Savvina Chortarea

Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury

Namrata Kewalramani, Carlos Machahua, Thomas M. Marti, Cas Zandbergen et autres

BACKGROUND: Acute respiratory distress syndrome (ARDS) causes high mortality and has no specific pharmacological treatment. Scarcity of drugs against ARDS is in part due to the lack of models for ARDS. As raised serum heme levels are associated with higher mortality in …

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Go with the flow: An in vitro model of a mature endothelium for the study of the bioresponse of IV injectable nanomedicines

Niusha Nikravesh, Alexandra Rippl, Tobias Hoch, Stephanie Eitner et autres

The first exposure of intravenously (IV) administered nanomedicines in vivo is to endothelial cells (ECs) lining blood vessels. While it is known that in vitro endothelium models to assess responses to circulating nanoparticles require shear stress, there is no consensus on when …

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P26-01 Hexagonal boron nitride (hBN) and hBN-reinforced thermoplastic polyurethane composite: an in vitro hazard characterization using human skin and lung cells

Michela Carlin, Jasjeet Kaur, Dinu Zinovie Ciobanu, Zhigang Song et autres

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Hazard assessment of hexagonal boron nitride and hexagonal boron nitride reinforced thermoplastic polyurethane composites using human skin and lung cells

Michela Carlin, Jasreen Kaur, Dinu Zinovie Ciobanu, Zheng‐Mei Song et autres

Hexagonal boron nitride (hBN) is an emerging two-dimensional material attracting considerable attention in the industrial sector given its innovative physicochemical properties. Potential risks are associated mainly with occupational exposure where inhalation and skin contact are the most relevant exposure routes for workers. …

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Go with the Flow: An in Vitro Model of a Mature Endothelium for the Study of the Bioresponse of IV Injectable Nanomedicines

Niusha Nikravesh, Alexandra Rippl, Tobias Hoch, Amy Barton Pai et autres

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Hazard Assessment of Hexagonal Boron Nitride and Hexagonal Boron Nitride Reinforced Thermoplastic Polyurethane Composites Using Human Skin and Lung Cells

Michela Carlin, Jasreen Kaur, Dinu Zinovie Ciobanu, Zheng‐Mei Song et autres

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Transcriptomic profiling reveals differential cellular response to copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta

Savvina Chortarea, Govind Sharan Gupta, Laura Aliisa Saarimäki, Woranan Netkueakul et autres

The growing nanoparticulate pollution (e.g. engineered nanoparticles (NPs) or nanoplastics) has been shown to pose potential threats to human health. In particular, sensitive populations such as pregnant women and their unborn children need to be protected from harmful environmental exposures. However, developmental …

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73 Evaluating the Risks of Prolonged Exposure to Graphene Oxide on Healthy and Streptococcus Pneumoniae Infected 3D Reconstituted Human Lung Cultures

Tina Buerki‐Thurnherr, Susanne Nigg, Werner C. Albrich, Christian R. Kahlert et autres

Abstract The growing production of graphene oxide (GO) and GO-based products has led to an increased risk of human exposure and caused scientific and public concern about human health and safety. Even though human exposure to GO can occur via different pathways, …

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Gene expression profiling of human macrophages after graphene oxide and graphene nanoplatelets treatment reveals particle-specific regulation of pathways

Daria Korejwo, Savvina Chortarea, Chrysovalanto Louka, Marija Buljan et autres

Graphene and its derivatives are attractive materials envisaged to enable a wealth of novel applications in many fields including energy, electronics, composite materials or health. A comprehensive understanding of the potential adverse effects of graphene-related materials (GRM) in humans is a prerequisite …

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Airborne emissions from combustion of graphene nanoplatelet/epoxy composites and their cytotoxicity on lung cells via air-liquid interface cell exposure in vitro

Woranan Netkueakul, Savvina Chortarea, Kornphimol Kulthong, Hao Li et autres

Graphene nanoplatelet (GNP) as a nanofiller improves the mechanical strength, electrical conductivity, and flame retardancy of the polymers significantly. With an increasing number of GNP-reinforced products, a careful safety assessment is needed to avoid social and economic setbacks. However, no study has …

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Hazard assessment of abraded thermoplastic composites reinforced with reduced graphene oxide

Savvina Chortarea, Ogul Can Kuru, Woranan Netkueakul, Marco Pelin et autres

Graphene-related materials (GRMs) are subject to intensive investigations and considerable progress has been made in recent years in terms of safety assessment. However, limited information is available concerning the hazard potential of GRM-containing products such as graphene-reinforced composites. In the present study, …

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Hazard Assessment of Abraded Thermoplastic Composites Reinforced with Reduced Graphene Oxide

Savvina Chortarea, Ogul Can Kuru, Woranan Netkueakul, Marco Pelin et autres

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