Masachika Ikegami

PDGFRA amplification could be a poor prognostic factor of advanced undifferentiated pleomorphic sarcoma in a comprehensive genomic profiling cohort

Hiroshi Kobayashi, Masachika Ikegami, Liuzhe Zhang, Koichi Okajima et autres

BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) is the most common pleomorphic sarcoma, and its genomic landscape has been analysed, albeit in small numbers. This study aimed to clarify the relationship between gene variants and the prognosis of patients with advanced UPS. METHODS: This …

jp, gb (code pays fourni par la source)

Real-world clinical characteristics and outcomes in patients with HER2-mutant non-small cell lung cancer (NSCLC) who received second-line treatment: A nationwide database analysis in Japan

Yuji Uehara, Masachika Ikegami, Shinji Kohsaka, Hana Kimura et autres

BACKGROUND: Although human epidermal growth factor receptor 2 (HER2)-targeted therapies have been approved for HER2-mutant NSCLC, real-world outcome data especially in the second-line setting remains limited. METHODS: This non-interventional study utilized the Center for Cancer Genomics and Advanced Therapeutics national database to …

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Differences Among Genomic Profiling Tests for Bone and Soft-Tissue Sarcomas in a Universal Health Insurance System

Satoshi Kamio, Masachika Ikegami, Rina Kitada, Satoshi Miwa et autres

BACKGROUND: Accurate identification of gene fusions is critical for precision oncological approaches to sarcomas, where specific fusion genes are actionable targets of tyrosine kinase (TK) inhibitors. This study provides a descriptive overview of the real-world use, under a universal health insurance program, …

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Abstract 7503: Spatio-temporal analysis of EGFR inhibitor resistant tumor epithelial clusters

Shuichi Watanabe, Yoshiyuki Suehara, Masachika Ikegami, Soohwan Park et autres

Abstract [Background]Drug-tolerant persister (DTP) cells are a reversible drug-insensitive tumor subpopulation implicated in minimal residual disease (MRD) and recurrence. However, their emergence mechanisms and therapeutic vulnerabilities remain unclear. We previously tracked clonal dynamics in vivo using genetic barcodes and showed that expansion …

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Supplementary Figure 1 from Germline Pathogenic Variant Prediction Model for Tumor-Only Sequencing Based on Japanese Clinicogenomic Database

Masachika Ikegami, Liuzhe Zhang, Makoto Hirata (17388794), Tatsuro Yamaguchi (24244014) et autres

Supplementary Figures S1-S6

Supplementary Table 1 from Germline Pathogenic Variant Prediction Model for Tumor-Only Sequencing Based on Japanese Clinicogenomic Database

Masachika Ikegami, Liuzhe Zhang, Makoto Hirata (17388794), Tatsuro Yamaguchi (24244014) et autres

Supplementary Tables S1-S12

PDGFRA amplification could be a poor prognostic factor of advanced undifferentiated pleomorphic sarcoma in a comprehensive genomic profiling cohort

Hiroshi Kobayashi, Masachika Ikegami, Liuzhe Zhang, Koichi Okajima et autres

jp (code pays fourni par la source)

Germline Pathogenic Variant Prediction Model for Tumor-Only Sequencing Based on Japanese Clinicogenomic Database

Masachika Ikegami, Liuzhe Zhang, Makoto Hirata, Tatsuro Yamaguchi et autres

PURPOSE: Germline pathogenic variants (GPV) are frequently identified as secondary findings in cancer gene panel testing. Due to limited data on germline conversion rates (GCR) in the Japanese population, clinical decisions have relied on European Society for Medical Oncology (ESMO) criteria. We …

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Supplementary Figures from High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer

Sho Mizuno, Masachika Ikegami, Takafumi Koyama, Kuniko Sunami et autres

Figure S1 to S17

Supplementary Tables from High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer

Sho Mizuno, Masachika Ikegami, Takafumi Koyama, Kuniko Sunami et autres

Table S1 to S9

Analysis of comprehensive genomic profiling test for Ewing sarcoma in pediatric patients and adults using the nationwide clinical and genomic database in Japan

Satoshi Kamio, Koichi Ogura, Yoshiyuki Suehara, Rina Kitada et autres

BACKGROUND: Ewing sarcoma (ES) is a malignant type of bone and soft tissue tumor with EWSR1-ETS gene fusions as the primary driver alteration. Incidence is higher in White populations compared to Black and Asian populations. Researchers use next-generation sequencing to identify alterations …

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Data from Functional Analysis of Rare RAS Variants of Unknown Significance

Soohwan Park, Masachika Ikegami, Rina Kitada, Kazuya Takamochi et autres

Abstract The RAS gene is frequently mutated in human cancers. Whereas the functional significance of frequent mutations is well established, the significance of rare mutations remains unknown. This study aimed to comprehensively investigate the function of rare RAS variants and provide new …