimicrobial stewardship (AMS) ward rounds in a university hospital emergency department (ED). Methods Data were gathered retrospectively from 2017 to 2021 in the …

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Ecological effects of selective oral decontamination on multidrug-resistance bacteria acquired in the intensive care unit: a case–control study over 5 years

Boacheng Wang, Josef Briegel, Wolfgang A. Krueger, Rika Draenert et autres

PURPOSE: This case-control study investigated the long-term evolution of multidrug-resistant bacteria (MDRB) over a 5-year period associated with the use of selective oropharyngeal decontamination (SOD) in the intensive care unit (ICU). In addition, effects on health care-associated infections and ICU mortality were …

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Impact and Sustainability of Antibiotic Stewardship on Antibiotic Prescribing in Visceral Surgery

Magdalena Monika Gruber, Alexandra Weber, Jette Jung, Jens Werner et autres

Background: Antibiotic stewardship (AS) ward rounds are a core element in clinical care for surgical patients. Therefore, we aimed to analyze the impact of surgical AS ward rounds on antibiotic prescribing, and the sustainability of the effect after the AS interventions are …

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Comparing posaconazole and itraconazole for antifungal prophylaxis in critically ill lung transplant recipients: Efficacy and plasma concentrations

Simon Kallee, Christina Scharf, Ines Schroeder, Michael Paal et autres

BACKGROUND: Posaconazole and itraconazole are commonly used for systemic antifungal prophylaxis after lung transplantation. The aim of this study on critically ill lung transplant recipients was to assess the rate of adequate plasma concentrations and the frequency of fungal-induced transitions from antifungal …

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Prevalence, Resistance Rates, and Risk Factors of Pathogens in Routine Bile Cultures Obtained during Endoscopic Retrograde Cholangiography

Florian Paul Reiter, Wolfgang A. Obermeier, Jette Jung, Gerald Denk et autres

INTRODUCTION AND OBJECTIVE: Acute cholangitis is a life-threatening condition. The early initiation of antibiotic therapy significantly impacts the course of disease. Only few data are available on distribution and resistance profiles of bile pathogens. Here, we report on an analysis of routinely …

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Bei Pneumonie-Symptomen immer auch an atypische Erreger denken!

Rika Draenert, Jette Jung, Ulrich Seybold, Johannes Richard Bogner

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