Dietary linoleic acid lowering alone does not lower arachidonic acid or endocannabinoids among women with overweight and obesity: A randomized, controlled trial
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Le résumé fourni par la source
Abstract The linoleic acid (LA)‐arachidonic acid (ARA)‐inflammatory axis suggests dietary LA lowering benefits health because it lowers ARA and ARA‐derived endocannabinoids (ECB). Dietary LA reduction increases concentrations of omega‐3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DHA derived ECB. The aim of this study was to examine targeted reduction of dietary LA, with and without EPA and DHA, on plasma EPA and DHA and ECB (2‐arachidonoyl glycerol [2‐AG], anandamide [AEA], and docosahexaenoyl ethanolamide [DHA‐EA]). Healthy, pre‐menopausal women (n = 62, BMI 30 ± 3 kg/m2, age 35 ± 7 years; mean ± SD) were randomized to three 12‐week controlled diets: (1) high LA, low omega‐3 EPA and DHA (H6L3); (2) low LA, low omega‐3 EPA and DHA (L6L3); or (3) low LA, high omega‐3 EPA and DHA (L6H3). Baseline plasma fatty acids and ECB were similar between diets. Starting at 4 weeks, L6L3 and L6H3 lowered plasma LA compared to H6L3 (p < 0.001). While plasma ARA changed from baseline by 8% in L6L3 and −8% in L6H3, there were no group differences. After 4 weeks, plasma EPA and DHA increased from baseline in women on the L6H3 diet (ps < 0.001) and were different than the H6L3 and L6L3 diets. No differences were found between diets for AEA or 2‐AG, however, in L6L3 and L6H3, AEA increased by 14% (ps < 0.02). L6H3 resulted in 35% higher DHA‐EA (p = 0.013) whereas no changes were seen with the other diets. Lowering dietary LA did not result in the expected changes in fatty acids associated with the LA‐ARA inflammatory axis in women with overweight and obesity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Dietary linoleic acid lowering alone does not lower arachidonic acid or endocannabinoids among women with overweight and obesity: A randomized, controlled trial
- Date Crossref
- 01/11/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute of Diabetes and Digestive and Kidney Diseases pays non établi dans la noticeStructure de recherche
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National Institute on Alcohol Abuse and Alcoholism pays non établi dans la noticeStructure de recherche
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National Institutes of Health Clinical Center pays non établi dans la noticeÉtablissement de santé
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National Institute of Neurological Disorders and Stroke pays non établi dans la noticeStructure de recherche
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Institute on Aging pays non établi dans la noticeOrganisation à but non lucratif
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National Institute on Aging pays non établi dans la noticeStructure de recherche
National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases et National Institute on Alcohol Abuse and Alcoholism, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.