Yoshiyuki Suehara

Differences Among Genomic Profiling Tests for Bone and Soft-Tissue Sarcomas in a Universal Health Insurance System

Satoshi Kamio, Masachika Ikegami, Rina Kitada, Satoshi Miwa et autres

BACKGROUND: Accurate identification of gene fusions is critical for precision oncological approaches to sarcomas, where specific fusion genes are actionable targets of tyrosine kinase (TK) inhibitors. This study provides a descriptive overview of the real-world use, under a universal health insurance program, …

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Abstract 7503: Spatio-temporal analysis of EGFR inhibitor resistant tumor epithelial clusters

Shuichi Watanabe, Yoshiyuki Suehara, Masachika Ikegami, Soohwan Park et autres

Abstract [Background]Drug-tolerant persister (DTP) cells are a reversible drug-insensitive tumor subpopulation implicated in minimal residual disease (MRD) and recurrence. However, their emergence mechanisms and therapeutic vulnerabilities remain unclear. We previously tracked clonal dynamics in vivo using genetic barcodes and showed that expansion …

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Editorial Expression of Concern: Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer

Christine Marie Lovly, Nerina T. McDonald, Heidi Chen, Sandra Ortiz‐Cuaran et autres

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Analysis of comprehensive genomic profiling test for Ewing sarcoma in pediatric patients and adults using the nationwide clinical and genomic database in Japan

Satoshi Kamio, Koichi Ogura, Yoshiyuki Suehara, Rina Kitada et autres

BACKGROUND: Ewing sarcoma (ES) is a malignant type of bone and soft tissue tumor with EWSR1-ETS gene fusions as the primary driver alteration. Incidence is higher in White populations compared to Black and Asian populations. Researchers use next-generation sequencing to identify alterations …

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Potential Involvement of Myostatin in Smooth Muscle Differentiation in Pleomorphic Leiomyosarcoma

Hiroko Onagi, Raku Son, Akiko Oguchi, Kei Sano et autres

High-grade sarcomas often lack typical morphological features and exhibit no clear differentiation, often leading to a diagnosis of undifferentiated sarcoma (US). Pleomorphic leiomyosarcoma (PLMS) is a high-grade sarcoma consisting of a typical leiomyosarcoma (LMS) component alongside dedifferentiated high-grade areas. A few decades …

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Patient and physician preferences for cancer panel testing in Japan: a best-worst scaling study

Yoshiyuki Suehara, Kazuo Hasegawa, Yoshiyuki Majima, Naoyuki Mita et autres

OBJECTIVE: To examine the relative importance of the benefits and burdens of comprehensive genomic profiling testing from the perspectives of patients and physicians in Japan. DESIGN: Cross-sectional preference elicitation via a mixed method centred on best-worst scaling (BWS) case 2 (profile case), …

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Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers

Yuya Terashima, Soohwan Park, Hiroshi Ikeuchi, Takuo Hayashi et autres

Lung adenocarcinomas (LUADs) in never-smokers exhibit distinct molecular profiles from those of smokers, and their driver mutations are quite divergent. We aimed to evaluate the utility of RNA-seq for the molecular profiling of LUAD in Japanese never or light smokers. A hybridization …

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Clinical presentation and prognostic factors of eyelid sebaceous carcinoma

Yukiko Aihara, Masachika Ikegami, Yoshiyuki Suehara, Takane Watanabe et autres

PURPOSE: To clarify the demographics, clinical features, outcomes, and prognostic factors of Japanese patients with eyelid sebaceous carcinoma. STUDY DESIGN: Retrospective study. METHODS: Fifty-two patients with eyelid sebaceous carcinoma diagnosed histopathologically at the National Cancer Center Hospital in Japan between 2013 and …

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Abstract 1131: Comprehensive genomic profiling in osteosarcoma: Insights from Japanese cohorts and the AACR Project GENIE

Yoshiyuki Suehara, Rina Kitada, Masachika Ikegami, Satoshi Kamio et autres

Abstract Background: Osteosarcoma (OS), the most common primary malignant bone tumor, presents challenges in treatment, especially in metastatic or recurrent cases. Genomic profiling may offer novel therapeutic approaches by identifying actionable mutations. This study utilizes data from the Japanese Center for Cancer …

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507P Analysis of cancer multigene panel testing for osteosarcoma using the Center for Cancer Genomics and Advanced Therapeutics database in Japan

Yoshiyuki Suehara, Ryuki Kitada, Satoshi Kamio, Koichi Ogura et autres

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Analysis of cancer multigene panel testing for osteosarcoma in pediatric and adults using the center for cancer genomics and advanced therapeutics database in Japan

Yoshiyuki Suehara, Rina Kitada, Satoshi Kamio, Koichi Ogura et autres

jp, us, gb (code pays fourni par la source)

NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts

Keita Sasa, Raku Son, Akiko Oguchi, Karin Ashizawa et autres

Gastrointestinal stromal tumors (GISTs) are typically characterized by activating mutations of the KIT proto-oncogene receptor tyrosine kinase (KIT) or platelet-derived growth factor receptor alpha (PDGFRA). Recently, the neurotrophic tyrosine receptor kinase (NTRK) fusion was reported in a small subset of wild-type GIST. …

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