Lea Marie Schatz

Towards model-informed precision dosing of intravenous linezolid: a multicentre external evaluation of pharmacokinetic models in critically ill adults

Johannes Starp, Antonia Leonhardt, Michael Zöller, Christina Scharf et autres

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Predictive performance of multi-model approaches for model-informed precision dosing of piperacillin in critically ill patients

Lea Marie Schatz, Sebastian Greppmair, Alexandra K. Kunzelmann, Johannes Starp et autres

OBJECTIVES: Piperacillin (PIP)/tazobactam is a frequently prescribed antibiotic; however, over- or underdosing may contribute to toxicity, therapeutic failure, and development of antimicrobial resistance. An external evaluation of 24 published PIP-models demonstrated that model-informed precision dosing (MIPD) can enhance target attainment. Employing various …

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Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting

Sebastian Greppmair, Alexander Brinkmann, Anka C. Roehr, Otto Roman Frey et autres

PURPOSE: Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising to individualize dosing; however, the transferability of published models to external populations is uncertain. This study aimed to externally evaluate the …

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Developing a Method for Quantifying Meropenem in Children—Volumetric Adsorptive Microsampling Versus Plasma Sampling

Ola Ramadan, Lea Marie Schatz, Ingeborg Alijda van den Heuvel, Katja Masjosthusmann et autres

BACKGROUND: Meropenem is a carbapenem antibiotic often used in pediatric intensive care units due to its broad spectrum of activity. Therapeutic drug monitoring (TDM) is a useful tool to increase the effectiveness of meropenem by adjusting the dose based on plasma levels; …

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Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy

Lea Marie Schatz, Alexander Brinkmann, Anka C. Röhr, Otto Roman Frey et autres

and Bayesian dosing MPE within |2%|, MAPE <30%). Our study revealed the O'Jeanson model as the best-predicting model for intermittent infusion. However, most of the selected PopPK models are suitable for MIPD in CRRT patients when one therapeutic drug monitoring sample is …

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Systematic Evaluation of Voriconazole Pharmacokinetic Models without Pharmacogenetic Information for Bayesian Forecasting in Critically Ill Patients

Simon Kallee, Christina Scharf, Lea Marie Schatz, Michael Paal et autres

Voriconazole (VRC) is used as first line antifungal agent against invasive aspergillosis. Model-based approaches might optimize VRC therapy. This study aimed to investigate the predictive performance of pharmacokinetic models of VRC without pharmacogenetic information for their suitability for model-informed precision dosing. Seven …

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Therapeutisches Drugmonitoring und pharmakokinetische Modelle als Strategie zur rationalen Antibiotikatherapie bei IntensivpatientInnen

Lea Marie Schatz, Michael Zöller, Christina Scharf, Uwe Liebchen

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