Tina Buerki‐Thurnherr

An integrated workflow for combined organic and inorganic chemical exposome analysis

Simone Braeuer, Max Lennart Feuerstein, Tina Buerki‐Thurnherr, B. Warth et autres

Humans are exposed to a multitude of non-genetic factors throughout their lives, all of which are encompassed in the concept of the exposome. To assess its chemical component, combinations of complementary analytical techniques are needed for broad chemical space coverage. However, approaches …

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Reconstituting Placenta–Embryo Crosstalk in a Microfluidic Chip for Human‑Relevant Developmental Toxicity Studies

Tina Buerki‐Thurnherr, Manon Murdeu, Isabel Wegner, Xialein Lin et autres

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16 Unravelling the impact of airborne fibres released from natural, bio-based and synthetic textiles on human lung health

Stephanie Eitner, Elias J. Zimmermann, Tina Buerki‐Thurnherr, Bernd Nowack et autres

Abstract Indoor air pollution from airborne micro- and nanoplastics, as well as natural particulate matter, is an emerging health concern. Released textile fibres and debris (eg during washing, drying, wearing) are a significant yet understudied source of this pollution. These fibbers, originating …

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55 Inhalation hazard of graphene-enabled composite materials during manufacture and degradation of market-relevant products

Govind Gupta, Jimmy Vernaz, Antje Vennemann, Maike Stange et autres

Abstract Two-dimensional (2D) graphene-based advanced materials are increasingly utilized across a wide range of applications, including battery technology, superconductors, biomedical products, and catalysis. As their use expands, so does the potential for human exposure, particularly in occupational environments during production, as well …

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Degradation of a graphene-reinforced polyamide by fungi: When culture conditions matter

Lorenzo Fortuna, Fabio Candotto Carniel, Marina Garrido, Alberto Bianco et autres

• Fungi degrade reduced graphene oxide (rGO), polyamide 6 (PA6) and the PA6-rGO complex • Fungal degradation increases in nutrient-depleted media and co-cultures • Hydrolytic by-products of PA6 affect Laccase and Lignin Peroxidase activity • Morel exudates degrade PA6 more efficiently than …

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Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Govind Sharan Gupta, Jonas Bossart, Sènan Mickaël D'Almeida, Luis Augusto Visani de Luna et autres

for 5 weeks) exposure of primary human broncho-epithelial (HBE) cell cultures to hexagonal boron nitride nanosheets (h-BN) and boron nitride nanotubes (BNNTs) increases the phospholipid, sphingolipid, and diglyceride content in cell membranes. Global lipidomics profiling further shows the induction of lipid mediator …

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Shear Stress Modulates PFOS-Induced Cytokine Release and Viability in Placental Explants

Beatrice Anna Brugger, Yvette Hannig, Sarah Zehnder, Peter Wick et autres

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Novel redox 2D nanozymes as promising candidates for the safe treatment of inflammatory diseases during pregnancy

Nikolaos Tagaras, Giacomo Reina, Tina Buerki‐Thurnherr

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Early Life Impact of Diesel Exhaust Particles: Placental Accumulation, Fetal Transfer, and Maternal-Fetal Crosstalk Disruption

Tina Buerki‐Thurnherr

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Medical Materials and Device Innovation: Choosing the Right and Relevant Biological Models

I. F. Herrmann, Tina Buerki‐Thurnherr

Abstract The success of medical devices and biomaterials hinges on selecting biological models that truly reflect human physiology and disease. A well‐chosen model is not just a scientific necessity; it is a clinical imperative. Academic biomedical research often relies on readily accessible …

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OS03-04 Human-based placenta-embryo chip for developmental toxicity assessment of nanoparticles and drugs

Manon Murdeu, Vera Maria Kissling, Paula Navascués, Jacob S. Folz et autres

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Broken but not beaten: Unraveling the biotransformation fate of Mn@PCN224 nanozymes and its influence on enzymatic activity and safety at the human placenta in vitro

Nikolaos Tagaras, Haihan Song, Giacomo Reina, Sandro Lehner et autres

Chronic placental inflammation has been associated with severe pregnancy complications including miscarriage, stillbirth, premature delivery, intra-uterine growth restriction, and recurrence risk in future pregnancies. Treatments are essential, but current standard therapies for infections and inflammation often struggle with limited efficacy and potential …

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